Scoping the family history: Assessment of Lynch syndrome (hereditary nonpolyposis colorectal cancer) in primary care settings—A primer for nurse practitioners

Maradiegue, Ann; Jasperson, Kory; Edwards, Quannetta T.; Lowstuter, Katrina; Weitzel, Jeffrey N.

doi:10.1111/j.1745-7599.2007.00282.x

Cited by 13 publications

(13 citation statements)

References 48 publications

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“…Nursing competencies have now been developed in the United States and Europe, providing an impetus for nurses to increase their knowledge of genetics and promote effective provision of care to families and individuals (Hamilton et al, 2009;Maradiegue et al, 2008). Competency in this specialized field allows a nurse to establish lasting relationships with families, creating an environment that enables effective nursing care to be implemented.…”

Section: Discussionmentioning

confidence: 98%

“…The mutation carries a 60%-80% risk of development of colonic cancer throughout one's lifetime (Greco, 2007;Gritz et al, 2005;Maradiegue, Jasperson, Edwards, Lowstuter, & Weitzel, 2008;Razmus, Jackson, & Wilson, 2008). There is also an increased risk for other cancers, particularly endometrial cancer where the lifetime risk for females is 40%-60%.…”

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 98%

“…Nurses need to support people who have genetically inherited susceptibility to cancer by building trusting relationships, providing support regarding decision making, educating, and counseling. Patients should be cautioned about the stress that potentially develops when undertaking genetic testing (Hamilton et al, 2009;Maradiegue et al, 2008;Razmus et al, 2008;Smith et al, 2008).…”

Section: Guidance For Care Of Hdgc Patientsmentioning

confidence: 98%

“…There is also an increased risk for other cancers, particularly endometrial cancer where the lifetime risk for females is 40%-60%. Those with the genetic mutation are also predisposed to stomach, ovarian, small bowel, pancreas, ureter, renal pelvis, biliary tract, and brain cancer (Maradiegue et al, 2008).…”

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 99%

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Working Toward an Understanding of the Impact of Hereditary Cancers

Framp¹

2010

Gastroenterology Nursing

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Hereditary diffuse gastric cancer is a genetically inherited aggressive form of stomach cancer. Once the person is diagnosed as having this gene, they have a 75%-80% chance of inheriting the cancer. People who are at risk of this genetic mutation have to meet many challenges relating to the implications of the disease. An understanding is required by nurses to guide them in the provision of care for those afflicted with this inherited form of gastric cancer. A review of literature has been undertaken relating to other genetically inherited cancers including hereditary nonpolyposis colon cancer, familial adenomatous polyposis, and hereditary lobular breast cancer. The findings from the literature assist nurses in understanding the physical and psychological implications of genetically inherited cancer; however, further study is required to gain a complete understanding of the implications of hereditary diffuse gastric cancer.

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Section: Discussionmentioning

confidence: 98%

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 98%

Section: Guidance For Care Of Hdgc Patientsmentioning

confidence: 98%

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 99%

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Working Toward an Understanding of the Impact of Hereditary Cancers

Framp¹

2010

Gastroenterology Nursing

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“…Several recent population-based studies suggest that the cumulative colorectal cancer risk may be as low as 30% to 45% and that the median age of diagnosis of colorectal cancer in individuals with Lynch syndrome may be as high as 60 years when adjusted for referral bias. [9][10][11] In our case report, the patients were diagnosed at age 27, 45, and 48 years.…”

Section: Discussionmentioning

confidence: 99%

Carcinomas Associated With Lynch Syndrome: A Family History

Pınar

Ayhan

2011

International Surgery

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Lynch syndrome is a rare and inherited defect disorder. People who have Lynch syndrome are strongly predisposed to develop colorectal cancer as well as several other types of cancer. The aim of this study was to explore features of ovarian cancers arising in families with Lynch syndrome. This study was a case report based on family history examining three patients with a new diagnosis of colorectal adenocarcinoma with ovarian cancer. Family members of carriers of the mutations were counseled, and those found to be at risk were offered mutation testing. The clinical criteria of the Amsterdam II guidelines for Lynch syndrome were used in this study. This is a maternal history of a 27-year-old woman sharing the destiny of her 48-year-old mother and 45-year-old aunt, both of which were suffering from Lynch syndrome associated with ovarian cancer. The maternal grandmother and maternal uncle of this young woman also suffered from colon cancer in their forties. The medical implications for the carrier relatives were considered as the maternal branch of the family.

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Navigating the evidentiary turn in public health: Sensemaking strategies to integrate genomics into state-level chronic disease prevention programs

Senier

Smollin

Lee

et al. 2018

Social Science & Medicine

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In the past decade, healthcare delivery has faced two major disruptions: the mapping of the human genome and the rise of evidence-based practice. Sociologists have documented the paradigmatic shift towards evidence-based practice in medicine, but have yet to examine its effect on other health professions or the broader healthcare arena. This article shows how evidence-based practice is transforming public health in the United States. We present an in-depth qualitative analysis of interview, ethnographic, and archival data to show how Michigan's state public health agency has navigated the turn to evidence-based practice, as they have integrated scientific advances in genomics into their chronic disease prevention programming. Drawing on organizational theory, we demonstrate how they managed ambiguity through a combination of sensegiving and sensemaking activities. Specifically, they linked novel developments in genomics to a long-accepted public health planning model, the Core Public Health Functions. This made cutting edge advances in genomics more familiar to their peers in the state health agency. They also marshaled state-specific surveillance data to illustrate the public health burden of hereditary cancers in Michigan, and to make expert panel recommendations for genetic screening more locally relevant. Finally, they mobilized expertise to help their internal colleagues and external partners modernize conventional public health activities in chronic disease prevention. Our findings show that tools and concepts from organizational sociology can help medical sociologists understand how evidence-based practice is shaping institutions and interprofessional relations in the healthcare arena.

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Scoping the family history: Assessment of Lynch syndrome (hereditary nonpolyposis colorectal cancer) in primary care settings—A primer for nurse practitioners

Cited by 13 publications

References 48 publications

Working Toward an Understanding of the Impact of Hereditary Cancers

Working Toward an Understanding of the Impact of Hereditary Cancers

Carcinomas Associated With Lynch Syndrome: A Family History

Navigating the evidentiary turn in public health: Sensemaking strategies to integrate genomics into state-level chronic disease prevention programs

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