Scoping Review of the Associations Between Perinatal Substance Use and Perinatal Depression and Anxiety

Pentecost, Ryoko; Latendresse, Gwen; Smid, Marcela C.

doi:10.1016/j.jogn.2021.02.008

Cited by 16 publications

(17 citation statements)

References 40 publications

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“…Although these figures vary by geographic location and setting, it is believed that more than 80% of women utilize opioid prescription drugs following cesarean delivery and around 54% after vaginal delivery ( 8 ). During their reproductive years, however, all women, especially those aged 18–29, are at risk for substance use disorders, which may be associated with hormonal changes during the menstrual cycle, delivery, pregnancy, lactation, and menopause ( 9 , 10 ). On the other hand, Benningfield et al discovered that 64.6% of 174 opioid-dependent pregnant women were diagnosed with at least one mental health condition, including 40% for anxiety, 33% for severe depression, and 48.8% for mood disorders ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

2023

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BackgroundPostpartum depression is the most common psychiatric disorder in pregnant women during the postpartum period and requires early detection and treatment. Previous studies have found that opioids use affects depression and anxiety disorders. Although it has long been suspected that opioids may contribute to the development of postpartum depression, observational studies are susceptible to confounding factors and reverse causality, making it difficult to determine the direction of these associations.MethodsTo examine the causal associations between opioids and non-opioid analgesics with postpartum depression, we utilized large-scale genome-wide association study (GWAS) genetic pooled data from two major databases: opioids, salicylate analgesic, non-steroidal anti-inflammatory drugs (NSAIDs), and aniline analgesics GWAS data from the United Kingdom Biobank database. GWAS data for postpartum depression were obtained from the FinnGen database. The causal analysis methods used random-effects inverse variance weighting (IVW), and complementary sensitivity analyses using weighted median, MR-Egger method, and MR-PRESSO test.ResultsIn the IVW analysis, Mendelian randomization (MR) analysis showed that opioids increased the risk of postpartum depression (OR, 1.169; 95% CI, 1.050–1.303; p = 0.005). Bidirectional analysis showed a significant causal relationship between genetically predicted postpartum depression and increased risk of opioids and non-opioid analgesics use (opioids OR, 1.118; 95% CI, 1.039–1.203; p = 0.002; NSAIDs OR, 1.071; 95% CI, 1.022–1.121; p = 0.004; salicylates OR, 1.085; 95% CI, 1.026–1.146; p = 0.004; and anilides OR, 1.064; 95% CI, 1.018–1.112; p = 0.006). There was no significant heterogeneity or any significant horizontal pleiotropy bias in the sensitivity analysis.ConclusionOur study suggests a potential causal relationship between opioids use and the risk of postpartum depression. Additionally, postpartum depression is associated with an increased risk of opioids and non-opioid analgesics use. These findings may provide new insights into prevention and intervention strategies for opioids abuse and postpartum depression.

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Section: Introductionmentioning

confidence: 99%

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

2023

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“…Evidence also suggests that perinatal psychopathology is related to poor social-emotional, cognitive, language, and motor development as well as increased risk for emotional problems in children ( Rees et al, 2019 ; Rogers et al, 2020 ). Finally, elevated psychopathology in pregnancy and the postpartum period is associated with poor maternal mental health (including substance abuse and suicidal ideation) years after birth ( Pentecost et al, 2021 ; Slomian et al, 2019 ). The COVID-19 pandemic may have dramatically increased the rates of psychopathology in pregnant and postpartum women, but the trajectory of symptoms throughout the perinatal period is unknown, a gap that impacts screening practices and intervention delivery.…”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety, and stress in pregnancy and postpartum: A longitudinal study during the COVID-19 pandemic

et al. 2023

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“…OUD treatment during re-entry is critical considering the risk for relapse and overdose following a long period of abstinence during incarceration (Binswanger, Blatchford, Mueller, & Stern, 2013). In addition to overdose risk, women with OUD experience a number of health and social challenges including high-risk pregnancies and fertility complications (Corsi & Murphy, 2021; Pentecost, Latendresse, & Smid, 2021), mental health issues including depression and PTSD (McHugh et al, 2013), and higher rates of interpersonal conflicts and intimate partner violence (Gilbert, El-Bassel, Chang, Wu, & Roy, 2012; Smith, Homish, Leonard, & Cornelius, 2012; van Reekum et al, 2020). Women who inject opioids are disproportionately vulnerable to infectious disease transmission (including HIV) due to unprotected heterosexual contact with risky partners, impaired condom use judgement, lack of agency for negotiating safer sex behaviors with partners, and being in violent and abusive relationships (Wechsberg et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Screening Incarcerated Women for Opioid Use Disorder

Staton

Tillson

Levi

et al. 2023

Journal of Drug Issues

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The overall aim of the present study is to examine the utility of the DSM OUD Checklist and the NM-ASSIST screening tools to identify symptoms consistent with OUD among incarcerated women in county jails. This study contributes to the existing literature because research on screening and assessment approaches for incarcerated women has been limited. The focus of the current study is to describe the screening procedures and study recruitment for a larger parent study focused on increasing treatment linkages. Study findings indicate a positive correlation between indicators of OUD using the two screening tools, as well as a high degree of correlation between street opioid misuse and other high-risk drug indicators (overdose and injection practices). These findings underscore the importance of outreach, screening, and intervention in real-world settings, including jails, in order to increase access to OUD treatment among this vulnerable sample of women.

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Scoping Review of the Associations Between Perinatal Substance Use and Perinatal Depression and Anxiety

Cited by 16 publications

References 40 publications

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

Depression, anxiety, and stress in pregnancy and postpartum: A longitudinal study during the COVID-19 pandemic

Screening Incarcerated Women for Opioid Use Disorder

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