Scoliosis in China

Qiu, Guixing

doi:10.4103/0366-6999.217081

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…Scoliosis is defined as a three-dimensional spinal deformity involving one or more spinal curves with lateral deviation and axial rotation of the vertebrae [1]. Standing coronal radiographs, including the entire spine and iliac crest, is an economical imaging evaluation modality for scoliosis [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a computer-aided method for measuring the Cobb angle on chest X-rays

Pan

Chen²,

Chen

et al. 2019

Eur Spine J

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Objectives To automatically measure the Cobb angle and diagnose scoliosis on chest X-rays, a computer-aided method was proposed and the reliability and accuracy were evaluated. Methods Two Mask R-CNN models as the core of a computer-aided method were used to separately detect and segment the spine and all vertebral bodies on chest X-rays, and the Cobb angle of the spinal curve was measured from the output of the Mask R-CNN models. To evaluate the reliability and accuracy of the computer-aided method, the Cobb angles on 248 chest X-rays from lung cancer screening were measured automatically using a computer-aided method, and two experienced radiologists used a manual method to separately measure Cobb angles on the aforementioned chest X-rays. Results For manual measurement of the Cobb angle on chest X-rays, the intraclass correlation coefficients (ICC) of intra-and inter-observer reliability analysis was 0.941 and 0.887, respectively, and the mean absolute differences were < 3.5°. The ICC between the computer-aided and manual methods for Cobb angle measurement was 0.854, and the mean absolute difference was 3.32°. These results indicated that the computer-aided method had good reliability for Cobb angle measurement on chest X-rays. Using the mean value of Cobb angles in manual measurements > 10° as a reference standard for scoliosis, the computer-aided method achieved a high level of sensitivity (89.59%) and a relatively low level of specificity (70.37%) for diagnosing scoliosis on chest X-rays. Conclusion The computer-aided method has potential for automatic Cobb angle measurement and scoliosis diagnosis on chest X-rays.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a computer-aided method for measuring the Cobb angle on chest X-rays

Pan

Chen²,

Chen

et al. 2019

Eur Spine J

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“…OSA is also significantly correlated with ASD risk in this study (P < 0.05). The prevalence of this comorbidity among PWS patients is higher than in the general population (40)(41)(42). We suggest that early diagnosis and treatment of sleep disorders among PWS patients could reduce their ALP and ASD expression and improve their overall prognosis.…”

Section: Discussionmentioning

confidence: 85%

Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome

et al. 2020

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Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height (P = 0.0186), overweight (P = 0.0248), and obstructive sleep apnea (P = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.

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“…Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that occurs during puberty in children aged 10 to 18 years, with an uncertain pathogenesis. The morbidity rate ranges from 1% to 4% in adolescence, as reported in the literature, and the female-to-male ratio varies from 1.5 to 11 [1–3] . Most cases of AIS progress until epiphyseal plate fusion.…”

Section: Introductionmentioning

confidence: 92%

“…Furthermore, the mRNA levels of C/EBPa, PPARg2, FABP4, and LPL were markedly increased in the AIS-related osteopenia group compared with those in the control group [Figure 2C and 2D and Supplementary Figure 3A and 3B, http://links.lww.com/CM9/B299]. The trend of adipogenic marker expression in the BMSCs was also assessed over time (3,7,10,14,17, and 21 days). In general, the mRNA and protein levels of markers in both the AIS and control groups increased in a time-dependent manner.…”

Section: Bmscs From Patients With Ais-related Osteopenia Have a Lower...mentioning

confidence: 99%

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Impaired autophagy activity-induced abnormal differentiation of bone marrow stem cells is related to adolescent idiopathic scoliosis osteopenia

Zhang

Yang

et al. 2022

Chinese Medical Journal

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Background: Osteopenia has been well documented in adolescent idiopathic scoliosis (AIS). Bone marrow stem cells (BMSCs) are a crucial regulator of bone homeostasis. Our previous study revealed a decreased osteogenic ability of BMSCs in AIS-related osteopenia, but the underlying mechanism of this phenomenon remains unclear. Methods: A total of 22 AIS patients and 18 age-matched controls were recruited for this study. Anthropometry and bone mass were measured in all participants. Bone marrow blood was collected for BMSC isolation and culture. Osteogenic and adipogenic induction were performed to observe the differences in the differentiation of BMSCs between the AIS-related osteopenia group and the control group. Furthermore, a total RNA was extracted from isolated BMSCs to perform RNA sequencing and subsequent analysis.Results: A lower osteogenic capacity and increased adipogenic capacity of BMSCs in AIS-related osteopenia were revealed. Differences in mRNA expression levels between the AIS-related osteopenia group and the control group were identified, including differences in the expression of LRRC17, DCLK1, PCDH7, TSPAN5, NHSL2, and CPT1B. Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed several biological processes involved in the regulation of autophagy and mitophagy. The Western blotting results of autophagy markers in BMSCs suggested impaired autophagic activity in BMSCs in the AIS-related osteopenia group. Conclusion: Our study revealed that BMSCs from AIS-related osteopenia patients have lower autophagic activity, which may be related to the lower osteogenic capacity and higher adipogenic capacity of BMSCs and consequently lead to the lower bone mass in AIS patients.

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Scoliosis in China

Cited by 12 publications

References 12 publications

Evaluation of a computer-aided method for measuring the Cobb angle on chest X-rays

Evaluation of a computer-aided method for measuring the Cobb angle on chest X-rays

Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome

Impaired autophagy activity-induced abnormal differentiation of bone marrow stem cells is related to adolescent idiopathic scoliosis osteopenia

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