Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Salivary Glands

Urano, Makoto; Abe, Masato; Horibe, Yoshimune; Kuroda, Makoto; Mizoguchi, Yoshikazu; Sakurai, Kazuo; Naito, Kensei

doi:10.1078/0344-0338-00259

Cited by 38 publications

(35 citation statements)

References 16 publications

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“…(i) Tumor infarction and (ii) host tissue reaction eventuating due to extravasated mucin pools. [789] Very often this pronounced desmoplasia in the salivary gland malignancy may be interpreted as an exaggerated mucous escape reaction. [5] Morphologic evidence in support of the mucin extravasation hypothesis is present in this case, as small pools of mucin were identified throughout the tumor.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing mucoepidermoid carcinoma of minor salivary gland

et al. 2014

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Sclerosing mucoepidermoid carcinoma (SMEC) is extremely rare variant of the mucoepidermoid carcinoma, which is the most common primary malignancy of the salivary glands. As its name suggests, SMEC is characterized by an intense central sclerosis that occupies the entirety of an otherwise typical tumor, frequently with an inflammatory infiltrate of plasma cells, eosinophils, and/or lymphocytes at its peripheral regions, but its uncompanionship with inflammatory cell infiltration might explain its progressive stage of the sclerosis. The sclerosis associated with these tumors may obscure their typical morphologic features and result in diagnostic difficulties. Tumor infarction and extravasation of mucin eventuating in reactive fibrosis are two mechanisms of formation that have been suggested as underlying this morphologic variant. Morphologic evidence in support of the mucin extravasation hypothesis was identified, as small pools of mucin were present throughout the tumor.

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Section: Discussionmentioning

confidence: 99%

Sclerosing mucoepidermoid carcinoma of minor salivary gland

et al. 2014

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“…They termed it as 'sclerosing mucoepidermoid carcinoma with eosinophilia'. They also suggested that SMEC in which eosinophilic infiltrate is more prominent is associated with good prognosis and eosinophils cause sclerosis [7]. Ide et al, reported the recurrence of a case of SMEC after 13 years of surgical excision which showed solid [6].…”

Section: Discussionmentioning

confidence: 99%

“…Urano et al, examined two cases of SMEC for MIB-1 marker to predict the clinical outcome. They found that MIB-1 staining was higher for the patient who died following the metastasis (7.2%) than in the patient who survived (4.5%) [7]. Veras …”

Section: Discussionmentioning

confidence: 99%

“…Fineneedle aspiration biopsies have failed to yield the diagnosIs of SMEC; and were reported as pathology of unknown type to benign tumour or nondiagnostic [5][6][7]. This can be due to sclerotic stroma surrounding the neoplastic cells which can be interpreted nondiagnostic [11].…”

Section: Discussionmentioning

confidence: 99%

“…But it may be focally positive in few cases. Immunohistochemically, tumour cells and duct like structures show positivity for cytokeratin and CEA (Urano et al, [7] and Kim H et al, [9]. Urano et al, examined two cases of SMEC for MIB-1 marker to predict the clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

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