Scleroderma-like cutaneous lesions induced by paclitaxel: A case study

Kupfer, I.; Balguérie, X.; Courville, Philippe; Chinet, P.; Joly, P.

doi:10.1067/mjd.2003.30

Cited by 72 publications

(57 citation statements)

References 10 publications

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“…This recurred after paclitaxel rechallenge and subsequently evolved into cutaneous sclerosis. 186 Subacute cutaneous lupus erythematosus has also been identified in one patient. 170 Paclitaxel has also been shown to induce erythema, tenderness, and discomfort along the course of an injected vein and inflammation in areas of drug extravasation.…”

Section: Taxanesmentioning

confidence: 96%

Chemotherapeutic agents and the skin: An update

Heidary

Naik

Burgin

2008

Journal of the American Academy of Dermatology

224

138

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Section: Taxanesmentioning

confidence: 96%

Chemotherapeutic agents and the skin: An update

Heidary

Naik

Burgin

2008

Journal of the American Academy of Dermatology

224

138

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“…5 Other texts are reports or series of cases focusing only on a facet of cuta neous adver se reac tions, such as a "photo recall" phe no me non, gene ra li zed pus tu lar der ma to sis, scle ro derm-like reac tions, fixed pig men ted ery the ma and eryth rody ses the sia, 3,6,7,8,9 Acral or pal mar-plan tar eryth rody ses the sia (PPE) is a pecu liar cuta neous and neu ro lo gi cal symptom com plex asso cia ted with the use of TX, mainly DC. It has already been found in patients that made use of PC or other che mo the ra peu tic agents (cyta ra bine, doxo ru bi cin and 5-fluo rou ra cil).…”

Section: Discussionmentioning

confidence: 99%

Efeitos colaterais cutâneos de quimioterapia com taxanos: O ponto de vista do dermatologista

Donati

Castro

2011

An. Bras. Dermatol.

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Abstract:Chemotherapy with taxanes has recently become part of the treatment for many advanced neoplastic diseases, specially breast and lung cancer. Their main noncutaneous adverse reactions include neutropenia and mucositis, which eventually lead to drug discontinuation. Cutaneous adverse reactions are frequent and significantly interfere with the patient's quality of life. Treatments are poorly effective, but special recommendations may improve symptoms and prevent relapses requiring drug rechallenge. Keywords: Drug Eruptions; Drug Therapy; Cutaneous adverse reactions; Paclitaxel; Taxoids Resumo: Taxanos são drogas quimioterápicas cada vez mais utilizadas no tratamento adjuvante de um grande número de cânceres, principalmente câncer de mama e de pulmão. Os efeitos colaterais não cutâ-neos mais importantes e limitantes do uso destas drogas são neutropenia e mucosite. Os efeitos colaterais cutäneos, além de muito frequente, interfere de forma importante na qualidade de vida dos doentes. Não existem tratamentos totalmente eficazes, mas algumas orientações podem diminuir os sintomas e prevenir recidivas em novas sessões de quimioterapia. Palavras-chave: Erupção por droga; Paclitaxel; Quimioterapia; Taxóides; Toxicidade de drogas ©2011 by Anais Brasileiros de Dermatologia CASE REPORT INTRO DUC TIONTaxanes (TX) are drugs used to treat seve ral types of neo pla sias, such as breast and lung can cer. There are 2 types of TX in Brazil: pacli ta xel (PC) (Taxol ® ) and doce ta xel (DC) ( Taxotere ® ). The most com mon side effects of these drugs are neu tro pe nia and muco si tis. They pre sent a simi lar mode of action but a dis tinct pro fi le regar ding cuta neous adver se reac tions.1 With the pur po se of making der ma to lo gists more fami liar with this kind of reac tion, which will beco me more fre quent with grea ter uti li za tion of TX, we report below 4 cases that were fol lo wed in a derma to logy offi ce. CASE REPORT1 -Female patient, 54 years old, after 4 years of breast can cer treat ment with mas tec tomy and che mothe rapy (CTH) with other drugs, pre sen ted bone and liver metas ta ses; a new CTH series was star ted with PC and car bo pla tin. Two months later she pre sen ted erythe ma and hyperch ro mia on the back of hands and on the face, accom pa nied by dyses the sia with local burning sen sa tion (Figure 1). She wore a mois tu ri zer and pho to pro tec tor, and was orien ted to avoid sun exposu re. Two months later, in view of the inten sity of cuta neous adver se reac tions, PC was repla ced by DC, with great impro ve ment of symptoms. After 2 cycles of the new drug, she deve lo ped phle bi tis at the place of infu sion with linear hyper pig men ta tion fol lo wing the venous path way (Figure 2). The ele men tary lesions of this second epi so de were simi lar to those obser ved in the first. She was trea ted with creams com po sed of tre ti noin/hydro qui no ne/fluo ci no lo ne on the face and

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“…En effet, des cas de carcinome é pidermoïde ont é té dé crits chez des patients ayant une morphé e gé né ralisé e. Cette association ne semble pas ê tre fortuite é tant donné la rareté des morphé es gé né ralisé es et l'utilisation fré quente de la Puvathé rapie dans le traitement de ces sclé rodermies [14,16,17] ; -on peut observer une association entre morphé e et certains cancers, particuliè rement les cancers colorectaux [6,8], tel est le cas de notre observation, le cancer du sein [9] et les syndromes carcinoïdes [1] ; -la morphé e peut survenir dans des zones qui sont irradié es chez des patients ayant dé jà un cancer, notamment du sein [2] ; -quelques cas de morphé e induite par des traitements chimiothé rapiques pour un cancer ont é té dé crits [7] ; -enfin, aspect sclé rodermiforme que peuvent prendre des mé tastases cutané es de certains cancers, notamment le cancer de la prostate [13].…”

Section: Commentairesunclassified

Morphée généralisée révélatrice d’un adénocarcinome rectal

et al. 2008

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The term Scleroderma unites a heterogeneous group of disease of conjunctive tissue with, unknown in etiology and wich have together an induration of the skin. The association of the scleroderma and neoplasy were not clearly reported. We report an observation of association between a generalised morphea and a rectal cancer. Ms D.B., aged of 62 years old, with no pathologic antecedents, was hospitalised in 2005 for multiple plaques, white, indurated, and localised in the trunk and the lower extremities. The lesions have evolved for one month and a half. The diagnosis of generalised morphea was suspected. The cutaneous biopsy concluded a scleroderma. The antinuclear antibody (anti-Scl 70) was negative. The patient was treated by prednisone (0,75 mg/kg/day) with a slight amelioration. During his hospitalisation, the patient suffered from constipation and the questionnaire showed a sensation of intrarectal body since 3 months. The rectoscopy revealed a big rectal tumor. The rectal biopsy concluded to differentiated luberkinien adenocarcinoma. This rectal tumor was treated by a radiotherapy associated with chemotherapy then followed by surgery. The morphea worsened 2 months later. The association between the generalised morphea and the cancer is rare. There is many arguments to paraneoplasic character of generalised morphea.

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Scleroderma-like cutaneous lesions induced by paclitaxel: A case study

Cited by 72 publications

References 10 publications

Chemotherapeutic agents and the skin: An update

Chemotherapeutic agents and the skin: An update

Efeitos colaterais cutâneos de quimioterapia com taxanos: O ponto de vista do dermatologista

Morphée généralisée révélatrice d’un adénocarcinome rectal

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