Scoring for Hemorrhage Severity in Traumatic Injury

Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics

“…While there may be interest in the underlying causes of edema and the molecular etiology of changes in the bioimpedance associated with the development of edema, the present perspective seeks only to holistically stratify the VCA based on the fusion of pathophysiology analytical data, clinical expert data, and MMBIS data to yield stratified performance. The authors have employed similar approaches in the development of a Hemorrhagic Trauma Severity scoring system [ 23 ] for the hemorrhaging trauma patient [ 60 ].…”

“…Thus, 0 = no ischemic damage (no edema), 1 = mild ischemic damage (mild edema, no erythema), 2 = moderate ischemic damage (edema and erythema), and 3 = severe ischemic damage (epidermolysis and/or necrosis). Such approaches may be evaluated by passing the discrete data to the classifier or by passing derivative data, such as biomarker scores, to the classifier [ 60 , 65 ]. Among the relevant scores is the Hemorrhage Intensive Severity and Survivability (HISS) score, which aggregates molecular metabolite data into a delineation of hemorrhagic shock states [ 23 ], and the emerging inflammatory status score, which aggregates molecular indicators of the inflammation status into a delineation of inflammation states [ 66 ].…”