Scoring system for monitoring oral lichenoid lesions: A preliminary study

Piboonniyom, Siribang-on; Treister, Nathaniel S.; Pitiphat, Waranuch; Woo, Sook‐Bin

doi:10.1016/j.tripleo.2004.07.013

Cited by 113 publications

(105 citation statements)

References 39 publications

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“…Oral mucosal changes were evaluated with a scale developed for scoring oral mucositis lesions and oral lichen planus – a condition clinically very similar to oral cGVHD (14). …”

Section: Methodsmentioning

confidence: 99%

Salivary Gland Involvement in Chronic Graft-Versus-Host Disease: Prevalence, Clinical Significance, and Recommendations for Evaluation

Imanguli

Atkinson

Mitchell

et al. 2010

Biology of Blood and Marrow Transplantation

120

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Although xerostomia is a commonly reported complaint in patients with chronic graft versus host disease (cGVHD), criteria for evaluating the prevalence and characteristics of salivary gland involvement have not been well defined in this patient population. Prior studies also do not make distinction between salivary and mucosal oral cGVHD. We have systematically evaluated sicca symptoms and signs in a large cohort of patients with cGVHD (N=101) using instruments widely used to study Sjogren’s Syndrome. Xerostomia was reported by 77% of the patients and was associated with xerophthalmia in all cases but one. Twenty-seven percent had salivary flow rates of ≤0.2 ml/min, 16% had rates ≤0.1 ml/min. Histopathological changes consisting of mononuclear infiltration and/or fibrosis/atrophy, were present in all patients with salivary dysfunction. Importantly, there was no correlation of salivary and oral mucosal involvement in cGVHD. Patients with cGVHD-associated salivary gland involvement had lower oral cavity-specific quality of life and body mass index. In conclusion, salivary gland involvement is a common and clinically distinct manifestation of cGVHD. Formal evaluation of salivary function using standardized criteria is necessary and may be incorporated as outcome measure in clinical trials of cGVHD.

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“…Oral mucosal changes were evaluated with a scale developed for scoring oral mucositis lesions and oral lichen planus – a condition clinically very similar to oral cGVHD (14). …”

Section: Methodsmentioning

confidence: 99%

Salivary Gland Involvement in Chronic Graft-Versus-Host Disease: Prevalence, Clinical Significance, and Recommendations for Evaluation

Imanguli

Atkinson

Mitchell

et al. 2010

Biology of Blood and Marrow Transplantation

120

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“…It was scored from 0 to 10 purely based on patient's response (Score 0: no oral discomfort; Score 10: extreme oral discomfort). On each appointment, clinical examination was performed to record the severity of the individual lesion by using Piboonniyom REU [13] (Reticular, Erythematous and Ulceration) severity score, which is based on the presence of reticular, atrophic, erosive/ulcerative areas of the lesion(s). Individual lesion was scored as follows (Table 1): Maximum size of the lesion was the distance between two opposite largest outside edges of the lesion.…”

Section: Patientsmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

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Oral lichen planus (OLP) is a chronic inflammatory, immunologically mediated mucocutaneous disorder. Numerous topical and systemic therapies have been used in the treatment of OLP. Most of the current available treatments are palliative rather than curative. Corticosteroids are considered as the main treatment drugs. Unfortunately, some patients may develop refractory or resistance to corticosteroids therapy. This study aims to evaluate and compare the efficacy of lycopene and prednisolone in the management of OLP. This was a double-blind randomized comparative study in which clinically and histopathologically proven symptomatic OLP patients were enrolled and divided into two groups. Lycopene group received oral lycopene 4 mg/day (n=13) and prednisolone group received oral prednisolone 40 mg/day (n=15) for eight consecutive weeks. Assessments were made at baseline and after 2, 4, 6 and 8 weeks of treatment, based on the Numerical Rating Scale (NRS) and the Piboonniyom REU (Reticular, Erythematous and Ulceration) severity score. From the results obtained, the reduction of NRS burning sensation scores was statistically significant after two weeks of treatment in both groups. REU severity scores were decreased by 74% (p=0.005) and 91% (p=0.001) in lycopene and prednisolone groups respectively. Complete remission (EI=100%) of lesion was observed in two (15.4%) patients treated with lycopene and ten (66.7%) patients treated with prednisolone. However, the overall treatment response was

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“…To better present the clinical forms of OLP, RAE (reticular, atrophic and erosive lesion) scoring system was used in this study to measure the severity of OLP in its different clinical forms. It was an improvement of REU (reticular, erosive and ulcerative lesion) scoring system, and more practical [16]. Surface areas of atrophy and erosion were measured with a sterile flexible periodontal scale probe, and were estimated in squared millimetres.…”

Section: Clinical Assessmentmentioning

confidence: 99%

Increased B7-H1 Expression on Peripheral Blood T Cells in Oral Lichen Planus Correlated with Disease Severity

et al. 2012

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Scoring system for monitoring oral lichenoid lesions: A preliminary study

Cited by 113 publications

References 39 publications

Salivary Gland Involvement in Chronic Graft-Versus-Host Disease: Prevalence, Clinical Significance, and Recommendations for Evaluation

Salivary Gland Involvement in Chronic Graft-Versus-Host Disease: Prevalence, Clinical Significance, and Recommendations for Evaluation

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Increased B7-H1 Expression on Peripheral Blood T Cells in Oral Lichen Planus Correlated with Disease Severity

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