Sclerosing adenocarcinoma of the extrahepatic bile duct in a cat

Pastor, Josep; Majó, Natàlia; Arbona, Cristina; García, Felipe Martínez; Velarde, Roser; Pumarola, M.; Lavin, S.

doi:10.1136/vr.140.14.367

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Extrahepatic biliary tract obstruction is uncommon in cats . Reported causes in cats have included inflammatory diseases (involving the common bile duct, pancreas, or duodenum), neoplastic processes (involving the common bile duct, liver, pancreas, or duodenum), plugs/colelithiasis causing intraluminal obstruction of the common bile duct, proximal duodenal foreign bodies (causing an obstruction at the level of the major duodenal papilla), diaphragmatic hernia, liver fluke infestation, and congenital abnormalities . To the authors’ knowledge, obstruction of the biliary tract by an intraluminal foreign body within the common bile duct has not previously been reported in cats.…”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis—extrahepatic Biliary Tract Obstruction Secondary to a Biliary Foreign Body in a Cat

Brioschi

Rousset

Ladlow

2013

Vet Radiology Ultrasound

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An 11-year-old, neutered female British Shorthair cat was referred with a 4-week history of abdominal pain and vomiting. Abdominal ultrasonography revealed a dilated common bile duct containing a spindle-shaped structure with several reflecting interfaces. Differentials that were considered included an intraluminal foreign body, or helminth parasites within the common bile duct. Surgical exploration of the abdominal cavity demonstrated the presence of two grass awns obstructing the common bile duct. Anomalies of the portal vasculature were noted during surgery and were considered an incidental finding. The clinical signs resolved following surgical removal of the grass awns.

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Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis—extrahepatic Biliary Tract Obstruction Secondary to a Biliary Foreign Body in a Cat

Brioschi

Rousset

Ladlow

2013

Vet Radiology Ultrasound

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“…Neoplasia arising from the CBD, pancreas or proximal duodenum is a less common cause of extrahepatic biliary obstruction (EHBO) (Figure 11). 21,42–46 It is often not possible to definitively differentiate between an obstructive mass caused by inflammation and a neo-plastic mass since both conditions can share similar features on ultrasound. 15…”

Section: Abnormalities Of the Biliary Treementioning

confidence: 99%

“…Neoplasia arising from the CBd, pancreas or proximal duodenum is a less common cause of extrahepatic biliary obstruction (EHBo) ( Figure 11). 21,[42][43][44][45][46] it is often not possible to definitively differentiate between an obstructive mass caused by inflammation and a neoplastic mass since both conditions can share similar features on ultrasound. 15 Extrahepatic biliary obstruction obstruction of the CBd frequently occurs close to or at the level of the duodenal papilla 15 and can arise as a result of mural thickening, extraluminal compression or obstruction of the lumen.…”

Section: G a L L B L A D D E R S L U D G Ementioning

confidence: 99%

Feline abdominal ultrasonography: what’s normal? what’s abnormal? The biliary tree

Griffin

2019

Journal of Feline Medicine and Surgery

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Practical relevance: Abdominal ultrasound plays a vital role in the diagnostic work-up of many cats presenting to general and specialist practitioners. The biliary tree encompasses the liver, gall bladder and bile ducts, although only diseases affecting the latter two are discussed here. Diseases of the bile ducts and gall bladder are more common than those of the liver parenchyma and ultrasound plays an important role in their diagnosis. Clinical challenges: Despite ultrasonography being a commonly used modality, many practitioners are not comfortable performing an ultrasound examination or interpreting the resulting images. Even differentiating between normal variation and pathological changes can be challenging for all but the most experienced. In addition, a lack of pathological change does not necessarily rule out disease; for example, absence of gall bladder and/or extrahepatic biliary distension is not sufficient to exclude the possibility of biliary obstruction, and in many cases of cholangitis the liver and biliary tree are unremarkable on ultrasound examination. Equipment: Ultrasound facilities are readily available to most practitioners, although use of ultrasonography as a diagnostic tool is highly dependent on operator experience. Aim: This review, part of an occasional series on feline abdominal ultrasonography, discusses the appearance of the normal and diseased biliary system. It is aimed at general practitioners who wish to improve their knowledge and confidence in feline abdominal ultrasound and is accompanied by high-resolution images. Percutaneous ultrasound-guided cholecystocentesis is also covered. Ultrasound examination of the liver was discussed in an article published in January 2019 and an upcoming article will cover hepatic vascular anomalies. Evidence base: Information provided in this article is drawn from the published literature and the author’s own clinical experience.

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“…1 In the present case, gross and microscopic changes in the liver and associated signs of icterus and photodermatitis can be attributed to partial to complete obstruction of normal outflow of the bile through the biliary system. Obstructive icterus has also been described in bears, 7 humans, 10 and cats 2,12 affected by carcinomas of extrahepatic biliary ducts. Long-standing, extrahepatic cholestasis can cause progressive dilation of bile ducts with accompanying biliary hyperplasia in the portal areas and hepatocellular injury due to retention of bile constituents.…”

mentioning

confidence: 99%

“…4 In cattle, epithelial tumors of the intrahepatic biliary ducts and gallbladder have been reported as incidental findings in retrospective studies carried out in slaughterhouses. 1 , 14 Epithelial tumors of the extrahepatic biliary tree have been reported in animals on rare occasions, including bile duct carcinomas in bears, 7 sea otters, 13 cats, 2 , 12 and dogs. 3 This is in contrast to the much higher prevalence of carcinomas of the extrahepatic biliary tract reported in humans.…”

mentioning

confidence: 99%

Papillary Adenocarcinoma of the Extrahepatic Bile Duct in a Holstein Cow

Ilha¹,

Loretti²,

Barros³

et al. 2005

Vet Pathol

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Abstract.A 15-year-old female Holstein cow was presented with a history of anorexia and weight loss. Abnormal physical examination findings included poor body condition, dehydration, icterus, and photodermatitis on nonpigmented areas of the skin of the dorsum. At necropsy, the common bile duct was greatly enlarged, with thickened walls, and tightly adhered to the hepatic capsular surface and serosa of adjacent loops of the small intestine. Two sessile, yellowish, friable, well-circumscribed, cauliflower-like, bulging masses (14 and 8 cm in diameter) were attached to the inner surface of the common bile duct blocking its lumen. Microscopically, the tumor was composed of well-differentiated, columnar epithelial cells with oval or round, vesicular, basal nuclei arranged in papillary projections. Periodic acid-Schiff-positive material accumulated in the apical cytoplasm of the neoplastic cells. Immunostaining of the tumor cells was positive for cytokeratin (CK) of widespectrum screening and for CK 7. The diagnosis of papillary adenocarcinoma of the extrahepatic bile duct was based on the morphologic features of the neoplasm and evidence of local invasion. To the best of our knowledge, extrahepatic bile duct carcinomas have not been described in cattle.

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Sclerosing adenocarcinoma of the extrahepatic bile duct in a cat

Cited by 8 publications

References 10 publications

Imaging Diagnosis—extrahepatic Biliary Tract Obstruction Secondary to a Biliary Foreign Body in a Cat

Imaging Diagnosis—extrahepatic Biliary Tract Obstruction Secondary to a Biliary Foreign Body in a Cat

Feline abdominal ultrasonography: what’s normal? what’s abnormal? The biliary tree

Papillary Adenocarcinoma of the Extrahepatic Bile Duct in a Holstein Cow

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