Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: Case report of a rare lesion with novel genetic mutation

Abstract

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare primary cancer of the thyroid. This tumor is analogous to other primary tumors of the salivary glands, breast, pancreas, and esophagus. We present a case of this rare tumor with characteristic clinical features, ultrasound images, cytopathology, histopathology, and a heretofore undocumented somatic gene mutation. Additionally, we provide a succinct review of the controversial literature for this uncommon lesion.

The cytological features of sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: A case report

“…Reports on the cytological features of SMECE are very limited. [3][4][5][6][7] The FNAC findings of previous cases are summarised in Table 1…”

“…Primary SMECE of the thyroid is an extremely rare malignant neoplasm. Reports on the cytological features of SMECE are very limited 3‐7 . The FNAC findings of previous cases are summarised in Table 1.…”

“…2 Cytological descriptions of SMECE are scant and only five case reports (six cases) with cytological findings from aspiration specimens have been described. [3][4][5][6][7] Because of the rarity of SMECE, no definitive cytological criteria have been established.…”

Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers

“…BRAF V600E mutation was detected in two cases [110], and an APC gene variant of uncertain significance was also found in another case of SMECE [111]. Compared with conventional mucoepidermoid carcinomas, SMECEs are associated with more aggressive tumor biology.…”

Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features

“…Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) was first described as a distinct entity from mucoepidermoid carcinoma (MEC) in 1991 by Chan et al 1 Since that description, approximately 56 cases of SMECE have been reported with descriptions of histology 2 . Despite most thyroid nodules having been initially evaluated by fine‐needle aspiration (FNA), there are only 11 cases with descriptions of cytomorphology 3‐13 . No descriptions of SMECE have included concurrent salivary gland neoplasms.…”