Sclérodermie systémique associée à l’exposition à la silice survenant après une exposition professionnelle à la soudure à l’arc

Alaya, Zeineb; Kalboussi, Houda; Osman, Walid; Naouar, Nader; Zeglaoui, H.; Bouajina, E.

doi:10.11604/pamj.2016.25.70.10390

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Emerging evidence has demonstrated that the human gut microbiota can confer either health benefits or a susceptibility to disorders.It has been reported that exposure to silica was associated with occurrence of systemic sclerosis [29]. Furthermore, Andreasson K et al analyzed the prevalence of intestinal dysbiosis in systemic sclerosis patients and indicated that a majority(75.5%) of the patients exhibited intestinal dysbiosis, which was more severe in patients with pulmonary fibrosis [30].…”

Section: Discussionmentioning

confidence: 99%

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Zhou¹,

Lv²,

Sun

et al. 2019

J Occup Med Toxicol

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Silicosis resulting from silica exposure is a global occupational disease characterized by severe pathological changes in progressive pulmonary fibrosis. Previous evidence has indicated that dysbiosis of the gut microbiota occurs after environmental dust exposure and is associated with certain diseases. The aims of this study are to elucidate the compositional and functional characteristics of the gut microbiota in early-stage silicosis and to understand their influence on pulmonary fibrosis. We investigated the gut microbial composition of fecal samples from 18 patients and 21 healthy subjects using 16S rRNA gene sequencing technology. Compared with the healthy subjects, reductions in the levels of Firmicutes and Actinobacteria were noted in patients with silicosis and progressive pulmonary fibrosis, as well as lower levels of Devosia, Clostridiales, AlloprevotellaandRikenellaceae_RC9. Lachnospiraceae and Lachnoclostridium levels were increased in patients with silicosis. GOC and KEGG analyses were used to predict that certain bacteria taxa play critical roles in the development of pulmonary fibrosis, including posttranslational modification, amino acid transport and metabolism, nucleotide transport and metabolism, and ribosomal structure and biogenesis. KEGG analysis showed that certain taxa participate in various roles including cancer, endocrine metabolism, immune system, signaling molecules and interaction, and transcription. Collectively, in this pilot study, microbiota changes have been represented in the gut of patients with silicosis. Although this change in gut microbiota have been represented, caution is needed when interpreting the findings since this is observational finding, not necessarily causative. More studies should be performed in the expanding population to be verified and more studies underlying biological mechanisms for better understanding the relationship between gut microbiota and development of pulmonary fibrosis in patients with silicosis.

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Section: Discussionmentioning

confidence: 99%

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Zhou¹,

Lv²,

Sun

et al. 2019

J Occup Med Toxicol

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Pulmonary Diseases in Refugees and Migrants in Europe

et al. 2018

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More than 2 million people fleeing conflict, persecution, and poverty applied for asylum between 2015 and 2016 in the European Union. Due to this, medical practitioners in recipient countries may be facing a broader spectrum of conditions and unusual presentations not previously encountered, including a wide range of infections with pulmonary involvement. Tuberculosis is known to be more common in migrants and has been covered broadly in other publications. The scope of this review was to provide an overview of exotic infections with pulmonary involvement that could be encountered in refugees and migrants and to briefly describe their epidemiology, diagnosis, and management. As refugees and migrants travel from numerous countries and continents, it is important to be aware of the various organisms that might cause disease according to the country of origin. Some of these diseases are very rare and geographically restricted to certain regions, while others have a more cosmopolitan distribution. Also, the spectrum of severity of these infections can vary from very benign to severe and even life-threatening. We will also describe infectious and noninfectious complications that can be associated with HIV infection as some migrants might originate from high HIV prevalence countries in sub-Saharan Africa. As the diagnosis and treatment of these diseases can be challenging in certain situations, patients with suspected infection might require referral to specialized centers with experience in their management. Additionally, a brief description of noncommunicable pulmonary diseases will be provided.

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Erasmus Syndrome: A Case Report and Literature Review

et al. 2022

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Patient: Male, 40-year-old Final Diagnosis: Erasmus syndrome • silicosis • systemic sclerosis Symptoms: Arthralgia • back pain • exertional dyspnea • Raynaud’s phenomenon • skin changes • weight loss Medication: — Clinical Procedure:— Specialty: Pulmonology • Rheumatology Objective: Rare disease Background: Erasmus syndrome is a rare disease entity characterized by the development of systemic sclerosis (SSc) in a background of silica exposure or silicosis. Case Report: We report the case of a 40-year-old Filipino man who previously worked in a silica grind mill for 10 years and eventually developed Erasmus syndrome. The patient initially presented with chronic back pain in 2018 associated with findings of pulmonary tuberculosis on chest X-ray, with notable improvement after 6 months of anti-tuberculosis treatment. However, his back pain recurred in 2021; this time with arthralgia, Raynaud’s phenomenon, thickening of both hands, skin hypopigmentation on the chest, back, and forehead, and exertional dyspnea. Physical examination revealed salt-and-pepper dermopathy and skin tightening over the back, chest, and extremities. Mobility of his hands was limited, associated with sclerodactyly and digital pitting. Antinuclear antibody-immunofluorescence and anti-scleroderma-70 antibodies were strongly positive, confirming the diagnosis of SSc. Chest computed tomography illustrated multiple subcentimeter nodules and enlarged mediastinal lymph nodes with eggshell calcifications, consistent with silicosis. Spirometry with body plethysmography was normal but diffusing capacity for carbon monoxide was severely reduced. Histopathology of the skin showed markedly thickened collagen bundles in the dermis. Conclusions: Chronic silica exposure is a risk factor for the development of silicosis. The clinical course of patients with silicosis may be complicated by SSc. Maintaining a high index of suspicion is key to the diagnosis of Erasmus syndrome. The present report emphasizes the importance of preventive measures and surveillance among those with occupational exposure to silica. To our knowledge, this is the first documented case of Erasmus syndrome in the Philippines.

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Sclérodermie systémique associée à l’exposition à la silice survenant après une exposition professionnelle à la soudure à l’arc

Cited by 3 publications

References 13 publications

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Pulmonary Diseases in Refugees and Migrants in Europe

Erasmus Syndrome: A Case Report and Literature Review

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