Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: An open clinical trial with 30 lesions

Johann, Aline Cristina Batista Rodrigues; Aguiar, Maria Cássia Ferreira de; Carmo, María Auxiliadora Vieira do; Gomez, Ricardo Santiago; Castro, Wagner Henriques; Mesquita, Ricardo Alves

doi:10.1016/j.tripleo.2004.12.021

Cited by 66 publications

(79 citation statements)

References 30 publications

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“…Treatment may involve one or more applications, depending on the extent of the lesion and on the results, which should be evaluated when the next dose is administered, after an interval of 1 to 2 weeks. 6,11,13 Sclerotherapy is contraindicated in uncontrolled diabetic patients and in areas of secondary infection. Administration of monoethanolamine oleate is contraindicated in expectant mothers, because it can have teratogenic effects.…”

Section: Discussionmentioning

confidence: 99%

Treatment of oral hemangioma with sclerotherapy: case report

et al. 2014

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Hemangiomas are benign neoplasms that are common in the head and neck, but relatively rare in the oral cavity. They can cause esthetic and functional impairment, depending on location. The most common site is the upper lip, but they can occur in other areas, such as the tongue, buccal mucosa and palate. Treatment is primarily dependent on correct diagnosis of the lesion and on its anatomic location. The purpose of this article is to provide a description of a case of a hemangioma on the upper lip, treated by therapeutic sclerosis with monoethanolamine oleate (Ethamolin  ), covering clinical characteristics and methods for diagnosing these lesions. Precise diagnosis and appropriate therapeutic management resulted in satisfactory esthetic and functional results, with total regression of the lesion and no signs of relapse at 1-year follow-up.Keywords: hemangioma; sclerotherapy; neoplasms, vascular tissue; mouth; lip. ResumoO hemangioma é uma neoplasia benigna comum na região de cabeça e pescoço, e é relativamente rara na cavidade oral, podendo causar prejuízo estético e funcional a depender da sua localização. Sua localização mais frequente é o lábio superior, mas pode ocorrer em outras regiões, como língua, mucosa jugal e palato. O seu tratamento depende, principalmente, do correto diagnostico da lesão, bem como da localização anatômica da mesma. A proposta deste artigo é relatar um caso de hemangioma em lábio superior tratado com esclerose terapêutica com oleato de monoetanolamina (Ethamolin  ), considerando as características clínicas e os métodos de diagnóstico desta lesão. Por

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Section: Discussionmentioning

confidence: 99%

Treatment of oral hemangioma with sclerotherapy: case report

et al. 2014

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“…There are many treatment modalities reported in the literature for oral hemangiomas, such as intralesional and systemic corticosteroid treatment, surgical excision, thermocauterization, laser photocoagulation, and sclerotherapy [4, 12–14]. Each of the treatment modalities has its own risks and advantages.…”

Section: Discussionmentioning

confidence: 99%

“…Most importantly, it has shown high efficacy, offering partial or complete regression of the lesion without bleeding [4, 15–18]. Disadvantages of sclerotherapy include postoperative pain and burning sensation, potential anaphylactic reaction, tissue necrosis, and airway compromise [19].…”

Section: Discussionmentioning

confidence: 99%

“…Usually hemangiomas present as blood-filled asymptomatic swellings or red/bluish-purple discolorations, but their progressive growth can increase the likelihood of local traumatic injuries followed by unexpected bleeding [4–7]. The size of hemangiomas is variable, ranging from a few millimeters to several centimeters in the form of a macule, papule, nodule, or tumor, with elastic or fibrous consistency [8].…”

Section: Introductionmentioning

confidence: 99%

“…However, complications that arise from conventional invasive surgical procedures such as excessive postoperative bleeding compelled the use of other different therapeutic alternatives including systemic corticosteroids, laser therapy, cauterization, cryotherapy, radiotherapy, and sclerotherapy [4, 12–14]. These modes of treatment can be applied individually or in concert.…”

Section: Introductionmentioning

confidence: 99%

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Sclerotherapy of Intraoral Superficial Hemangioma

Abdyli

Perjuci

et al. 2016

Case Reports in Dentistry

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Hemangioma is the clinical term for a benign vascular neoplasm due to proliferation of the endothelial lining of blood vessels. Their most frequent location is the body skin and oral mucosa. One of the treatment modalities for hemangiomas is intralesional injection of sclerosing agents which cause the damage of blood vessels followed by their obliteration. The objective of the study was to describe the facility of application and evaluate the efficiency of sclerotherapy with aethoxysklerol 1%. Method. The case presented with intraoral submucosal hemangioma of the cheek was treated by intralesional injection of aethoxysklerol 3% diluted in water for injections at a 4 : 1 ratio (0.75%) at the first appointment and 3 : 1 (1%) at the second appointment. The effect of sclerotherapy was evaluated on the following visits in time intervals of two weeks. Results. The hemangioma disappeared without complications after the second injection of aethoxysklerol 1%. The successful results of the study were comparable to the data of literature with variations according to the used sclerosant agent, its concentration, the number of injections, and the intervals between each session. Conclusion. Since sclerotherapy is a very effective, inexpensive, and easy-to-apply treatment, it should be the treatment of choice, especially for intraoral superficial hemangiomas.

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Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

Aparaschivei

Şunel

Popa

et al. 2014

Journal of Heterocyclic Chem

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New compounds with biological activity based on hydroxy‐amino derivatives of benzoxazolyl‐2‐mercaptoformic acid, benzoxazolyl‐2‐mercaptoacetic acid, and chloracetyl‐2‐mercaptobenzoxazole have been synthesized. The chemical bonding of these compounds to poly(maleic anhydride‐alt‐vinyl acetate), through esterification, leads in obtaining conjugates of polymer biologically active compound type, tests indicating a sustained release of the active chemical, with time (between 5 and 6 h). Reaction products were characterized through elemental and spectral analysis (FTIR and 1H NMR). Toxicology and antimicrobial activity tests recommend compounds with small molecule, as well as their conjugates as therapeutical candidates (antimicrobial inhibitors) for pharmacological application.

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Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: An open clinical trial with 30 lesions

Cited by 66 publications

References 30 publications

Treatment of oral hemangioma with sclerotherapy: case report

Treatment of oral hemangioma with sclerotherapy: case report

Sclerotherapy of Intraoral Superficial Hemangioma

Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

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