Scleroderma and scleroderma-like disorders

Rocco, Vito K.; Hurd, Eric R.

doi:10.1016/0049-0172(86)90040-5

Cited by 57 publications

(13 citation statements)

References 286 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Progressive systemic sclerosis (SSc) or diffuse scleroderma is a connective tissue disease of unknown etiology, characterized by vascular abnormalities, multiorgan fibrosis and complex immune system alterations (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

et al. 2007

View full text Add to dashboard Cite

Objective: Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up. Design: The aim of our study was to evaluate the prevalence of thyroid disorders in a large number of patients with SSc using a complete clinical evaluation. Methods: Thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, antithyroglobulin and antithyroid-peroxidase (AbTPO) autoantibodies, thyroid ultrasonography and blood flow and fine needle aspiration were performed in 202 SSc patients versus 404 gender-and age-matched controls from the general population, with similar iodine intake, to evaluate the prevalence of clinical and subclinical thyroid disorders. Results: Odds ratio (OR) for female SSc versus controls was: for subclinical hypothyroidism, 3.2 (95% CI)Z1.8-5.7); for clinical hypothyroidism, 14.5 (95% CIZ2.3-90.9); for AbTPO positivity, 2.7 (95% CIZ1.8-4.1); for hypoechoic pattern, 3.2 (95% CIZ2.2-4.7); for thyroid autoimmunity, 3.7 (95% CIZ2.6-5.4); for thyroid volume !6 ml, 1.8 (95% CIZ1.2-2.7). OR for thyroid autoimmunity in male SSc versus controls was 10.8 (95% CIZ2.2-52.4). Mean values of TSH in female SSc, and of AbTPO in female and male SSc were higher (P!0.01) than in controls. We observed three cases of Graves' disease in female SSc versus zero in controls (PZ0.0140), and two cases of papillary thyroid cancer in SSc patients. Conclusions: Thyroid function, AbTPO and ultrasonography should be tested as part of the clinical profile in SSc patients. Females, subjects with positive AbTPO and hypoechoic and small thyroid should have thyroid function follow-up and appropriate treatment in due course.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Systemic sclerosis (SSc; scleroderma) is a connective tissue disease characterized by skin thickening and internal organ involvement (1)(2)(3)(4)(5). There is great heterogeneity in the clinical presentation, progression, and severity of SSc.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of SSc in the United States is estimated to be approximately 300,000, with incidence rates estimated at [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] per million per year (1)(2)(3)(4)(5). Incidence is believed to have increased over the past 3 decades (2).…”

Section: Introductionmentioning

confidence: 99%

Psychological adjustment to systemic sclerosis

Malcarne

Greenbergs

1996

Arthritis & Rheumatism

View full text Add to dashboard Cite

“…Embora a constatação do fenômeno de Raynaud seja achado comum a todas as colagenoses, sua presença sugere o diagnóstico de esclerodermia, a qual ocorre em até 95% dos casos. 12 No lúpus sistêmi-co, a literatura registra prevalência entre 18 e 45%. 1 Por último, é necessário observar que, nessa população, a idade ao diagnóstico não influiu no aparecimento de nenhuma das lesões cutâneas observadas.…”

Section: Discussionunclassified

Envolvimento mucocutâneo no lúpus eritematoso sistêmico e sua associação com auto-anticorpos

Machado

Dykyj

Vandresen

et al. 2008

An. Bras. Dermatol.

View full text Add to dashboard Cite

Resumo: FUNDAMENTOS -As manifestações mucocutâneas são comuns em pacientes com lúpus eritematoso sistêmico, podendo assumir espectro bastante variado. OBJETIVOS -Estudar a prevalência de lesões mucocutâneas no lúpus eritematoso sistêmico e verificar suas possíveis associações com auto-anticorpos. MÉTODOS -Submeteram-se 113 pacientes com lúpus eritematoso sistêmico a anamnese dirigida para envolvimento mucocutâneo e exame ectoscópico. Seus prontuários foram examinados para dados demográficos e perfil de auto-anticorpos como anti-Ro/SS-A, antiLa/SS-B, antiDNA e anti-Sm. RESULTADOS -Os achados mais prevalentes foram os de fotossensibilidade (83,1%), alopecia (65,4%), eritema em vespertílio (54,3%) e fenômeno de Raynaud (53,9%). Em 46,9% existia algum tipo de queixa mucocutânea no momento do diagnóstico da doença. Encontrou-se associação entre a ocorrência de lúpus cutâneo subagudo e presença do anti-Ro/SS-A (p = 0,03), do fenômeno de Raynaud e o anticorpo anti-Sm (p = 0,05) e do eritema em vespertílio e o anticorpo antiDNA (p = 0,03). CONCLUSÃO -Os achados mucocutâneos estão presentes na maioria dos pacientes com lúpus sistêmico, existindo em aproximadamente metade deles no momento do diagnóstico. As lesões mais comuns foram fotossensibilidade, alopecia, eritema em vespertílio e fenômeno de Raynaud. Palavras-chave: Anticorpos antinucleares; Dermatopatias; Lúpus eritematoso cutâneo; Lúpus eritematoso sistêmico; Membrana mucosa (anti-Ro/SS-A, anti-La/SS-B, anti-DNA and anti-Sm). RESULTS -The most prevalent findings were photosensitivity (83.1%), alopecia (65.4%), butterfly rash (54.3%) and Raynaud's phenomenon (53.9%) Abstract: BACKGROUND -Mucocutaneous manifestations are very common in systemic lupus erythematosus and vary widely. OBJECTIVES -To study the prevalence of mucocutaneous lesions in systemic lupus erythematosus and to verify their possible association with autoantibodies. METHODS -One hundred and thirteen patients with systemic lupus erythematosus underwent clinical history directed to skin disorders and ectoscopic examination. Their charts were reviewed for demographic data and autoantibody profile

show abstract

Scleroderma and scleroderma-like disorders

Cited by 57 publications

References 286 publications

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

Psychological adjustment to systemic sclerosis

Envolvimento mucocutâneo no lúpus eritematoso sistêmico e sua associação com auto-anticorpos

Contact Info

Product

Resources

About