Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes

Noh, Jung‐Ran; Kim, Yong‐Hoon; Hwang, Jung Hwan; Gang, Gil-Tae; Yeo, Seung-Hoon; Kim, Kyoung‐Shim; Oh, Wook; Ly, Sun Yung; Lee, Inkyu; Lee, Chul‐Ho

doi:10.1016/j.foodchem.2013.04.036

Cited by 35 publications

(31 citation statements)

References 29 publications

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“…ACCEPTED MANUSCRIPT 18 Many polyphenols were reported to inhibit adipocyte differentiation through suppressing the key transcription factors involving in the maturation process of adipocytes such as PPARγ, C/EBPs and SREBPs [22,36]. In the current study, we found that A-type ECG dimer and A-type EGCG dimer exerted significant effects against 3T3-L1 adipocyte differentiation by suppressing mRNA levels of PPARγ, C/EBPα and SREBP1C as well as the mRNA levels of PPARγ target genes including HSL, LPL and aP2…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

Zhu

Zou

Nie

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Accepted Manuscriptmentioning

confidence: 99%

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

Zhu

Zou

Nie

et al. 2015

The Journal of Nutritional Biochemistry

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“…17 The mature adipocytes (day 8) were washed twice and collected in 1 ml of ice-cold PBS (0.1 mol L −1 , pH 7.4) using a cell scraper, and then sonicated (300 W, 15 min, repeated 3 times). 17 The mature adipocytes (day 8) were washed twice and collected in 1 ml of ice-cold PBS (0.1 mol L −1 , pH 7.4) using a cell scraper, and then sonicated (300 W, 15 min, repeated 3 times).…”

Section: Quantification Of Intracellular Triglyceride (Tg)mentioning

confidence: 99%

Suppressive effects of saponin-enriched extracts from quinoa on 3T3-L1 adipocyte differentiation

et al. 2015

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This study was performed to investigate the effect of quinoa saponins (QS) on the differentiation of 3T3-L1 preadipocytes. QS inhibited triglyceride (TG) accumulation in the mature adipocytes, evidenced by oil-red O staining and intracellular quantification. Real time-PCR analysis and western blot analysis showed that QS significantly down-regulated the mRNA and protein expression of key adipogenic transcription factors, peroxisome proliferator-activated receptor γ (PPARγ), and CCAAT/enhancer-binding protein alpha (C/EBPα), however, they had no significant effect on CCAAT/enhancer-binding protein beta (C/EBPβ) and CCAAT/enhancer-binding protein delta (C/EBPδ) which are the upstream regulators for adipogenesis compared with mature adipocytes. QS also reduced mRNA and protein expression of sterol regulatory element-binding protein-1c (SREBP-1c) related to the late stage of adipogenesis. Furthermore, lipoprotein lipase (LPL), adipocyte protein 2 (aP2) and glucose transporter 4 (Glut4), as adipocyte specific genes, were decreased in mature adipocytes by QS treatment. These findings indicate that QS are capable of suppressing adipogenesis and therefore they seem to be natural bioactive factors effective in adipose tissue mass modulation.

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“…For example, plant extracts including polyphenols, resveratrol, curcumin, and proanthocyanidins, have become increasingly popular in the past decades for their anti-adipogenic properties [1,13,14]. It was also reported that herbal medicine was effective as potential therapy for fatty liver disease, diabetes, and metabolic syndrome [15].…”

Section: Introductionmentioning

confidence: 99%

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Seo

Goo

Chung

et al. 2017

IJMS

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Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity.

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Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes

Cited by 35 publications

References 29 publications

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

A-type ECG and EGCG dimers disturb the structure of 3T3-L1 cell membrane and strongly inhibit its differentiation by targeting peroxisome proliferator-activated receptor γ with miR-27 involved mechanism

Suppressive effects of saponin-enriched extracts from quinoa on 3T3-L1 adipocyte differentiation

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

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