Sclerosing Stromal Tumors, Thecomas, and Fibromas of the Ovary

Tiltman, A. J.; Haffajee, Zenobia

doi:10.1097/00004347-199907000-00011

Cited by 47 publications

(29 citation statements)

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“…Tiltman and Haffajee (9) concluded that SST and thecoma share many antigenic determinants and morphologic features and, thus, are probably closely related entities. In addition to the positivity for inhibin, calretinin, and a-glutathione-S-transferase, an enzyme associated with steroidogenesis in the ovary, these include the presence of myoid markers, both a-SMA and muscle-specific actin, and in most cases, absence of staining for desmin.…”

Section: Discussionmentioning

confidence: 99%

“…Most significantly, by immunohistochemistry these 3 types of neoplasm are positive for a-SMA and usually negative for desmin. At the conclusion of their study, they interpreted the calcified cases as a late stage of SST, but considered 459 THE PATHOGENESIS OF SCLEROSING STROMAL TUMOR the noncalcified tumor to have features that were only suggestive of SST; they regarded the diagnosis to be unconfirmed because the noncalcified case had a lower vascular density than the calcified cases (9). Later, Za´mecˇnı´k (30) reported a calcifying sclerosing tumor of the ovary in a 23-yr-old-women that was considered to be a late stage of SST.…”

Section: The Pathogenesis Of Sclerosing Stromal Tumormentioning

confidence: 99%

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On the Pathogenesis of Sclerosing Stromal Tumor of the Ovary

Roth

Gaba

Cheng³

2014

International Journal of Gynecological Pathology

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Sclerosing stromal tumor (SST) is a distinctive benign ovarian stromal neoplasm first reported in 1973. Although its initial description supports its characterization as an ovarian stromal tumor, its exact pathogenesis remains uncertain. It is usually hormonally inactive, but occasional tumors are estrogenic or androgenic, and virilization can occur during pregnancy. We report 11 cases of SST, 6 of which were associated with another type or other types of ovarian stromal tumor. In 4 of these, a transition from thecoma of either typical or luteinized type to SST was observed. Our index case was that of a 16-yr-old girl who had a typical thecoma that underwent involutional changes in an extensive subserosal portion of the tumor with conversion to SST. In our series, 3 cases of SST underwent transformation to ovarian myxoma, one of which also contained a component of thecoma. The active SST components stained for inhibin, steroidogenic factor 1, and α-smooth muscle actin, but were negative or occasionally weakly positive for desmin.

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Section: Discussionmentioning

confidence: 99%

Section: The Pathogenesis Of Sclerosing Stromal Tumormentioning

confidence: 99%

On the Pathogenesis of Sclerosing Stromal Tumor of the Ovary

Roth

Gaba

Cheng³

2014

International Journal of Gynecological Pathology

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“…However sclerosing stromal tumors have now been proposed to be derived from a population of muscle-specific actin-positive elements from the theca externa, namely, the perifollicular myoid stromal cells [9]. Tiltman and Haffajee [12] suggested that sclerosing stromal tumors and thecomas are probably closely related entities as they share some morphologic features and antigenic determinants like smooth muscle actin and vimentin.…”

Section: Discussionmentioning

confidence: 99%

“…CD34 positivity of sclerosing stromal tumors clearly distinguishes it from thecoma and fibroma. Vascular tumors are included in differential diagnosis due to prominent vascularity, but inhibin positivity suggests the diagnosis of sclerosing stromal tumor [9,12]. Sometimes massive edema of ovary may be confused with sclerosing stromal tumors.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing stromal tumor of the ovary

et al. 2014

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Sclerosing stromal tumor is a rare ovarian tumor, occurring in young adults in the second and third decade of life. We report clinical and histopathological features of three cases of sclerosing stromal tumor of the ovary with a review of literature. The tumor has distinct histological features and is easily recognizable when a high index of suspicion is maintained in young patients presenting with an ovarian mass. These tumors are benign and can be treated successfully by enucleation or unilateral ovariotomy.

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“…14 -16 Calretinin is positive in a higher proportion of fibromas and fibrothecomas than ␣-inhibin, making it a more sensitive, if less specific, marker of sex cord-stromal tumors. 15,[17][18][19] is also expressed in the majority of stromal tumors. 17…”

Section: Immunohistochemistrymentioning

confidence: 99%

Ovarian Stromal Tumors

Ioffe¹

2006

Pathology Case Reviews

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Ovarian stromal tumors range from fibroma to thecoma, depending on the degree of luteinization of tumor cells. They occur in peri-and postmenopausal women and are most commonly unilateral. The mitotic rate is the main feature helping predict the behavior of these tumors: while usual fibromas and thecomas are virtually amitotic, mitotic rate of 4 or more mitotic figures per 10 high-power fields is used as a cutoff to diagnose a fibrosarcoma. Fibrosarcomas, in addition to an increased mitotic rate, are also hypercellular and exhibit significant cytologic atypia; some may show tumor cell necrosis and could be adherent to adjacent pelvic organs, causing difficulty at surgery. Fibrosarcomas pursue a malignant clinical course, with local recurrence and metastases, usually to the lungs. Tumors with increased cellularity and mitotic counts of 3 or fewer mitoses per 10 high-power fields are termed cellular fibromas and have a somewhat increased likelihood of local recurrence after a long period of time, especially if they were adherent to pelvic organs or were ruptured at surgery. Ovarian stromal tumors may present a diagnostic difficulty when they undergo torsion with infarction and cystic change, which may render their histologic recognition problematic. Thorough sampling, along with immunohistochemistry for ␣-inhibin and calretinin, may help in making the correct diagnosis. Fibromas may be associated with several clinical and genetic syndromes, most notably Meigs syndrome, consisting of ascites and pleural effusions which resolve after tumor removal, and a hereditary Gorlin syndrome, consisting of multiple basal cell carcinomas, cysts of the jaw, and other neoplasms, including ovarian fibromas.

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Sclerosing Stromal Tumors, Thecomas, and Fibromas of the Ovary

Cited by 47 publications

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On the Pathogenesis of Sclerosing Stromal Tumor of the Ovary

On the Pathogenesis of Sclerosing Stromal Tumor of the Ovary

Sclerosing stromal tumor of the ovary

Ovarian Stromal Tumors

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