Scopolamine treatment and fimbria-fornix lesions: Mimetic effects on radial maze performance

Cassel, J.C.; Kelche, Christian

doi:10.1016/0031-9384(89)90002-4

Cited by 49 publications

(20 citation statements)

References 27 publications

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“…In rats, scopolamine impairs performance on this task, most likely by impairing the encoding of platform location [118,119]. Similarly, performance in the eight-arm radial maze is significantly impaired with scopolamine administration or fornix lesions [120], due to the disruption of encoding for previously visited arms. When a delay is imposed between sample and test phases of the task, the impairment in performance increases [121].…”

Section: Behavioral Work: Muscarinic Cholinergic Receptorsmentioning

confidence: 98%

Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory Feedback

2007

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Substances such as acetylcholine and glutamate act as both neurotransmitters and neuromodulators. As neuromodulators, they change neural information processing by regulating synaptic transmitter release, altering baseline membrane potential and spiking activity, and modifying long-term synaptic plasticity. Slice physiology research has demonstrated that many neuromodulators differentially modulate afferent, incoming information compared to intrinsic and recurrent processing in cortical structures such as piriform cortex, neocortex, and the hippocampus. The enhancement of afferent (external) pathways versus the suppression at recurrent (internal) pathways could cause cortical dynamics to switch between a predominant influence of external stimulation to a predominant influence of internal recall. Modulation of afferent versus intrinsic processing could contribute to the role of neuromodulators in regulating attention, learning, and memory effects in behavior.

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Section: Behavioral Work: Muscarinic Cholinergic Receptorsmentioning

confidence: 98%

Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory Feedback

2007

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“…This finding suggests an important role for the PL/IL area not in working memory capacity, but in maintaining information online or attentional focus during task completion. The medial septal nucleus (Hepler et al, 1985), nucleus basalis (Wang et al, 2006), parietal cortices (Ammassari-Teule et al, 1998), and fimbria-fornix region (Cassel and Kelche, 1989; Addy et al, 2005), are also important for the maintenance of working memory. Levin (1988) provides an excellent review of the basic psychopharmacology underlying the RAM, but highlights the importance of the cholinergic system in mediating performance, as well as its interaction with the dopaminergic system.…”

Section: Working Memorymentioning

confidence: 99%

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

Young

Powell

Risbrough

et al. 2009

Pharmacology & Therapeutics

289

323

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Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate with functional outcome, and are not well treated with current antipsychotic therapies. In order to bring together academic, industrial, and governmental bodies to address this great ‘unmet therapeutic need’, the NIMH sponsored the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. Through careful factor analysis and consensus of expert opinion, MATRICS identified seven domains of cognition that are deficient in schizophrenia (attention/vigilance, working memory, reasoning and problem solving, processing speed, visual learning and memory, verbal learning and memory, and social cognition) and recommended a specific neuropsychological test battery to probe these domains. In order to move the field forward and outline an approach for translational research, there is a need for a “preclinical MATRICS” to develop a rodent test battery that is appropriate for drug development. In this review, we outline such an approach and review current rodent tasks that target these seven domains of cognition. The rodent tasks are discussed in terms of their validity for probing each cognitive domain as well as a brief overview of the pharmacology and manipulations relevant to schizophrenia for each task.

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“…In particular, the hippocampal formation and its associated cholinergic pathways have been well studied in these RAM experiments [Dougherty et al, 1998]. Performance in the RAM task can be impaired by a variety of treatments including cholinergic antagonists [Cassel and Kelche, 1989;Beninger et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

Radial arm maze performance of rats following repeated low level microwave radiation exposure

Cobb¹,

Jauchem²,

Adair³

2003

Bioelectromagnetics

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We examined the possibility of changes in "working" memory of rats following whole body exposure to microwave (MW) radiation. During each of 10 days, we exposed rats within circularly polarized waveguides for 45 min to 2450 MHz fields at whole body SARs of 0.6 W/kg (2 micros pulses, 500 pps), followed by testing in a 12 arm, radial arm maze (RAM). Rats received a preexposure injection of one of three psychoactive compounds or saline, to determine whether a compound would interact with MW exposure to affect performance in the maze. Error rate, i.e., reentry into arms already visited, and time to criterion data for 10 consecutive days of testing were analyzed by a three way analysis of variance (ANOVA) using main effects of "exposure" and "drug" and a repeated factor of "test day." Our alpha limit for significance was P <.05. Analyzes of error rates revealed no significant exposure effect, no significant drug effect and no significant interaction between the two main factors. There was a significant difference in test days, as expected, with repeated test-trial days, which indicates that learning was accomplished. There was no significant interaction of test day and the other two factors. The results of our analyzes of time to criterion data included no significant exposure effect, a significant drug effect, a significant test day effect, and a significant interaction between drug and test day factors. Post hoc analyzes of the drug factor revealed that rats treated with either physostigmine or nalrexone hydrochloride, took significantly longer to complete the maze task than rats pretreated with saline or with naloxone methodide. We conclude that there is no evidence from the current study that exposure to of MW radiation under parameters examined caused decrements in the ability of rats to learn the spatial memory task.

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Scopolamine treatment and fimbria-fornix lesions: Mimetic effects on radial maze performance

Cited by 49 publications

References 27 publications

Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory Feedback

Neuromodulation by Glutamate and Acetylcholine can Change Circuit Dynamics by Regulating the Relative Influence of Afferent Input and Excitatory Feedback

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

Radial arm maze performance of rats following repeated low level microwave radiation exposure

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