Scleroderma-like nailfold capillaroscopic abnormalities are associated with                 anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Furtado, Rita Nely Vilar; Pucinelli, Mário Luiz Cardoso; Cristo, Valéria Valim; Andrade, Luís Eduardo Coelho; Sato, Emília Inoue

doi:10.1191/0961203302lu144oa

Cited by 89 publications

(71 citation statements)

References 26 publications

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“…In a study with children and adults, the SLEDAI and presence of anti-RNP antibodies were associated with changes on NFC. 25 In our study the four patients positive for anti-RNP showed no changes on NFC.…”

Section: Discussionsupporting

confidence: 41%

Capilaroscopia periungueal em crianças e adolescentes com doenças reumáticas

Piotto¹,

Len²,

Hilário³

et al. 2012

Rev. Bras. Reumatol.

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Objective: To assess nailfold capillaroscopy in children and adolescents with autoimmune rheumatic diseases (juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, scleroderma and mixed connective tissue disease) and relate it to clinical and laboratory fi ndings and disease activity. Methods: Cross-sectional study assessing 147 patients by use of nailfold capillaroscopy as follows: 60 with juvenile idiopathic arthritis; 30 with systemic lupus erythematosus; 30 with juvenile dermatomyositis; 20 with localized scleroderma; four with systemic sclerosis; and three with mixed connective tissue disease. Clinical and laboratory tests and nailfold capillaroscopy were performed in all patients. The nailfold capillaroscopy was performed with an optical microscope (at 10-and 16-time magnifi cations) by the same observer. Results: Most patients (76.2%) had normal nailfold capillaroscopy. The major changes in nailfold capillaroscopy, characterizing the scleroderma pattern, were observed in patients with juvenile dermatomyositis, systemic scleroderma and mixed connective tissue disease. There was no association between nailfold capillaroscopy and disease activity in patients with juvenile idiopathic arthritis, systemic lupus erythematosus and localized scleroderma. Disease activity and capillaroscopy were associated in patients with juvenile dermatomyositis. Conclusion: Nailfold capillaroscopy is a useful method to diagnose autoimmune rheumatic diseases and monitor disease activity.

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Section: Discussionsupporting

confidence: 41%

Capilaroscopia periungueal em crianças e adolescentes com doenças reumáticas

Piotto¹,

Len²,

Hilário³

et al. 2012

Rev. Bras. Reumatol.

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“…It is better detected by capillaroscopy. Nailfold telangiectasias in SLE patients were associated with anti-U1RNP antibodies [77]. In addition, telangiectasias and erythema of the nailfold were found in 76% of patients who hadboth DLE and SLE, but none in patients with DLE in the absence of SLE, suggesting that this is a rather sensitive indicator for systemic disease activity [78].…”

Section: Periungual Telangiectasiasmentioning

confidence: 99%

Cutaneous manifestations of systemic lupus erythematosus

2018

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Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient.

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“…It is not unusual, for example, that a patient with SLE presents isolated features suggestive of systemic sclerosis, such as swollen fingers, Raynaud's phenomenon, and esophageal dismotility (Furtado et al 2002). In some cases, there is concomitant full-blown presentation of two or more of these conditions.…”

Section: Table Imentioning

confidence: 99%

Future perspective for diagnosis in autoimmune diseases

Andrade

2009

An. Acad. Bras. Ciênc.

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Human beings have taken successive approaches for the understanding and management of diseases. Initially brewed in supernatural concepts and mystical procedures, a vigorous scientific approach has emerged on the grounds of fundamental disciplines such as anatomy, microbiology, biochemistry, physiology, immunology, pathology, and pharmacology. The resulting integrated knowledge contributed to the current classification of diseases and the way Medicine is carried out today. Despite considerable progress, this approach is rather insufficient when it comes to systemic inflammatory conditions, such as systemic lupus erythematosus, that covers clinical conditions ranging from mild pauci-symptomatic diseases to rapidly fatal conditions. The treatment for such conditions is often insufficient and novel approaches are needed for further progress in these areas of Medicine. A recent breakthrough has been achieved with respect to chronic auto-inflammatory syndromes, in which molecular dissection of underlying gene defects has provided directions for target-oriented therapy. Such approach may be amenable to application in systemic auto-immune diseases with the comprehension that such conditions may be the consequence of interaction of specific environmental stimuli and an array of several and interconnected gene polymorphisms. On the bulk of this transformation, the application of principles of pharmacogenetics may lead the way towards a progressively stronger personalized Medicine.Key words: autoimmunity, pharmacogenetics, gene polymorphism, auto-inflammatory diseases, systemic lupus erythematosus, rheumatoid arthritis. HISTORICAL PERSPECTIVE IN DIAGNOSIS PARADIGMSince ancient times, human beings have struggled to provide help to those suffering from the diverse illnesses that affect mankind and other living beings. Primitive paradigms were mainly based on instinct, mysticism and supernatural approaches. Dance rituals and magic medicines were the answer that those early professionals provided to the sufferers. With the advent of the early founders of the contemporary medical science in the Mediterranean area, a rational, observational and ethical approach was progressively established. Accordingly, the diagnostic and therapeutic approaches wereIn commemoration of the 75 th anniversary

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Scleroderma-like nailfold capillaroscopic abnormalities are associated with anti-U1-RNP antibodies and Raynaud's phenomenon in SLE patients

Cited by 89 publications

References 26 publications

Capilaroscopia periungueal em crianças e adolescentes com doenças reumáticas

Capilaroscopia periungueal em crianças e adolescentes com doenças reumáticas

Cutaneous manifestations of systemic lupus erythematosus

Future perspective for diagnosis in autoimmune diseases

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