Sclerosing angiomatoid nodular transformation of the spleen in an adolescent with chronic abdominal pain

Sclerosing Angiomatoid Nodular Transformation of the Spleen in Children: A case report and review of the literature

“…Our case described a rare finding of SANT in the paediatric population with histological characteristics of slit-like or irregular shaped vascular spaces that was typical of SANT. Immunohistochemistry was positive for CD8-, CD31+ and CD34+, which was in keeping with results found in previous cases [2,9]. In addition, we also found CD240 to be positive.…”

“…SANT in children is exceptionally rare and review of the existing literature in children less than 18 years old revealed 4 patients, with a median age of 10.5 years (range: 3-17 years), of which 75% (n=3) males [2,3,10,11]. (Table1).…”

“…This case was followed up for 10 months with no concerning features, including all cases in the reviews [2,11]. Although fatality from SANT is rear, 2 cases were reported in middle-aged adult, both had a co-existent of malignancy and the cause of death was due to sepsis and complications of cancer respectively [5].…”

“…Sclerosingangiomatoid nodular transformation (SANT) is a rare and benign primary vascular lesion of the spleen with of the spleen unknown aetiology and pathogenesis [1]. Its diagnosis is often incidental and it's characterised by numerous angiomatoid nodules in fibrous tissue, within the red pulp of the spleen [2,3]. The neoplasm has shown a predilection for adult females [4].…”

A case of sclerosing angiomatoid nodular transformation of the spleen with increased accumulation of fluorodeoxyglucose after 5-year follow-up

“…Nevertheless, the high frequency of complications such as bleeding or splenic rupture was noted after percutaneous biopsy of vascular splenic regions. To the best of our knowledge, there were six cases reported in English literatures that were diagnosed as a SANT by imaging study and follow-up, and operations were finally completed, according to the growing mass ( Table 1 ) [14] , [15] , [16] , [17] , [18] , [19] . The follow-up period ranged from 3 to 36 months.…”