Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

Lim, Daniel V.; Tan, Chuey Chuan; Tilakaratne, Wanninayake Mudiyanselage; Goh, Yet Ching

doi:10.1016/j.bjorl.2021.01.007

Cited by 13 publications

(18 citation statements)

References 26 publications

(23 reference statements)

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“…In relation to other odontogenic malignancies, a new entity of Sclerosing Odontogenic Carcinoma was added to the WHO Classification of Head and Neck Tumors (2017). There have been 14 cases published to date [ 46 ]. Features such as perineural invasion were cited to support its recognition as a malignant tumour, however it has a low mitotic activity and no metastases have been reported to date [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

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Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

Marín

Dave

Hunter

2021

Front. Oral. Health

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Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surgery due to their infiltrative nature and risk of metastasis. There is a need to understand the clinical and pathological features of MOTs to inform both treatment algorithms and prognostication. This is an area of diagnostic pathology which presents substantial difficulties in diagnosis, compounded by inconsistent use of terminology. Thus, this systematic review aimed to describe the clinical and pathological features of MOTs with a view to consolidating the literature and defining problematic areas in diagnosis and classification.Methods: An electronic database search was conducted in Web of Science, PubMed/Medline, and Embase. Additionally, the grey literature and reference lists of selected papers searched for completeness. Nine hundred and sixty articles were initially identified. Following removal of duplicates and application of inclusion/exclusion criteria, 312 articles were included for qualitative analysis.Results: The 312 articles encompassed a total of 507 patients with most lesions located within the mandible (74.3%). The most common first histological diagnosis was ameloblastic carcinoma (25.7% of all diagnoses), but there is considerable variation in how and when various diagnostic terms are used, and several misdiagnoses were reported. An initial benign diagnosis was made in 24.7% of patients, followed by a later malignant diagnosis and in this sub-group, the most common benign first diagnosis was ameloblastoma (42.4%). Cervical lymph nodes were the most common site of metastasis (9.3% of patients). With respect to distant metastasis (DM), the lungs were the most common organ affected (11.2% of DM patients) with metastasising ameloblastoma the most commonly reported tumour which metastasised to the lungs. Overall, 26.8% of patients developed recurrence.Conclusion: Overall, the quality of the literature on MOTs is poor. This review of the literature has highlighted variations in diagnostic terms and criteria which has resulted in areas of confusion with potential for misdiagnosis. This consolidation of primary data has identified key areas for targeted research including further discussion on the malignant potential of ameloblastoma.

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Section: Discussionmentioning

confidence: 99%

“…There have been 14 cases published to date [ 46 ]. Features such as perineural invasion were cited to support its recognition as a malignant tumour, however it has a low mitotic activity and no metastases have been reported to date [ 46 ]. Indeed, the diagnostic criteria for this entity are still somewhat vague.…”

Section: Discussionmentioning

confidence: 99%

Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

Marín

Dave

Hunter

2021

Front. Oral. Health

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“…The median age of the patients in this review was 54.4 years (range 31–73 years) and there was an 8:6 female predominance. Nine tumours involved the mandible and five the maxilla, most of them presenting with jaw enlargement, pain or other neurological signs and teeth mobility 4 . Radiographical examination in most cases disclosed an osteolytic process, localized or diffuse, with indiscrete borders and destruction of the cortical bone 4 …”

Section: Introductionmentioning

confidence: 99%

“…A recent review of the literature tabulated 14 cases, 4 whilst some additional cases may have been reported as central odontogenic fibromas (COdFs) or odontogenic carcinomas 5 …”

Section: Introductionmentioning

confidence: 99%

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A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

et al. 2022

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Aim To present a maxillary tumour showing features of sclerosing odontogenic carcinoma (SOC), i.e. bland cytology, partly sclerotic stroma and neural involvement, and contemplate whether its diagnostic feature, neural involvement, could represent epithelial neurotropism in a central odontogenic fibroma (COdF). Materials and methods A 58‐year‐old male presented with a depression on the palatal side of the alveolar ridge, extending from the right canine to the right first molar tooth. A CBCT of the maxilla revealed a multilocular radiolucency, with ill‐defined borders, causing destruction of the buccal and palatal cortical bone. Results Complete removal of the tumour was performed under general anaesthesia. Healing was uneventful and there was no evidence of recurrence in the 36 months clinical and radiographical follow up. The final diagnosis was an odontogenic tumour with bland cytology, sclerosis and neural involvement, consistent with SOC. Conclusions The tumour presented herein showed clinical, radiographical and microscopical features consistent with SOC and COdF, with neural involvement favouring a diagnosis of SOC. Epithelial neurotropism in a COdF could account for the similarities between those lesions and the rather quiescent, for an infiltrative intraosseous carcinoma, clinical behaviour of SOC.

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Central odontogenic fibroma with amyloid: a diagnostically challenging case

Ito¹,

Sakamoto²,

Obayashi³

et al. 2023

International Journal of Oral and Maxillofacial Surgery

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Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

Cited by 13 publications

References 26 publications

Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

Central odontogenic fibroma with amyloid: a diagnostically challenging case

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