Sclerosing angiomatoid nodular transformation of spleen in 8-year old girl

Jamal, Ammarah; Siddique, Uzma; Rehman, Saifur; Arain, Mustafa A.; Hamid, Ahmer

doi:10.5455/jpma.31769

Cited by 3 publications

(7 citation statements)

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“…In previous literatures, SANT mainly occurs in middle-aged population with a slightly female inclination and the mean age at onset was 50 years, which is also supported in our case [5]. However, occurrence of SANT shows a young age trends in recent report [6,7]. Youngest SANT patient was a 7-month-old infant with splenomegaly [8].…”

Section: Discussionsupporting

confidence: 86%

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Yang

Zhang

Peng

et al. 2020

Preprint

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BACKGROUND: Sclerosing angiomatoid nodular transformation of the spleen is one kind of exceedingly rare benign lesions originated from spleen. The incidence and pathogen remain unclear partially due to its rarity and short history. Consequently, preoperative diagnosis become extremely perplex. Splenectomy is a predominated therapy approach as well as diagnosis method for sclerosing angiomatoid nodular transformation of the spleen. We reported a case underwent computed tomography scan, magnetic resonance imaging and ultrasonic scan preoperatively. Examinations conclusion highly suspected sclerosing angiomatoid nodular transformation of the spleen and was confirmed by pathology after laparoscopic splenectomy. We herein reviewed some literatures on imaging characters of to reveal the possibility of preoperative diagnosis when clinicians encounter and investigated whether laparoscopic splenectomy is an appropriate treatment.CASE PRESENTATION: A 50-year-old female was found with a low dense mass in the spleen by abdominal computed tomography incidentally without any positive symptom. Further enhanced computed tomography scan revealed the lesion with asynchronous enhancement and magnetic resonance imaging showed radio-like rift missing from central. Ultrasonic scan imaging presented hypoechoic gap in the center, pretty similar to magnetic resonance imaging. These radiology imaging features deduced to Sclerosing angiomatoid nodular transformation of the spleen. Laparoscopic splenectomy was performed successfully by our team and histopathological findings convinced the preoperative diagnosis. Gross inspection was coincident to the performance of magnetic resonance imaging.CONCLUSION: By comprehending imaging character profoundly, sclerosing angiomatoid nodular transformation of the spleen can be a differential diagnosis preoperatively when encounter lesion of spleen. We believe that laparoscopic splenectomy is a reliable and effective therapy option for such rare benign lesion of spleen without risk of recurrence.

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Section: Discussionsupporting

confidence: 86%

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Yang

Zhang

Peng

et al. 2020

Preprint

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“…On imaging (enhanced CT and MRI) some SANT can present a characteristic "spoke wheel" sign, as in two of our cases (Fig. 3C), which corresponds with the macroscopic central white stellate dense scar projecting to periphery [24,25]. There are 3 distinct types of vessels in the angiomatoid nodules: CD34 + /CD8 − /CD31 + capillaries, CD34 − /CD8 + / CD31 + sinusoids, and CD34 − /CD8 − /CD31 + small veins, resembling the composition of normal splenic red pulp [23,24].…”

Section: Extremely Rare Conditions Do Exist In Pediatric Benign Splen...supporting

confidence: 65%

“…Most reported cases are adults, but SANT can occur in children although very rare [24]. The macroscopic view of SANT shows multiple red-brown nodules scattered in a dense white fibrocalcific stroma, and the fibrous stroma often appears in a stellate form projecting from the center to the periphery [24]. On imaging (enhanced CT and MRI) some SANT can present a characteristic "spoke wheel" sign, as in two of our cases (Fig.…”

Section: Extremely Rare Conditions Do Exist In Pediatric Benign Splen...supporting

confidence: 55%

“…SANT is a non-neoplastic benign vascular lesion of the spleen first reported in 2004 by Martel [23]. Most reported cases are adults, but SANT can occur in children although very rare [24]. The macroscopic view of SANT shows multiple red-brown nodules scattered in a dense white fibrocalcific stroma, and the fibrous stroma often appears in a stellate form projecting from the center to the periphery [24].…”

Section: Extremely Rare Conditions Do Exist In Pediatric Benign Splen...mentioning

confidence: 99%

“…3C), which corresponds with the macroscopic central white stellate dense scar projecting to periphery [24,25]. There are 3 distinct types of vessels in the angiomatoid nodules: CD34 + /CD8 − /CD31 + capillaries, CD34 − /CD8 + / CD31 + sinusoids, and CD34 − /CD8 − /CD31 + small veins, resembling the composition of normal splenic red pulp [23,24]. These features are distinct from vascular malformation and endothelial neoplasm.…”

Section: Extremely Rare Conditions Do Exist In Pediatric Benign Splen...mentioning

confidence: 99%

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Surgical treatment of benign splenic lesions in pediatric patients: a case series of 30 cases from a single center

Wang

Peng

et al. 2022

BMC Surg

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Background Benign splenic lesions are rarely encountered. This study aimed to review the clinical characteristics and surgical outcomes in a case series of 30 pediatric patients. Methods From January 1st, 2001 to December 31st, 2021, 30 pediatric patients from a single center were consecutively included. Electronic medical records were reviewed and patients were followed up. Clinical presentations, imaging features, surgical procedures, pathological diagnoses, and prognoses were summarized. The lesion locations and 7-day postoperative platelet levels were compared between total and partial splenectomy patients. Results Eighteen males and twelve females were included, with mean age at surgery 116.4 ± 43.6 months. The clinical presentations included abdominal pain (16/30), splenomegaly (6/30), skin petechia (2/30), hemolytic jaundice (1/30), and no symptoms (5/30). Pathological diagnoses included congenital epithelial cyst (CEC, 17/30), vascular malformation (8/30), sclerosing angiomatoid nodular transformation (SANT, 3/30), hamartoma (1/30), and leiomyoma (1/30). Patients undergone total splenectomy were more likely to have a lesion involving the hilum than those undergone partial splenectomy (68.4% vs 31.6%, P = 0.021). The 7-day postoperative platelet level was higher in total splenectomy patients than partial splenectomy patients (adjusted means 694.4 × 109/L vs 402.4 × 109/L, P = 0.002). Conclusions Various clinical characteristics of pediatric benign splenic lesions are summarized. The most common pathological diagnoses are congenital epithelial cyst and vascular malformation. Partial and total splenectomy result in good prognosis with a low recurrence rate, and the former is preferred to preserve splenic function if possible.

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Transformación nodular angiomatoide esclerosante de bazo: Reporte de caso

Nieto-Yrigoin,

Luna-Cydejko,

Revoredo- Rego

et al. 2024

Interciencia méd.

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La transformación nodular angiomatoide esclerosante (SANT) es una rara patología vascular benigna primaria del bazo. La mayoría de personas son asintomáticos, constituyendo hallazgos incidentales en los estudios radiológicos. El diagnóstico definitivo es a través de la anatomopatología. La esplenectomía es el tratamiento de elección. Presentamos un caso de SANT que apareció como un hallazgo incidental de una masa esplénica al realizar una Tomografía computarizada.

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Sclerosing angiomatoid nodular transformation of spleen in 8-year old girl

Cited by 3 publications

References 0 publications

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Surgical treatment of benign splenic lesions in pediatric patients: a case series of 30 cases from a single center

Transformación nodular angiomatoide esclerosante de bazo: Reporte de caso

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