Sclerodcrmatous skin reaction after vitamin K₁ injections

Update on morphea

“…There are also reports of morphea lesions occurring after vitamin B 12 and vitamin K injections (Texier disease). [29][30][31][32] The trauma of the injection may induce an overexuberant healing process that results in unchecked fibrosis.…”

Nicolau syndrome induced by intramuscular vitamin K in a premature newborn

“…There are three distinct types of cutaneous reactions to vitamin K1: localized eczematous, localized morphea-form and, very rarely, diffused maculopapular eruption [6]. Hypersensitivity and immunologic mechanisms are believed to have a pathogenetic role in the eczematous and sclerodermoid types of lesions [3]. However, our patient was a premature newborn, and immaturity of the immune system in our patient does not support this hypothesis.…”

Drug-induced morphea: Report of a case induced by balicatib and review of the literature

“…3,16 Finally, vitamin K 1 and vitamin B 12 may induce morphea-like lesions locally, possibly in relation to a toxic effect of the vehicle (oilsoluble preparation) or the preservative (benzyl alcohol), or to a hypersensitivity reaction. [17][18][19] We report herein the appearance of morphea-like lesions after therapy with a cathepsin K inhibitor. Cathepsin K belongs to a group of cysteine proteases that were long believed to be primarily involved in intracellular protein turnover, but now known to also be active in the extracellular environment.…”

“…Vitamin Ke, vitamin B 12 e, and pentazocine-induced morphea was always limited at site of injection. [16][17][18][19][20] Morphology of lesions was that of typical plaque morphea. In two cases bullous lesions were present.…”