Scleroderma, Amyloidosis, and Extensor Tendon Rupture

Horwitz, Harold M.; Dibeneditto, Joseph D.; Allegra, Salvatore R.; Baumann, Harvey M.

doi:10.1002/art.1780250919

Cited by 16 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We noticed rupture of both hand extensor tendons of the fourth and fifth fingers in this patient. Similarly, tendon rupture was reported in the fourth and fifth fingers in previous case reports [ 10 , 11 ]. Here, we supposed that extensor tendon rupture mostly appeared in the fourth and fifth fingers because of the local anatomical structure.…”

Section: Discussionsupporting

confidence: 74%

Spontaneous tendon rupture in a patient with systemic sclerosis: a case report

Liu

Shen

Jiang

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Systemic sclerosis (SSc) is an incurable autoimmune disease characterized by progressive skin fibrosis and organ failure. Tenosynovitis is a common musculoskeletal manifestation, but tendon rupture has seldom reported in SSc. Case presentation We present a rare case of a 49-year-old female with SSc who has suffered from bilateral tendon rupture of the fourth and fifth digits with positive antinuclear antibody (ANA) and anti-centromere B antibody, but negative rheumatoid factor in serum. In the extensor tendons of the patient’s hands, inflammation, edema, hypertrophy and tendon interruption were detected with ultrasound and magnetic resonance imaging(MRI). Tendon transfer repair surgery was performed and 10 mg/week methotrexate was then used in this patient. Her hand function was improved well with methotrexate and rehabilitation treatment postoperatively. Conclusions Early detection of tenosynovitis is necessary to prevent tendon rupture in SSc patients. Ultrasound and Magnetic Resonance Imaging appear to be useful examinations for evaluating tendon pathology for early detection.

show abstract

Section: Discussionsupporting

confidence: 74%

Spontaneous tendon rupture in a patient with systemic sclerosis: a case report

Liu

Shen

Jiang

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…Attenuation o r rupture of tendons in PSS alone has >not been reported previously, which is in contrast with the relatively frequent rupture of the extensor tendons of the thumb and fingers in RA (1) and the occasional occurrence of such tendon ruptures in SLE (5). Individual tendon rupture, rather than rupture of the (entire tendon mechanism, is the rule in RA.…”

Section: Arthritis and Rheumatism Val 28 No 5 (May 1985)mentioning

confidence: 85%

“…It is possible that our patient's therapy may have played a role in the development of this complication. It has been suggested that corticosteroids contribute t o tendon rupture in RA and SLE (5,6). These compounds are presumed t o impair tendon healing through their catabolic effects and the induction of a negative nitrogen balance.…”

Section: Arthritis and Rheumatism Val 28 No 5 (May 1985)mentioning

confidence: 99%

Wrist drop in progressive systemic sclerosis (scleroderma): complete rupture of the extensor tendon mechanism

Rosenbaum

Swartz

Rodnan

et al. 1985

Arthritis & Rheumatism

View full text Add to dashboard Cite

“…SAA is an acute phase protein that contributes to deposition of amyloid in tissues; however, only a few studies have reported amyloidosis A in patients with SSc. [9][10][11][12] SAA may also play a role in the pathogenesis of autoimmune diseases, atherosclerosis, and tumors. 13…”

Section: Introductionmentioning

confidence: 99%

High acute phase protein levels correlate with pulmonary and skin involvement in patients with diffuse systemic sclerosis

et al. 2018

View full text Add to dashboard Cite

ObjectiveThis study was performed to evaluate the serum amyloid A (SAA) and C-reactive protein (CRP) levels in patients with diffuse systemic sclerosis (dSSc) in relation to a control group, disease duration, and skin and pulmonary involvement.MethodsThis case-control study included 18 patients with early dSSc, 15 patients with late dSSc, and 15 healthy controls. The SAA and CRP levels, modified Rodnan skin score (mRSS), and diffusing capacity of the lungs for carbon monoxide (DLCO) were determined in all patients.ResultsThe SAA and CRP levels were significantly higher in patients with early and late dSSc than in healthy controls. The frequency of detection of elevated SAA and CRP levels was approximately 66% and 85%, respectively. A significant correlation was found between the SAA and CRP levels in patients with dSSc. The SAA and CRP levels were inversely correlated with DLCO. The CRP level was positively correlated with the mRSS.ConclusionsHigh SAA and CRP levels could serve as biomarkers for pulmonary involvement. The serum CRP level accurately reflects the extension of skin thickening in patients with dSSc.

show abstract

Scleroderma, Amyloidosis, and Extensor Tendon Rupture

Cited by 16 publications

References 2 publications

Spontaneous tendon rupture in a patient with systemic sclerosis: a case report

Spontaneous tendon rupture in a patient with systemic sclerosis: a case report

Wrist drop in progressive systemic sclerosis (scleroderma): complete rupture of the extensor tendon mechanism

High acute phase protein levels correlate with pulmonary and skin involvement in patients with diffuse systemic sclerosis

Contact Info

Product

Resources

About