Sclerosing Angiomatoid Nodular Transformation of the spleen, focal nodular hyperplasia and hemangioma of the liver: A tale of three lesions

Cafferata, Barbara; Pizzi, Marco; D’Amico, F.; Mescoli, Claudia; Alaggio, Rita

doi:10.1016/j.prp.2016.07.003

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…In the present review, coexistent malignancy (2 cases each of colon cancer and breast cancer and 1 each of ovarian cancer, cervical carcinoma, ductal carcinoma of the pancreas, intracystic papillary carcinoma, hypopharynx carcinoma, early gastric cancer with gastrointestinal stromal tumor of the jejunum, and papillary thyroid carcinoma) was present in 11 of 71 cases (15.5%), which is quite similar to the previously reported rates (9). As in the present case, it is likely that the diagnostic modalities used during follow-up or staging estimation contributed to the detection of incidental SANT in terms of the frequency of associated neoplastic lesions.…”

Section: Discussionsupporting

confidence: 90%

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Sclerosing Angiomatoid Nodular Transformation of the Spleen: Lessons from a Rare Case and Review of the Literature

et al. 2019

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Sclerosing angiomatoid nodular transformation (SANT) of the spleen is an extremely rare benign lesion. We herein report a case of asymptomatic SANT of the spleen in a middle-aged woman with early breast carcinoma and an undiagnosed splenic mass, which was successfully treated by laparoscopic splenectomy and diagnosed postoperatively. We also review the literature on SANT to help make knowledge more accessible when clinicians encounter a splenic tumor. The present case taught us the following lesson: the presence of a splenic lesion during follow-up for malignancy is not always indicative of metastasis. Therefore, SANT should be considered in the differential diagnosis.

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Section: Discussionsupporting

confidence: 90%

“…The reported comorbidities in this case series seem non-specific to SANT, as two patients had hypertension, four each had diabetes and hepatic cysts, two had anemia, and other comorbidities appeared in single patients. SANT has been reported to coexist with abdominal or extra-abdominal tumors in up to 14% of cases (9).…”

Section: Discussionmentioning

confidence: 99%

Sclerosing Angiomatoid Nodular Transformation of the Spleen: Lessons from a Rare Case and Review of the Literature

et al. 2019

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“…Anyway, there is a significant intraperitoneal [ 6 , 15 ] dissemination risk if the biopsied lesion proves to be angiosarcoma and have other complications (splenic rupture and bleeding). The etiopathogenesis is still unknown, but several causes are hypothesized: Epstein-Barr virus association [ 16 ], red pulp abnormal transformation due to stromal proliferation, or hamartomas/inflammatory pseudoneoplasm final stage [ 6 , 17 ]. Finally, in recent studies [ 18 ], it is noted that SANT proliferation could be associated to the typical sclerosing injuries of the disorder related to immunoglobulin G4 (IgG4).…”

Section: Discussionmentioning

confidence: 99%

Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

Cipolla

Florena

Ferrara

et al. 2018

Case Reports in Surgery

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Introduction Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular lesion with unknown etiopathogenesis and with definite features of imaging, histopathology, and immunohistochemistry. It was first described by Martel et al. in 2004, and to date, only 151 cases have been reported. Case Description We report a case of SANT of the spleen detected in a 66-year-old Caucasian, without comorbidities, presented to our department with epigastric pain. We, also, presented a review of the literature. Conclusions SANT is a benign incidentally vascular condition in the majority of cases. The wide age and gender distribution in our review is in accordance with that in previous studies in English literature. In our opinion, splenectomy is the choice treatment because it is at the same time diagnostic and therapeutic in a definitive way.

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“…Although the pathogenesis and long-term natural history of SANT remain unknown, several hypotheses for the pathogenesis of SANT have been proposed, such as association with Epstein-Barr virus infection, transformation of red marrow anomalies due to stromal growth, and the final stage of hamartoma/inflammatory pseudotumor [3][4][5][6]. Recent studies have reported that SANT proliferation may be related to immunoglobulin G4 (IgG4) [6, 7].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Splenectomy in a Patient with Sclerosing Angiomatoid Nodular Transformation

Kusano¹,

Ryu²,

Matsuo³

et al. 2020

Case Rep Gastroenterol

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Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a specific, tumor-forming, non-neoplastic, vascular lesion with few reported cases worldwide. Herein, we describe the case of a patient who underwent laparoscopic splenectomy for SANT. A 47-year-old woman underwent upper gastrointestinal endoscopy for suspected gastric submucosal tumor. Contrast-enhanced abdominal computed tomography revealed the presence of a gradually enhancing lesion in the splenic hilum. Although we suspected splenic fibrotic hamartoma, malignancy could not be ruled out. Therefore, the patient underwent laparoscopic splenectomy, resulting in the histopathological diagnosis of SANT. Although SANT is a benign tumor, it may be difficult to obtain definitive diagnosis using preoperative imaging alone. Because the longterm natural history of SANT is unknown, we believe that splenectomy could be an appropriate technique for the diagnosis and treatment of SANT.

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Sclerosing Angiomatoid Nodular Transformation of the spleen, focal nodular hyperplasia and hemangioma of the liver: A tale of three lesions

Cited by 6 publications

References 31 publications

Sclerosing Angiomatoid Nodular Transformation of the Spleen: Lessons from a Rare Case and Review of the Literature

Sclerosing Angiomatoid Nodular Transformation of the Spleen: Lessons from a Rare Case and Review of the Literature

Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

Laparoscopic Splenectomy in a Patient with Sclerosing Angiomatoid Nodular Transformation

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