Scope of Nanotechnology in Drug Delivery

Maroof, Kashif; Zafar, Farya; Ali, Huma; Naveed, Safila; Tanwir, Sidra

doi:10.4172/jbb.1000257

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…And the second step involved preparation of paclitaxel Nanocochleate. I had prepared paclitaxel loaded Nanocochleates by trapping method (Webster, 2007;Maroof and Zafar, 2015).…”

Section: L3mentioning

confidence: 99%

Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy

S¹,

S²,

B³

et al. 2020

ijrps

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The nanocochleates are mainly prepared from the liposomes of active pharmaceutical ingredients (APIs) with the help of inactive ingredients like phosphatidylserine (PS) and calcium. The PS shows a considerable binding affinity towards calcium mainly due to the calcium’s tendency to lose part of its hydration shell and to displace water upon complexation. Due to neutralization of the electrostatic charge, calcium causes aggregation & fusion of liposomes composed PS with each other. It has been reported that ca++ has an affinity to form a more tightly packed & highly ordered and less hydrated structure than mg++ with phosphatidylserine, even at a much lower concentration. It is well documented that ca++ plays a vital role in natural membrane fusion phenomena while other cations are ineffective in most such systems. The stability of Nano-cochleate can be increased by doing freeze-drying of finished product which in turn provides a longer shelf life to the product at, where solution form is most unstable. Based on various literature survey and laboratory work, ‘The Ethanol Injection Method’ was selected for the preparation of Nanoliposomes followed by Nanocochleates. For this study; Paclitaxel was selected as an Active Pharmaceutical Ingredient (API) to formulate Phospholipid based Nanocochleate. The developed Nanocochleates exhibited higher encapsulation efficiency and controlled release of Paclitaxel. This technology may bring about a reduction in dose as well as cost and increase patient compliance. These Nanocochleates could therefore advantageously be employed to improve anticancer activity of Paclitaxel and an alternative to present intravenous administration. From the present study, it can be concluded that the developed Nanocochleates exhibited higher encapsulation efficiency and controlled release of Paclitaxel which may prove to be a suitable & potential candidate for healing a Cancer at a lower concentration.

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“…And the second step involved preparation of paclitaxel Nanocochleate. I had prepared paclitaxel loaded Nanocochleates by trapping method (Webster, 2007;Maroof and Zafar, 2015).…”

Section: L3mentioning

confidence: 99%

Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy

S¹,

S²,

B³

et al. 2020

ijrps

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“…Nanomedicine has been placing ahead several therapeutic principles that disrupt the manner we had been dealing with most cancers therapy, i.e. nanoparticles as drug shipping dealers, minimising side consequences and toxicity of the medicine [53] .…”

Section: In Drug Deliverymentioning

confidence: 99%

Nanotechnology - A Path to a Sustainable Future

Goyal¹,

Ghildiyal²

2016

Res. Rev. J Mat. Sci

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Nanotechnology is a varied area of technology which offers with floor technology, organic chemistry, molecular biology, semiconductor physics and micro-fabrication and so on. It's far the usage of era on the nano (10-9) degree. A fundamental definition of nanotechnology is the examine manipulation and manufacture of highly minute machines or devices. The related studies and applications are similarly diverse, ranging from extension of conventional physics to completely new techniques primarily based upon developing new substances with new dimensions on nanoscale. Scientists presently debate the destiny implications of nanotechnology. Nanotechnology can be capable of create many new substances and gadgets with a great variety of applications, which embody medication, electronics, biomaterials and so on. From the contemporary overview paper we are able to finish that nanomaterial's is located to have massive applications in diverse fields which have been described inside the paper. So, we can finish that Nanotechnology performs a prime position in nowadays studies paintings.

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“…The utilization of particles in an extremely minute range helps to promote the properties and whole quality of the system. Particles existing in nanotechnology shows better attributes including, improved quality with a lower weight, protection from settling and decomposition, elevated saturation solubility state, enhanced drug absorption and release, increased adhesion to biological membranes, improved chemical reactivity, effective therapeutic action, improved bioavailability, and also decreasing side effects (Maroof et al, 2016; Sousa et al, 2019; Sultana et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic nanostructures and nanotoxicity

Sarma¹,

Bania²,

Devi³

et al. 2021

J of Applied Toxicology

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Nanotechnology, with its continuous advancement, leads to the development of nanoscale‐level therapeutics to mitigate many complex diseases. This results in the emergence of numerous novel nanomaterials and its composite products into the market such as liposome, polymeric nanoparticles, dendrimers, and nanostructured lipid carrier. However, their application is always determined by a high benefit to risk ratio. Very few research have been done on the toxicity assessment of nanoparticles in the biological system; therefore, the limited knowledge regarding the toxicity profile of nanotherapeutics is available leading to the ignorance of its side effects. Nanoparticles can distribute in the whole body through translocating in the bloodstream by crossing membrane barriers efficiently and shows effect in organs and tissues at cellular and molecular levels. The interaction of nanoparticle with cell may consequences into nanotoxicity. The narrow size distribution, large surface area to mass ratio and surface properties of nanoparticle are significantly associated with nanotoxicity. Nanoparticles can enter into the tissue and cell by invading the membranes and cause cellular injury as well as toxicity. Therefore, the exploration of mechanisms of nanotoxicity has prime importance now a day. The toxicity assessment should be an integral part of the development of nanotherapeutics using various toxicity evaluation models. This review has focused on the exploration of different nanostructures for therapeutic delivery system along with its physicochemical characteristics responsible for adverse effects on human biology, various toxicity evaluation models, and environmental and regulatory hurdles.

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Scope of Nanotechnology in Drug Delivery

Cited by 7 publications

References 46 publications

Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy

Formulation and Evaluation of Lyophilized Nanocochleates of Paclitaxel – For Cancer Chemotherapy

Nanotechnology - A Path to a Sustainable Future

Therapeutic nanostructures and nanotoxicity

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