SCO-spondin, a glycoprotein of the subcommissural organ/reissner's fiber complex: Evidence of a potent activity on neuronal development in primary cell cultures

Meiniel, Annie

doi:10.1002/1097-0029(20010301)52:5<484::aid-jemt1034>3.0.co;2-0

Cited by 43 publications

(46 citation statements)

References 58 publications

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“…A role for SCO-spondin in the formation of the PC has been widely proposed (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005). This notion is supported by the following evidence: (i) SCO-spondin shares similarities with proteins involved in axonal guidance, (ii) this protein is expressed by the SCO before PC formation, (iii) SCO-spondin promotes neuritic outgrowth in vitro, and (iv) defective SCO differentiation correlates with impaired PC development.…”

Section: Discussionmentioning

confidence: 80%

“…Mutations in genes that regulate the development of prosomere 1, including Pax2/5, Pax6, and Msx-1 proteins, display a wide range of abnormalities in the development of the SCO that are highly similar to the phenotypes observed in the PC (Schwarz et al, 1999;Estivil-Torrus et al, 2001;Ferná ndez-LLebrez et al, 2004;Ramos et al, 2004). On the other hand, peptides containing the TSR motifs of SCO-spondin interfere with a variety of neuronal processes in vitro, including neuronal survival, neurite outgrowth, and fasciculation (Gobron et al, 1996(Gobron et al, , 2000Monnerie et al, 1998;Meiniel, 2001;Meiniel et al, 2003). Although these results suggest a role for the SCO and its secretory product, SCO-spondin, in the formation of the PC, the molecules and mechanisms that mediate this effect are poorly understood.…”

Section: Introductionmentioning

confidence: 90%

“…Even before the development of the PC, SCO cells synthesize a high molecular weight glycoprotein, named SCO-spondin. Because of the presence of several thrombospondin repeats (TSR), SCO-spondin belongs to the TSR superfamily of proteins (Gobron et al, 1996;Meiniel, 2001). This superfamily includes F-spondin, thrombospondin-1 and -2, mindin and semaphorin-5, proteins expressed during neural development that have been involved in a variety of biological processes, including axonal pathfinding and neural crest cell migration (Adams and Tucker, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…A functional relationship between the SCO and the development of the PC has been proposed (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005). Mutations in genes that regulate the development of prosomere 1, including Pax2/5, Pax6, and Msx-1 proteins, display a wide range of abnormalities in the development of the SCO that are highly similar to the phenotypes observed in the PC (Schwarz et al, 1999;Estivil-Torrus et al, 2001;Ferná ndez-LLebrez et al, 2004;Ramos et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In the few studies related to the basal secretion (Losecke et al, 1984(Losecke et al, , 1986Biosca and Azcoitia, 1989;Rodríguez et al, 1984a,b;Peruzzo et al, 1990), the authors performed studies in adult animals, and concluded that basal secretion of SCO-spondin was probably toward the blood vessels or toward the subarachnoidal space. Nonetheless, despite the fact that SCO-spondin has been suggested to play a role in PC development (Gobron et al, 2000;Meiniel, 2001;Ferná ndez-Llebrez et al, 2001;Lehmann and Naumann, 2005), there are no reports addressing the basal secretion of this protein toward the extracellular matrix that surrounds the axons of the PC at embryonic stages.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Caprile

Osorio

Henríquez

et al. 2009

Developmental Dynamics

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The roof plate of the caudal diencephalon is formed by the posterior commissure (PC) and the underlying secretory ependyma, the subcommissural organ (SCO). The SCO is composed by radial glial cells bearing processes that cross the PC and attach to the meningeal basement membrane. Since early development, the SCO synthesizes SCO-spondin, a glycoprotein that shares similarities to axonal guidance proteins. In vitro, SCO-spondin promotes neuritic outgrowth through a mechanism mediated by integrin ␤1. However, the secretion of SCO-spondin toward the extracellular matrix that surrounds the PC axons and the expression of integrins throughout PC development have not been addressed. Here we provide immunohistochemical evidence to suggest that during chick development SCO cells secrete SCO-spondin through their basal domain, where it is deposited into the extracellular matrix in close contact with axons of the PC that express integrin ␤1. Our results suggest that SCO-spondin has a role in the development of the PC through its interaction with integrin ␤1.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Caprile

Osorio

Henríquez

et al. 2009

Developmental Dynamics

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Otoc1: A novel otoconin‐90 ortholog required for otolith mineralization in zebrafish

Petko

Millimaki

Canfield

et al. 2007

Developmental Neurobiology

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Within the vestibular system of virtually all vertebrate species, gravity and linear acceleration are detected via coupling of calcified masses to the cilia of mechanosensory hair cells. The mammalian ear contains thousands of minute biomineralized particles called otoconia, whereas the inner ear of teleost fish contains three large ear stones called otoliths that serve a similar function. Otoconia and otoliths are composed of calcium carbonate crystals condensed on a core protein lattice. Otoconin-90 (Oc90) is the major matrix protein of mammalian and avian otoconia, while otolith matrix protein (OMP) is the most abundant matrix protein found in the otoliths of teleost fish. We have identified a novel gene, otoc1, which encodes the zebrafish ortholog of Oc90. Expression of otoc1 was detected in the ear between 15 hpf and 72 hpf, and was restricted primarily to the macula and the developing epithelial pillars of the semicircular canals. Expression of otoc1 was also detected in epiphysis, optic stalk, midbrain, diencephalon, flexural organ, and spinal cord. During embryogenesis, expression of otoc1 mRNA preceded the appearance of omp-1 transcripts. Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths.

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Msx1 disruption leads to diencephalon defects and hydrocephalus

Ramos¹,

Fernández-Llébrez²,

Bach³

et al. 2004

Developmental Dynamics

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We have analyzed the expression of the Msx1 gene in the developing mouse brain and examined the brain phenotype in homozygotes. Msx1 is expressed in every cerebral vesicle throughout development, particularly in neuroepithelia, such as those of the fimbria and the medulla. Timing analysis suggests that Msx1 nLacZ cells delaminate and migrate radially from these epithelia, mainly at embryonic days 14 -16, while immunohistochemistry studies reveal that some of the ␤-galactosidase migrating cells are oligodendrocytes or astrocytes. Our results suggest that the Msx1 neuroepithelia of fimbria and medulla may be a source of glial precursors. The Msx1 mutants display severe hydrocephalus at birth, while the subcommissural organ, the habenula, and the posterior commissure fail to develop correctly. No label was detected in the mutant subcommissural organ using a specific antibody against Reissner's fiber. Besides, the fasciculus retroflexus deviates close to the subcommissural organ, while the paraventricular thalamic nucleus shows histological disorganization. Our results implicate the Msx1 gene in the differentiation of the subcommissural organ cells and posterior commissure and that Msx1 protein may play a role in the pathfinding and bundling of the fasciculus retroflexus and in the structural arrangement of the paraventricular thalamic nucleus.

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SCO-spondin, a glycoprotein of the subcommissural organ/reissner's fiber complex: Evidence of a potent activity on neuronal development in primary cell cultures

Cited by 43 publications

References 58 publications

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin

Otoc1: A novel otoconin‐90 ortholog required for otolith mineralization in zebrafish

Msx1 disruption leads to diencephalon defects and hydrocephalus

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