Sclerosing mucoepidermoid carcinoma of the sublingual gland

Lee, D.H.; Kim, J.H.; Lee, J.K.; Lim, Sang Chul

doi:10.1016/j.anorl.2016.07.010

European Annals of Otorhinolaryngology, Head and Neck Diseases

2017

DOI: 10.1016/j.anorl.2016.07.010

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Sclerosing mucoepidermoid carcinoma of the sublingual gland

D.H. Lee

J.H. Kim

J.K. Lee

et al.

Abstract: Clinicians should consider sclerosing mucoepidermoid carcinoma in the differential diagnosis of salivary gland neoplasm. Surgical excision with clear margins seems to be a sufficient initial treatment option for sclerosing mucoepidermoid carcinoma of the salivary gland.

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Cited by 4 publications

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Sclerosing mucoepidermoid carcinoma of salivary glands

Othman,

Bradová,

Simpson

et al. 2024

Virchows Arch

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Sclerosing mucoepidermoid carcinoma (SMEC) of the salivary glands is a rare variant of low-grade mucoepidermoid carcinoma with scanty cellular atypia characterized by marked fibrosis/sclerosis and a rich inflammatory infiltrate. Herein, we report 25 unpublished cases of SMEC, two of them with prominent eosinophilia (2/25; 8%) and three with abundant IgG4-positive plasma cells (3/25; 12%). In our series of salivary SMEC, molecular analysis using fluorescence in situ hybridization (FISH) and/or next-generation sequencing (NGS) provided evidence of MAML2 gene rearrangement in 18 cases of the 21 analyzable cases tested (86%), while this gene locus was intact in 3 cases (14%). This study focuses on the diagnostic criteria of salivary SMEC given its challenge of abundant collagenous stroma, minimal residual neoplastic areas, and inconspicuous mucous cells. Follow-up data of our cases indicate that salivary SMECs have favorable outcomes. Molecular analysis for MAML2 gene rearrangement suggests that SMECs of salivary glands represent a rare variant of conventional low-grade MECs of salivary glands. In contrast, SMECs of the thyroid gland are genetically distinct from salivary-type thyroid MECs.

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Sclerosing mucoepidermoid carcinoma of salivary glands

Othman,

Bradová,

Simpson

et al. 2024

Virchows Arch

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Sublingual Gland Tumors Worldwide: A Descriptive Retrospective Study of 839 Cases

Lin

Wang

Zhang

et al. 2020

Journal of Oral and Maxillofacial Surgery

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MAML2-rearrranged sclerosing mucoepidermoid carcinoma of submandibular gland: an incidental finding in a patient with history of recurrent sialadenitis and Sjögren's syndrome

Hasan,

Duong,

Coblens

et al. 2024

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Sclerosing mucoepidermoid carcinoma of the sublingual gland

Abstract: Clinicians should consider sclerosing mucoepidermoid carcinoma in the differential diagnosis of salivary gland neoplasm. Surgical excision with clear margins seems to be a sufficient initial treatment option for sclerosing mucoepidermoid carcinoma of the salivary gland.

Cited by 4 publications

References 7 publications

Sclerosing mucoepidermoid carcinoma of salivary glands

Sclerosing mucoepidermoid carcinoma of salivary glands

Sublingual Gland Tumors Worldwide: A Descriptive Retrospective Study of 839 Cases

MAML2-rearrranged sclerosing mucoepidermoid carcinoma of submandibular gland: an incidental finding in a patient with history of recurrent sialadenitis and Sjögren's syndrome

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