Scoliosis Induced by Medullary Damage

Barrios, Clara García; Tuñón, M. T.; Salis, J. A. De

doi:10.1097/01241398-198801000-00052

Cited by 2 publications

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“…In knock-out mice with an inactivated gene (LbX1 -/ -), the morphology of neurons and neural circuits in the dorsal horns are aberrant, suggesting that the LBX1 protein is a critical factor for the development of sensory pathways in the spinal cord (Müller et al, 2002). Studies on dorsal rhizotomized animals show a higher incidence of scoliosis and assume the role of somatosensory dysfunction in the etiopathogenesis of scoliosis (Barrios et al, 1987;Suk et al, 1989). In clinical studies, it was found that growing children with functional or organic disorders of the somatosensory pathways are more prone to scoliosis compared with their peers (Kouwenhoven and Castelein, 2008).…”

Section: Discussionmentioning

confidence: 99%

Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population

Nikolova¹,

Dikova²,

Dikov³

et al. 2019

J Appl Biomed

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Idiopathic scoliosis (IS) is a common medical condition in children, characterized by three-dimensional spinal curve and strong evidence of genetic predisposition. The purpose of the present case-control study is to examine the association between the polymorphic variant rs11190870 (T/C), near the LBX1 gene, and IS predisposition in distinct subgroups based on age at onset, family history and gender. A total of 127 IS patients and 254 unrelated controls of Southeastern European descent were recruited. The genotyping was carried out by TaqMan real-time amplification technology. The results were analyzed by the Pearson's Chi-squared Test and the Fisher's Exact Test with a value of p less than 0.05 as statistically significant. The T allele and homozygous TT genotype were associated with a greater incidence of IS. Our results suggest that there is a genetic association with IS in adolescents, familial and non-familial cases, and in females. Larger case-control studies are necessary to examine the genetic factors of IS/AIS etiology in infants, juveniles and males. In conclusion, the molecular genetic identification of diagnostic and prognostic molecular markers would make an early treatment including minimally invasive procedures possible.

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Section: Discussionmentioning

confidence: 99%

Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population

Nikolova¹,

Dikova²,

Dikov³

et al. 2019

J Appl Biomed

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Ecology and Management of Hazelnut Pests

Aliniazee

1998

Annu. Rev. Entomol.

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Insect and mite pests cause serious damage to the hazelnut crop worldwide. The control strategies used against these pests include application of insecticides, classical and augmentative biological control, utilization of resistant varieties, and use of Bacillus thuringiensis-based preparations. In the United States, extensive research has been directed toward elucidating ecological interactions among different pests and natural enemies and understanding the role of abiotic factors in pest population dynamics. Differences exist worldwide regarding the understanding of pests and natural enemy biologies and, to a limited extent, control practices. An integrated pest management approach based on utilizing effective sampling and monitoring techniques and a near complete reliance on biological control and "soft" pesticides, including insect growth regulators, is currently under development both in North America and Europe/Turkey. Hazelnuts are on the verge of becoming one of the first crops in the United States that could possibly be produced commercially without the use of any broad-spectrum organic insecticides.

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Scoliosis Induced by Medullary Damage

Cited by 2 publications

References 0 publications

Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population

Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population

Ecology and Management of Hazelnut Pests

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