Scleroderma and Calcinosis

Durham, Robert H.

doi:10.1001/archinte.1928.00130210015002

Cited by 50 publications

(5 citation statements)

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“…The close association between soft-tissue calcification and conditions such as scleroderma (Thibierge and Weissenbach, I9I1) and Raynaud's disease (Logan, I924; Langmead, I930; Durham, 1928) has been observed for many years, but doubt has recently been cast on the association between calcinosis and Raynaud's disease by Cole (Cole, 1953), who considers, after a close study of the reported cases, that this, in fact, represents a developing scleroderma. Attention has been recently focused again on the question of soft-tissue calcification and its relation to the collagen diseases in a thoughtprovoking paper by Clayton E. Wheeler and his colleagues (Wheeler et al, 1952).…”

Section: Calcinosis Circumscriptamentioning

confidence: 99%

Calcinosis

Kilburn

1957

Postgraduate Medical Journal

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Section: Calcinosis Circumscriptamentioning

confidence: 99%

Calcinosis

Kilburn

1957

Postgraduate Medical Journal

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“…Present consideration is directed toward this last feature, of which Raynaud's phenomenon is usually an integral part. As in our patient, acrosclerosis and calcinosis may coexist, thus constituting the Thibierge-Weissenbach syndrome (9)(10)(11)(12)(13). This dystrophic calcification is common to many of the collagenous disorders and to some cases of Raynaud's disease (14).…”

mentioning

confidence: 53%

Angiopathies in Acrosclerosis

1955

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The clinical distinction between acrosclerosis and diffuse progressive scleroderma, although arbitrary, is nevertheless convenient. Acrosclerosis is almost invariably accompanied, and usually preceded, by the Raynaud phenomenon and occurs typically in adult women as a slowly progressive disorder. Although sclerodactylia, with vasomotor, trophic, and even ulcerative peripheral changes, predominates, other varying accompaniments include facial sclerosis, dysphagia, and widespread visceral involvement. In the following illustrative case with calcinosis (Thibierge-Weissenbach syndrome) there was also occlusion of certain large-caliber arteries, a feature which has not previously received clinical study.REPORT OF CASE H. C. H., a housewife aged 53, had been admitted with severe ulceration of both legs to this hospital on three occasions since 1950. This began in 1941 and was followed by repeated breaking down and healing. The third admission on September 16, 1953 was necessitated by gangrene of the right little toe. She had been very fit until the age of 20, when there occurred repeated eruptions of chilblains and vague paresthesiae in the fingers. About 10 years later, stiffness occurred in the fingers and toes, and odd telangiectases were then first observed and were later distributed over the face, lips, tongue, neck, and dorsa of the hands. Six years before the third admission, calcareous material was extruded from the front of the right knee, and two years later several hard pea-sized nodules appeared on the outer surface of the right forearm. There had been no pregnancies, and the menopause occurred at age 40. There was no dysphagia.Physical examination revealed good physique. The face ( fig. 1) had a faint patchy, coppery pigmentation and was studded with port wine-colored telangiectases, and the normal creases were obliterated. The tongue showed a small angioma in the middle of its right border ( fig. 1). The hands had advanced sclerodactylia, and on the back of the right forearm there was a group of five gritty, pea-sized subcutaneous nodules (fig. 2). The right foot was extensively ulcerated on the dorsum, thus exposing the extensor tendons ( fig. 3), and an ulcer two inches in diameter covered the internal malleolus. Gangrene of the little toe and incipient gangrene of the fourth toe were also present. On the inner aspect of the left ankle there were several shallow healing ulcers.In the right leg, no pulsation could be felt below the femoral artery in Scarpa's triangle. In the left leg, normal pulsation was felt in all the large arteries except the posterior tibial. The rest of the cardiovascular system revealed no abnormality except an apical systolic murmur and hypertension (170/100). The other systems showed no abnormalities.

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“…In 1928 Durham [8] found th at the blood calcium and phosphorus Kl-Hefnatvi, Calcinosis Cutis Circumscripta of the Scrotal Wail levels are generally normal. In the m ajority of reported cases, the blood calcium and phosphorus have been normal, though high cal cium values have been at times recorded by Brooks [9] in 1934.…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Cutis Circumscripta of the Scrotal Wall

El-Hefnawi¹

1963

Dermatology

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Scleroderma and Calcinosis

Cited by 50 publications

References 25 publications

Calcinosis

Calcinosis

Angiopathies in Acrosclerosis

Calcinosis Cutis Circumscripta of the Scrotal Wall

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