Sclerosing Carcinoma of the Major Intrahepatic Bile Ducts

Altemeier, William A.; Gall, Edward A.; Zinninger, M. M.; Hoxworth, Paul I.

doi:10.1001/archsurg.1957.01280150140015

Cited by 181 publications

(74 citation statements)

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“…The following variables were collected for analysis: (1) sex; (2) primary site (location of the primary lesion [IH-CCC v EH-CCC] judged on explant pathological characteristics; tumor foci originating in EH bile ducts were classified as such, whereas all other proximal lesions were classified as IH); (3) other organ invasion (microscopic or macroscopic invasion into contiguous organs [present v absent]; note that invasion of the liver by hilar CCC was not regarded as positive); (4) Overall and disease-free survival rates were calculated according to the Kaplan-Meier method. Disease-free survival was death censored for non-cancer-related mortality.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Histologically, most CCCs are adenocarcinomas, 1 and classification based on location classically has been applied. 4,5 Intrahepatic (IH) or peripheral CCC arises from IH bile ducts and is the second most common primary liver cancer behind hepatocellular carcinoma (HCC). 3 Extrahepatic (EH)-CCC arises from the biliary tree outside the liver parenchyma and also has been referred to as bile duct carcinoma, hilar, or central CCC.…”

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confidence: 99%

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Liver transplantation for cholangiocellular carcinoma: Analysis of a single-center experience and review of the literature

Shimoda

Farmer

Colquhoun

et al. 2001

Liver Transplantation

204

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Cholangiocellular carcinoma (CCC) is a biliary malignancy that frequently presents in advanced unresectable stages. The role of liver transplantation (LT) as a surgical modality is unclear. The goal of this study is to evaluate outcomes of patients with CCC undergoing LT. A retrospective analysis of all patients undergoing LT was undertaken. Only those patients with the pathological diagnosis of CCC were included on the study. Patients were divided into two groups based on primary tumor location: extrahepatic (EH)-CCC and intrahepatic (IH)-CCC. The Kaplan-Meier method was used to calculate overall and recurrence-free survival. Log-rank analysis was used to determine the significance of prognostic variables. Twenty-five patients were identified: 9 patients with EH-CCC (5 patients, Klatskin-type; 2 patients, the middle third; and 2 patients, the distal third) and 16 patients with IH-CCC. Mean age was 47.1 ؎ 10.6 years. There were 14 men and 11 women. Tumor stage was local (stages I and II; n ‫؍‬ 9) or advanced (stages III and IV; n ‫؍‬ 16). Overall and disease-free survival rates were 71% and 67% at 1 year and 35% and 32% at 3 years, respectively. Analysis of variables showed statistically significant improved outcomes (P < .05) for the absence of contiguous organ invasion at LT, small tumor size, and single tumor foci. This study indicates that early survival after LT for CCC is acceptable. Three-year disease-free survival is achieved in approximately 30% of patients. These outcomes can be improved by applying strict selection criteria based on prognostic variables identified in this study. (Liver Transpl 2001;7:1023-1033.)

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Liver transplantation for cholangiocellular carcinoma: Analysis of a single-center experience and review of the literature

Shimoda

Farmer

Colquhoun

et al. 2001

Liver Transplantation

204

View full text Add to dashboard Cite

show abstract

“…The remaining part of the bile duct is considered "extrahepatic," including the hilum of the liver. In the strictest sense, then, Ch-Ca is a cancer arising from the epithelium of the intrahepatic duct or ductules (27)(28)(29). Practically speaking, differentiation of intrahepatic from extrahepatic bile duct cancer is often difficult anatomically, particularly in the hepatic hilum, and the histologic characteristics of the two are identical.…”

Section: Discussionmentioning

confidence: 99%