Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies

Abstract

The advent of the clinically approved drug cisplatin started a new era in the design of metallodrugs for cancer chemotherapy.

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

“…This opened the door for the development of a myriad of organometallic complexes bearing the half-sandwich ruthenium(II)-arene scaffold [ 53 , 54 ]. Among those, symmetric and mixed cationic trithiolato-bridged dinuclear ruthenium(II)-arene compounds of general formula [( η 6 - p -MeC 6 H 4 Pr i ) 2 Ru 2 ( µ 2 -SR) 3 ] + [ 55 , 56 ] and, respectively, [( η 6 - p -MeC 6 H 4 Pr i ) 2 Ru 2 ( µ 2 -SR 1 )( µ 2 -SR 2 ) 2 ] + [ 57 ] ( Figure 1 ) have shown high cytotoxicity against human cancer cells (IC 50 values as low as 30 nM against A2780 human ovarian cancer cells and the cisplatin-resistant variant A2780cisR) [ 58 ].…”

Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells

“…In the realm of bio‐organometallic chemistry, the ferrocifen system continues to attract significant attention . These molecules possess a ferrocenyl‐ene‐ p ‐phenol motif, and a basic dimethylaminoalkoxy chain, as in 3 .…”

Microwave assisted synthesis of disubstituted benzyltin arylformylhydrazone complexes: anticancer activity and DNA‐binding properties

“…This compound inspired the development of subsequent small molecule metal complexes as anticancer drugs. Because of this breakthrough, researchers have considered whether other metal complexes have anticancer effects . In 1972, Brown found that Ph 3 SnOOCCH 3 can inhibit the growth of mouse tumors, and scientists have reported the in vitro anticancer activity of organotin compounds .…”

“…Because of this breakthrough, researchers have considered whether other metal complexes have anticancer effects. [2][3][4][5][6][7] In 1972, Brown [8] found that Ph 3 SnOOCCH 3 can inhibit the growth of mouse tumors, and scientists have reported the in vitro anticancer activity of organotin compounds. [9][10][11][12][13] After extensive research, organotin complexes are considered a promising class of anticancer drug.…”