Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases?

Julià, Marc; Mascaró, José M.; Guilabert, Antonio; Navarra, Esperanza; Ferrando, Juan; Herrero, Carmen

doi:10.1016/j.jaad.2007.06.044

Cited by 26 publications

(20 citation statements)

References 13 publications

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“…The occurrence of clinical and histopathological features of both chronic cutaneous lupus erythematosus and morphea in the same lesion was first described by Umbert and Winkelmann in 1978 4 . Since then, only two other cases have been reported based on the results of a Medline search 5,6 . All the cases previously described were female (Table 1).…”

Section: Discussionmentioning

confidence: 83%

“…While CCLE is usually associated with the development of coin‐shaped or disk‐like discoid lesions, development of lesions with linear distribution is unusual 3 . The coexistence of CCLE and localized scleroderma in the same lesion with linear distribution is exceedingly rare and has only been reported in a few patients 4–6 . The term “sclerodermiform linear lupus erythematosus” has been suggested 4 …”

Section: Introductionmentioning

confidence: 99%

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Linear sclerodermic lupus erythematosus, a distinct variant of linear morphea and chronic cutaneous lupus erythematous

Khelifa¹,

Masouyé²,

Pham³

et al. 2011

Int J Dermatology

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Linear sclerodermic lupus erythematosus, a distinct variant of linear morphea and chronic cutaneous lupus erythematous

Khelifa¹,

Masouyé²,

Pham³

et al. 2011

Int J Dermatology

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“…Umbert and Winkelmann[9] Marzano et al .,[10] and Julià et al . [11] also reported such association but lesions were on the arms rather than over face. All cases were treated with oral antimalarials and topical steroids with partial improvement.…”

Section: Discussionmentioning

confidence: 97%

Parry-Romberg syndrome: A linear variant of scleroderma with discoid lupus erythematosus on scalp - an association

2014

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Parry-Romberg syndrome is a rare neurocutaneous syndrome characterized by progressive shrinkage and degeneration of the tissues beneath the skin, usually on one side of the face. It is associated with neurological disorders such as trigeminal neuralgia, facial paresthesia, headache, and focal epilepsy. Concomitant occurrence of discoid lupus erythematosus (DLE) and morphea in the same skin lesion is exceptional, defined as overlap syndrome with two or more different connective tissue disease concurrently or consecutively. A 32-year-old female developed DLE on a long-standing lesion of scleroderma over left temporal area with characteristics histopathological changes. She was treated with oral antimalarials and steroids which halted the progress of the disease.

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“…2 Two similar cases in which these two pathologies with a linear pattern of involvement overlapped have been described previously. 3 Linear involvement in cutaneous LE is rare and may present as LDLE, deep LE, tumid LE or SCLE. 2 A case of linear bullous LE has been described in a patient with SLE.…”

Section: Discussionmentioning

confidence: 99%

“…5,6,12 The cells arising from these mosaicisms express neoantigens capable of eliciting local immune response. 3 The trigger for the onset of the disease may be trauma, primary irritation or exogenous agents such as ultraviolet light, drugs, pesticides, heavy metals or other elements. 2,14 The apoptosis of keratinocytes has been indicated as a key event in triggering cutaneous lupus lesions through various apoptotic pathways such as p53, tumor necrosis factor-alpha (TNF-α) and Fas/FasL.…”

Section: Discussionmentioning

confidence: 99%

Lúpus eritematoso crônico discoide nas linhas de Blaschko

Daldon

Lage

2011

An. Bras. Dermatol.

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Linear chronic discoid lupus erythematosus is a rare manifestation of cutaneous lupus in which erythematous, atrophic, dyschromic lesions are located along the lines of Blaschko. This report describes the case of a 15-year old boy with a 2-year history of discoid, erythematous, hyper and hypopigmented lesions with central atrophy, situated along the lines of Blaschko on his right arm. Histopathology showed epidermal atrophy, hyperkeratosis, follicular plugging, thickening of the basement membrane zone, and superficial and deep chronic perivascular and periadnexal inflammatory infiltrate, with dermal mucin deposit, thus confirming diagnosis. A total of 14 cases have been described of this variant, the onset of which is often in childhood. There is no difference in incidence between genders. Lesions most commonly develop on the face. There have been no reports of any association with systemic disease. Keywords: Lupus erythematosus, cutaneous; Lupus erythematosus, discoid; Mosaicism Resumo: O lúpus eritematoso crônico discoide linear é manifestação rara da doença lúpica cutânea, em que lesões eritêmato-atrófico-discrômicas dispõem-se nas linhas de Blaschko. Descrevemos o caso de um menino de 15 anos, com dois anos de história de lesões discoides eritêmato-atróficas, hipo e hiperpigmentadas, dispostas nas linhas de Blaschko do membro superior direito. O exame histopatológico revelou atrofia da epiderme, hiperqueratose, rolhas córneas, espessamento da zona da membrana basal, infiltrado inflamatório crônico perianexial e perivascular superficial e profundo, depósito de mucina na derme, confirmando o diagnóstico. Há, no total, 14 casos descritos dessa variante que se inicia frequentemente na infância e que não apresenta predomínio quanto ao sexo. As lesões ocorrem preferencialmente na face. Não há relatos de associação com doença sistêmica. Palavras-chave: Lupus eritematoso cutâneo; Lupus eritematoso discóide; Mosaicismo

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Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases?

Cited by 26 publications

References 13 publications

Linear sclerodermic lupus erythematosus, a distinct variant of linear morphea and chronic cutaneous lupus erythematous

Linear sclerodermic lupus erythematosus, a distinct variant of linear morphea and chronic cutaneous lupus erythematous

Parry-Romberg syndrome: A linear variant of scleroderma with discoid lupus erythematosus on scalp - an association

Lúpus eritematoso crônico discoide nas linhas de Blaschko

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