2019
DOI: 10.5812/hmj.88269
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Scopoletin and Morin Inhibit Lactate Dehydrogenase Enzyme Activity, Which Is Critical for Cancer Metabolism

Abstract: Background: Lactate dehydrogenase (LDH) is a tetrameric enzyme that catalyzes the interconversion of pyruvate to L-lactate. The importance of this enzyme is because LDH isoenzymes are involved in cancer, heart, and liver diseases. Inhibition of this enzyme can help prevent and treat different diseases. Morin is a flavonoid found in the Moraceae family and scopoletin is a coumarin found in Scopolia genus. Objectives: The aim of this study was to determine the effect of morin and scopoletin as two natural produc… Show more

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Cited by 5 publications
(3 citation statements)
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“…The K d was calculated by plotting the log(fluorescence change/fluorescence intensity) versus log(oxaloacetate concentration). K d was calculated by the modified form of a Stern-Volmer plot in which the vertical intercept is log(1/K d ) 49 . The assay was performed at room temperature.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The K d was calculated by plotting the log(fluorescence change/fluorescence intensity) versus log(oxaloacetate concentration). K d was calculated by the modified form of a Stern-Volmer plot in which the vertical intercept is log(1/K d ) 49 . The assay was performed at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…280 nm, em. 340 nm) from tryptophan was measured and the K d was calculated by the modified form of a Stern-Volmer plot in which the vertical intercept is log(1/K d ) 49 . f 0 : fluorescence intensity without OAA treatment, f: fluorescence intensity with OAA treatment at the indicated concentrations.…”
Section: Figurementioning
confidence: 99%
“…Morin (MO), a flavonoid isolated from the Moraceae family, inhibited the enzymatic activity of LDH. MO modulated the conformation and inhibited the catalytic activity of LDH [144]. Furthermore, QUE effectively suppressed cancer growth and proliferation in MCF-7 and MDA-MB-231 cells and decreased the level of glycolysis-related enzymes including LDHA [119].…”
Section: Additional Glycolytic Enzymesmentioning
confidence: 99%