Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark ethanolic extract (SBE) modulates blood glucose, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) of STZ-induced diabetic rats

Gondwe, Mavuto; Kamadyaapa, David R; Tufts, Mark; Chuturgoon, Anil A.; Musabayane, C T

doi:10.1016/j.phymed.2008.02.004

Cited by 51 publications

(49 citation statements)

References 29 publications

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“…We and several other authors have previously used Ccr in rats as a fundamental parameter of evaluating renal tubular function to monitor GFR. [15,16,[24][25][26] Low GFR is associated with fluid and electrolyte imbalance in nephrotic syndrome [27] and acute renal failure. [28][29][30] It is therefore speculated that OA administration significantly improved renal function of STZ-induced diabetic rats, perhaps in part mediated via the elevation of GFR.…”

Section: Discussionmentioning

confidence: 99%

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

et al. 2009

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Previous studies from our laboratories indicate that the antidiabetic effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (3ß-hydroxy-olea-12-en-28-oic acid, OA) and ursolic acid (3ß -hydroxyl-urs-12-en-28-oic acid, UA). For the bioactive compounds to have potential in diabetes management, they should alleviate or prevent complications of diabetes mellitus, kidney function, and cardiovascular disorders. This study was, therefore, designed to assess whether S. cordatum leaf derived OA influenced renal function evaluated by the ability to increase urinary Na + outputs parameters and creatinine clearance (Ccr) of streptozotocin (STZ)-induced diabetic rats. Extraction and fractionation of S. cordatum powdered leaf ethyl acetate-solubles (EAS) yielded mixtures of OA/UA and methyl maslinate/methyl corosolate. Recrystallization of OA/UA mixture using ethanol afforded OA, the structure of which was confirmed by NMR spectroscopy ( 1 H & 13 C). Acute effects of OA on kidney function and mean arterial blood pressure (MAP) were investigated in anesthetized rats challenged with hypotonic saline after a 3.5-h equilibration for 4h of 1 h control, 1.5 h treatment, and 1.5 h recovery periods. OA was added to the infusate during the treatment period. Chronic effects of OA were studied in individually caged rats treated twice daily with OA (60 mg/kg, p.o.) for five weeks. By comparison with respective control animals administration, OA significantly increased Na + excretion rates of non-diabetic and STZ-induced diabetic rats without affecting urine flow, K + and Cl − rates. At the end of five weeks, OA treatment significantly (p < 0.05) increased Ccr in non-diabetic (2.88 ± 0.14 vs. 3.71 ± 0.30 ml/min) and STZdiabetic rats (1.81 ± 0.32 vs. 3.07 ± 0.16 ml/min) with concomitant reduction of plasma creatinine concentration (n = 6 in all groups). OA also caused significant decreases in MAP in nondiabetic and STZ-induced diabetic rats. These findings suggest that OA may have beneficial effects on some processes associated with renal derangement of STZ-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

et al. 2009

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“…Numerous in vitro and in vivo studies to con�rm biological activity include antidiarrheal, anti-in�ammatory, antimalarial, antimicrobial, antiplasmodial, antihypertensive, anticonvulsant, antinociceptive, and antioxidant investigations which have been undertaken to verify traditional use of various plant parts [136][137][138][139]. It is suggested that S. Birrea stem bark extracts exert reno-and cardio-protective effects in diabetes mellitus [140]. Bark and leaf ethanolic extracts tested for antimicrobial activity ranged from 0.15 to 3 mg/mL [136].…”

Section: Phytochemistry and Biologicalmentioning

confidence: 99%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

145

114

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ere is a growing interest in natural plant-based remedies as a source for commercial products. Around 80% of the South African population use traditional medicines to meet their primary health care needs; however, only a few South African medicinal plants have been exploited to their full potential in terms of commercialization. e opportunity for bioprospecting of plant compounds for novel pharmaceuticals remains largely untapped. Certain renowned medicinal plants of international acclaim including buchu and rooibos are currently contributing to local enterprise; however, other exciting opportunities exist for commonly used plants which have not yet reached the international arena. is paper focuses on the key research and development contributions of 10 commercially important medicinal plants of South Africa. �raditional uses, scienti�c validation, commercialisation developments, as well as both potential opportunities and setbacks are discussed.

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“…43,44 We have, however, reported that extracts of Persea americana Mill (Lauraceae) ("Avocado") decrease the viability of kidney cell lines in vitro. 45 Furthermore, aristolochic acid isolated from Aristolochia fangchi was shown to induce cellular injury and apoptosis in proximal tubular (LLC-PK1) epithelial cell lines. [46][47][48][49] The results described in this study introduce the first in vivo evidence that the previously reported OA-evoked increases in urinary Na þ output are in part mediated via inhibition of Na þ reabsorption and increases in proximal tubular Na þ secretion.…”

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confidence: 99%

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

et al. 2012

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Studies indicate that Syzygium spp-derived oleanolic acid (OA) enhances renal function of streptozotocin (STZ)-induced diabetic rats as evidenced by its reversal of the previously reported inability of the kidney to excrete Na þ in these animals. We postulated that OA influences Na þ excretion in the proximal tubule, the site where two-thirds of filtered NaCl is reabsorbed through a process mediated by transport proteins. Therefore, the study investigated the effects of OA on proximal tubular Na þ handling in male Sprague-Dawley rats using renal lithium clearance (C Li ). Renal C Li has been used widely in animal and clinical studies to assess proximal tubular function. Sub-chronic doses of OA were administered to rats twice every third day for 5 weeks. Rats treated with deionized water served as control animals. Cytotoxicity of OA on kidney and liver cell lines was assessed by the MTT and comet assays. OA increased Na þ excretion of conscious male Sprague-Dawley rats from week 3 to week 5. By the end of the 5-week experimental period, OA treatment significantly reduced (p < 0.05) plasma creatinine concentration of STZ-induced diabetic rats with a concomitant elevation in glomerular filtration rate (GFR). Acute OA infusion was also associated with increases in fractional excretion of sodium (FE Na ) and lithium (FE Li ) in anesthetized rats in the absence of significant changes in GFR. The MTT assay studies demonstrated that OA increased the metabolic activity of kidney and liver cell lines. Taken together with previous observations, this study implicates the proximal tubule in OA-evoked increases in urinary Na þ output.

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Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark ethanolic extract (SBE) modulates blood glucose, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) of STZ-induced diabetic rats

Cited by 51 publications

References 29 publications

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

Renal Effects of Plant-Derived Oleanolic Acid in Streptozotocin-Induced Diabetic Rats

Commercially Important Medicinal Plants of South Africa: A Review

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

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