Sclerotic effect of bleomycin on the submandibular gland: An experimental model

Effect of Bone Marrow Derived Mesenchymal Stem Cells on Albino Rats, Submandibular Salivary Gland After Intraglandular Injection of Bleomycin

“…Bleomycin may be injected in salivary gland accidentally or intentionally when the glands are involved within the lesions. It is observed that intraglandular injection of bleomycin leads to apoptosis, inflammation, fibrosis, edema, lipomatosis and congestion in the ductal and acinar cells of submandibular salivary gland (9) . Muscarinic agonist medications are traditionally used for stimulation of saliva secretion from the remnant functional parts of the gland.…”