Scolicidal Effects of Olea europaea and Satureja khuzestanica Extracts on Protoscolices of Hydatid Cysts

Zibaei, Mohammad; Sarlak, Amanallah; Delfan, Bahram; Ezatpour, Behrouz; Azargoon, Alireza

doi:10.3347/kjp.2012.50.1.53

Cited by 46 publications

(24 citation statements)

References 18 publications

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“…A total of 13 flavonoids (compounds 1 to 13) were isolated from this extract and identified as xanthomicrol (1) [26], acacetin (2) [19], as shown in Figure 1, by comparison of their spectral data ( 1 H-NMR, 13 C-NMR, EI-MS) with those reported in the literature. M A N U S C R I P T …”

Section: Resultsmentioning

confidence: 99%

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A new bioactive monoterpene–flavonoid from Satureja khuzistanica

et al. 2015

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Section: Resultsmentioning

confidence: 99%

“…Sub-fraction E 3 was a pure compound (11, 7 mg A C C E P T E D M A N U S C R I P T Table 3. 13 C NMR data of the compounds from S. khuzistanica in DMSO-d 6 . …”

Section: Accepted Manuscriptmentioning

confidence: 99%

A new bioactive monoterpene–flavonoid from Satureja khuzistanica

et al. 2015

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“…Protoscolicidal effect of 0.1% olive leaf extract was confirmed in prior studies. This effect is seen in prolonged exposure and as the extract contains numerous chemicals this effect can be attributed to various substances (10,13). Primary medical constituents contained in unprocessed olive leaf are oleuropein, hydroxytyrosols and many other flavonoids (10).…”

Section: Discussionmentioning

confidence: 99%

“…Waiting shorter periods puts the patient theoretically in a risk of secondary hydatidosis in case of a spillage if encountered during the surgery. With the isolated form of oleuropein instead of olive leaf extract, we chose shorter exposure times in contrast to a previous study (13). As stated before, these shorter exposure times are more convenient for surgical intervention, and if oleuropein was the agent responsible from protoscolicidal effect of olive leaf extract, using it as a pure substance may enhance its activity.…”

Section: Discussionmentioning

confidence: 99%

Protoscolicidal effect of oleuropein: an in vitro study

Arslan¹,

Özant²,

Özçay³

et al. 2019

Turk J Surg

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Objective: Hydatid disease is a parasitic disease caused by Echinococcus granulosus and is still endemic in many parts of the world. Scolicidal solutions are generally used in any type of intervention, either surgical or percutaneous, to neutralize the cyst contents, although completeness of their effect is obscure and solid evidence is scarce. On the other hand, the use of these scolicidal solutions is not devoid of complications and many serious complications such as caustic sclerosing cholangitis may be seen in relation with their usage. Recent investigations proved protoscolicidal properties of olive leaf extract although the active ingredient has not been attributed to any component. The aim of this experimental study was to isolate oleuropein and test for in vitro protoscolicidal activity. Material and Methods: Oleuropein, a phenolic compound found in olive leaves, is extracted and prepared in different concentrations. Echinococcal cyst containing livers of sheep are obtained from the government slaughterhouse. Cysts were punctured and live protoscolex suspensions were prepared under aseptic conditions. Different concentrations of oleuropein solutions were prepared and protoscolicidal property is analyzed and compared with positive and negative controls for different exposure times. Results: Oleuropein 2% concentration was found to be protoscolicidal in all exposure times starting from 5 minutes. Conclusion: 2% oleuropein is a powerful, natural protoscolicidal agent which should be evaluated clinically before its application in routine treatment practice.

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“…The suspension was filtered with a Whatman Filter Paper No.1. 22 The procedure of extraction was operated via rotary evaporation at 37°C and the extracts were stored at 4°C until use.…”

Section: Extracts Preparationmentioning

confidence: 99%

In Vitro Assessment of the Protoscolicidal Activities of the Ephedra major Methanol Extracts

Zibaei¹,

Sepideh²,

Zohreh³

et al. 2017

Int J Enteric Pathog

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Background: The basic approaches for the treatment of human hydatidosis are surgery and chemotherapy. The risk of spillage of protoscoleces cannot be underestimated during surgery. Objectives: This study aimed to evaluate the scolicidal activity of Ephedra major methanol extracts against protoscoleces of hydatid cysts. Materials and Methods: Various concentrations of the methanolic extracts (0.01%-0.001%, mg/mL) of different parts of E. major were used for exposure times of 10, 20, 30, and 60 minutes. Results: Different extracts of E. major were tested, 0.1% concentration had strong scolicidal activity in 60 minutes. The stem extracts of 0.1% had very strong scolicidal effects in 60 minutes of exposure time and the mortality rate decreased with the lower concentration. Conclusion: Findings showed that scolicidal effects of E. major root extracts against cystic echinococcosis protoscoleces were less effective, while the stem and leaf extracts demonstrated more activities, respectively.

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Scolicidal Effects of Olea europaea and Satureja khuzestanica Extracts on Protoscolices of Hydatid Cysts

Cited by 46 publications

References 18 publications

A new bioactive monoterpene–flavonoid from Satureja khuzistanica

A new bioactive monoterpene–flavonoid from Satureja khuzistanica

Protoscolicidal effect of oleuropein: an in vitro study

In Vitro Assessment of the Protoscolicidal Activities of the Ephedra major Methanol Extracts

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