Sclerema neonatorum

Khetarpal, Siddharth K.; Subrahmanyam, V.

doi:10.1007/bf02751673

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…It may be associated with other neonatal comorbidities like sepsis, hypothermia, hypocalcaemia, and congenital anomalies. There may be associated maternal complications like preeclampsia, eclampsia, and prolonged rupture of membranes (PROM), placenta previa, and hyperpyrexia [2, 4–6]. In our case, the affected neonate was preterm associated with sepsis and hypothermia with no obvious congenital anomalies.…”

Section: Discussionmentioning

confidence: 79%

“…Sclerema neonatorum usually affects premature neonates with generalized hardening of skin. It is associated with sepsis and prognosis is usually grave [3–6]. Subcutaneous fat necrosis of newborn (SCFN) usually affects postmature neonates with localized areas of hardness.…”

Section: Discussionmentioning

confidence: 99%

“…Movement, feeding, and respiration are affected due to hardening in such cases. Prognosis is usually poor despite aggressive interventions [3–6]. …”

Section: Introductionmentioning

confidence: 99%

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Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country

Shrestha

Chaudhary

Koirala

2017

Case Reports in Pediatrics

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Sclerema neonatorum is a form of panniculitides characterized by diffuse hardening of subcutaneous tissue with minimal inflammation. It usually affects ill and preterm neonates. Prognosis is usually poor in many cases despite aggressive management. Various treatment modalities (antibiotics, intravenous immunoglobulin, steroids, and exchange transfusion) have been explained in literature. Steroids due to its easy availability and low cost can prove to be lifesaving in such cases, especially in resource poor countries. Here, we report a case of sclerema neonatorum in a one-week preterm baby treated successfully with parenteral steroids and antibiotics.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country

Shrestha

Chaudhary

Koirala

2017

Case Reports in Pediatrics

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“…No definite guidelines are set for the management of SN; some cases have reported the use of systemic corticosteroids which limited the extension of the lesions with no positive effect on overall mortality, 11 , 12 , 13 while others treated a healthy full‐term baby with topical moisturizers without the use of systemic medications. 5 One case report utilised intravenous immunoglobulin in a neonate with SN that subsequently developed septicemia, and although the IVIG did not prevent mortality, it led to a significant improvement in clinical symptoms, warranting further research into the efficacy of such treatment.…”

Section: Discussionmentioning

confidence: 99%

Sclerema neonatorum in a premature newborn: A case report

Alhalabi,

Salloum,

Alhalabi

et al. 2023

Skin Health and Disease

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Sclerema neonatorum (SN) is a rare condition of neonatal panniculitis with a poor prognosis and a high fatality rate. It clinically presents as hardening of the skin and subcutaneous adipose tissue extending throughout the body, sparing the fat‐free soles, palms, and genitalia. SN typically affects gravely ill, preterm neonates in the first week of life and diagnosis is often clinical. We report a case of an eight‐day‐old premature infant diagnosed with early‐onset neonatal sepsis who presented with clinical and histopathological features of SN. Despite early treatment of the sepsis with intravenous antibiotics and the SN with a topical corticosteroid cream and moisturiser, the infant died on the twelfth day of life.

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Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management

Zeb

Darmstadt

2008

J Perinatol

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Objective: To review published literature on sclerema neonatorum (SN) in order to clarify its clinical presentation, histological features and management compared with two other diseases: subcutaneous fat necrosis of the newborn (SCFN) and scleredema.Study Design: PubMed database was searched using the key words Sclerema neonatorum. A total of 55 articles from peer-reviewed journals were reviewed and summarized.Result: SN, SCFN and scleredema are diseases of the subcutaneous adipose tissue. SN is characterized by hardening of the skin that gets bound down to the underlying muscle and bone, hindering respiration and feeding and is associated with congenital anomalies, cyanosis, respiratory illnesses and sepsis. Histology of the skin biopsy shows thickening of the trabeculae supporting the subcutaneous adipose tissue and a sparse inflammatory infiltrate of lymphocytes, histiocytes and multinucleate giant cells. SCFN has circumscribed hardening of skin on bony prominences with necrosis of adipocytes in subcutaneous tissue and a dense granulomatous infiltrate on histology. Scleredema is characterized by hardening of the skin along with edema; histology shows inflammatory infiltrate and edema in skin and subcutaneous tissues. SN has a high case fatality rate whereas SCFN and scleredema are self-limiting and lesions resolve within a few weeks to months. Exchange transfusion may improve survival in SN. Conclusion:The histological features of skin biopsy should be used to establish diagnosis of SN, SCFN and scleredema as disease-specific treatment is imperative in SN due to high fatality.

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Sclerema neonatorum

Cited by 5 publications

References 4 publications

Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country

Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country

Sclerema neonatorum in a premature newborn: A case report

Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management

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