2024
DOI: 10.3390/toxins16100446
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Scoliidines: Neuroprotective Peptides in Solitary Scoliid Wasp Venoms

Carlos Alberto-Silva,
Fernanda Calheta Vieira Portaro,
Roberto Tadashi Kodama
et al.

Abstract: A comprehensive LC-MS study examined the venom components of the solitary scoliid wasp Scolia oculata. Online mass fingerprinting showed that crude venom contains 25 small molecules (amino acids, biogenic amines, and nucleosides/nucleotides) and 45 peptides with MW 400-2700. The small molecules were identified by elemental composition analysis, and peptide sequences were determined by ESI-MS/MS and MALDI-TOF/TOF MS analyses. As major peptide components, a known peptide, β-scoliidine (DYVTVKGFSPLRKA), and three… Show more

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