Kazakhstan is in Central Asia and is the ninth-largest country in the world. Some socially vulnerable segments of the Kazakh population residing in subsidised social housing have experienced a range of problems due to the low quality of housing construction and its planning. Poor indoor environmental conditions in social housing contribute to occupants’ comfort, health, and general well-being. This study assessed social housing residents’ health and quality of life, focusing on their perceived indoor air quality and thermal comfort satisfaction. A cross-sectional survey in Kazakhstan was conducted to test the effects of environmental factors on social housing residents’ health and satisfaction. Four hundred thirty-one responses were analysed, and the SF12v2 questionnaire was used to measure the health-related quality of life. Multiple regression analysis showed that air quality negatively predicted the respondents’ physical (PCS) and mental (MCS) health. In addition, age, smoking, and employment status had a significantly negative effect on PCS, while education level had a predictive positive effect. Thermal conditions negatively predicted only MCS, as well as alcohol consumption. Next, the air-conditioning control factor had a negative effect. In contrast, low air circulation, low humidity, high solar gain, temperature imbalance, duration of the residence and alcohol consumption had a significantly positive effect on overall satisfaction with the temperature. The odour sources from tobacco, furniture and external sources were predictors of respondents’ overall air quality satisfaction, along with the duration of the residence, alcohol consumption and smoking status.