Sclérodermie généralisée et affections malignes: une revue de la littérature

Multilobated B cell lymphoma (Pinkus variant) with isolated muscular localization in a patient with systemic sclerosis: a case report

“…Various malignancies have been described in association with SSc: lung cancer, breast cancer, and haematologic malignancies [2,3,4,6,9,10]. Although a pathogenetic link with SSc seems to be present in the case of lung cancer, this is highly doubtful for lymphoproliferative disorders [2,10].…”

“…Although a pathogenetic link with SSc seems to be present in the case of lung cancer, this is highly doubtful for lymphoproliferative disorders [2,10]. The association of SSc and NHL might be fortuitous or might depend on the emergence of a transformed lymphoid clone in a situation of chronic B lymphocyte hyperstimulation and proliferation, as happens in many autoimmune disorders.…”

“…The association of systemic sclerosis (SSc) and hematologic malignancies, mainly non-Hodgkin's lymphoma (NHL), is a rare event, the pathogenetic aspects of which have not yet been clarified [2]. Malignant lymphoproliferation may be present initially or may develop later in the illness, and most of the lymphomas seem to be of B-cell lineage, although their histologic appearance is variable.…”

Uncommon clinical presentation of a lymphocytic lymphoma of intermediate differentiation in a patient with systemic sclerosis

“…Whether or not the association of systemic sclerosis (SSc) and neoplasms is fortuitous is a much-debated subject. Although various malignancies have been described in association with SSc (such as lung and breast cancer, malignant haemopathies and gastrointestinal tumours), it is only in the case of lung cancer that statistical data seem to support the notion of a possible pathogenetic relationship (Bielefeld. 1991;Roumm & Medsger, 1985).…”

“…The association of SSc and non-Hodgkin lymphoma is a rare event. No more than 30 cases have been reported (Bielefeld, 1991) and, given that they are not extensively described, it is difficult to know the frequency of an association with the relatively new clinico-pathological entity of IDL; there are, however, no reports in the literature.…”