Scleroderma-like skin changes not involving the hand in a prepubertal male with type I diabetes mellitus

Pitukcheewanont, Pisit; Bali, Bhavna; Somanunt, Sinjira; Reiff, Andreas

doi:10.4161/derm.3.4.14614

Cited by 3 publications

(1 citation statement)

References 5 publications

(9 reference statements)

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discuss the possible mechanisms by which vitamin D may have a therapeutic role in managing a variety of infections.In the second article Pisit Pitukcheewanont et al 2 take a look at the interaction of skin and pancreas. They report an interesting case with Scleroderma-like skin changes (early morphea-type skin changes of the trunk and extremities) not involving the hand in a prepubertal male with type I diabetes mellitus.

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mentioning

confidence: 99%

Hormones and skin: A never ending love story!

Reichrath¹

2011

Dermato-Endocrinology

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discuss the possible mechanisms by which vitamin D may have a therapeutic role in managing a variety of infections.In the second article Pisit Pitukcheewanont et al. 2 take a look at the interaction of skin and pancreas. They report an interesting case with Scleroderma-like skin changes (early morphea-type skin changes of the trunk and extremities) not involving the hand in a prepubertal male with type I diabetes mellitus. The authors explain that, to their knowledge there have been no reports of sclerodermalike skin changes, not affecting the hand in prepubertal patients with type I diabetes mellitus.In the following paper, Shwetha Thukuntla and Pratima Kumar 3 report on the effects of androgens on the skin. They present an interesting case with improvement of venous leg ulcers with androgen replacement therapy in a patient with undiagnosed Klinefelter syndrome.In the fourth article, Fatme Al Anouti et al. 4 demonstrate and discuss their surprising findings on vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates. They convincingly show that vitamin D deficiency could be a major public health burden among young Emirati adults, mostly because of sun deprivation in a sun-blessed country. Their study included a random sample of 138 females and 70 males tested for serum 25-hydroxyvitamin D [25(OH)D] status. To further evaluate the predictors of vitamin D status in this population, the authors examined diet, obesity and sun exposure. In summer, the mean serum 25(OH)D concentration for females was 20.9 ± 14.9 nmol/L, whereas that for males was 27.3 ± 15.7 nmol/L. Females scored significantly higher than males on the sun avoidance inventory (SAI), indicating that females avoid sun exposure to a greater extent than males, possibly explaining the lower vitamin D status. Moreover, the authors reported that a significant negative correlation also existed between SAI and vitamin D status (Pearson's r = -0.33; p < 0.01), but no significant association was evident between vitamin D status and body mass index (Pearson's r = 0.03; p = 0.33) or low dietary intake of vitamin D-fortified foods (Pearson's r = 0.08; p = 0.13). The mean serum 25(OH)D concentration for females tested in winter was 31.3 ± 12.3 nmol/L while in the summer, it was 20.9 ± 14.9 nmol/L. This difference was statistically significant, suggesting that seasonal variation plays an important role in vitamin D status in the United Arab Emirates. The authors concluded that fortification of foods and drinks with vitamin D, supplementation and sensible sun exposure are important steps toward minimizing vitamin D deficiency.In the following article, Jörg Dötsch 5 analyzes the association of low birth weight, bone metabolism and fracture risk. HeThe human skin is a fascinating organ, representing both the site of production of a multitude of different hormones and an important target tissue for their pleiotropic biologic effects. Correlatives for many of the classical endocrine pathways, including parathyroid hormone relate...

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confidence: 99%

Hormones and skin: A never ending love story!

Reichrath¹

2011

Dermato-Endocrinology

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Metabolic Disorders

Kornreich¹

2015

Dermatological Manifestations of Kidney Disease

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MicroRNA/mRNA regulatory networks in the control of skin development and regeneration

Botchkareva

2012

Cell Cycle

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Skin development, postnatal growth and regeneration are governed by complex and well-balanced programs of gene activation and silencing. The crosstalk between small non-coding microRNAs (miRNAs) and mRNAs is highly important for steadiness of signal transduction and transcriptional activities as well as for maintenance of homeostasis in many organs, including the skin. Recent data demonstrated that the expression of many genes, including cell type-specific master transcription regulators implicated in the control of skin development and homeostasis, is regulated by miRNAs. In addition, individual miRNAs could mediate the effects of these signaling pathways through being their downstream components. In turn, the expression of a major constituent of the miRNA processing machinery, Dicer, can be controlled by cell type-specific transcription factors, which form negative feedback loop mechanisms essential for the proper execution of cell differentiation-associated gene expression programs and cell-cell communications during normal skin development and regeneration. This review summarizes the available data on how miRNA/mRNA regulatory networks are involved in the control of skin development, epidermal homeostasis, hair cycle-associated tissue remodeling and pigmentation. Understanding of the fundamental mechanisms that govern skin development and regeneration will contribute to the development of new therapeutic approaches for many pathological skin conditions by using miRNA-based interventions.

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Scleroderma-like skin changes not involving the hand in a prepubertal male with type I diabetes mellitus

Cited by 3 publications

References 5 publications

Hormones and skin: A never ending love story!

Hormones and skin: A never ending love story!

Metabolic Disorders

MicroRNA/mRNA regulatory networks in the control of skin development and regeneration

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