<scp>2‐Mercaptonicotinoyl</scp> glycine prevents <scp>UV</scp>‐induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study

de Dormael, R.; Sextius, P.; Bourokba, N.; Mainguene, E.; Tachon, R.; Gaurav, K.; Jouni, H.; Bastien, P.; Diridollou, S.

doi:10.1111/jocd.16200

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…A standardized clinical protocol, randomized, double-blind and interindividual trial, was designed to assess the skin lightening performance of a given active versus its vehicle with ascorbic acid 7% taken as a reference. 16,17 Ascorbic acid is a recognized anti-pigmenting/depigmenting agent with antioxidative and deactivation of tyrosinase pathways, 18 whereas the concentration of 7% has been demonstrated in the present protocol during unpublished experiments as the minimum to obtain an early and stable efficacy. The global protocol of each study, of 6 week-duration, is shown in Table 1 and remains strictly identical for all compounds.…”

Section: Clinical Screening Protocolmentioning

confidence: 81%

“…It has been demonstrated that 2-MNG acts within the melanin-synthesis circuit and can inhibit both the early darkening photoreactions and the formation of new melanin pigments. 13,14,16 As such and in contrast with the other reference molecules, we can posit that the strength of 2-MNG is its ability to exhibit both anti-pigmenting and depigmenting properties and this dual efficacy remains thus far unparalleled.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, 2-MNG had a broad spectrum of action in melaninrich skin, which attest to its versatility and inclusivity. 16 While 2-MNG is a promising candidate for safe skin tone and hyperpigmentation management, it is important to understand the anti-pigmenting and depigmenting activity of 2-MNG with respect to existing molecules. Here, the use of a Bayesian network meta-analysis (BNMA) is reported to map and rank the efficacy of 2-MNG together with thirteen other reference molecules including tyrosinase inhibitors and antioxidants currently used for management of hyperpigmentation.…”

Section: Introductionmentioning

confidence: 99%

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A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

Muller,

Flament,

Jouni

et al. 2024

Acad Dermatol Venereol

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IntroductionHyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti‐pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2‐mercaptonicotinoyl glycine (2‐MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in vitro and in vivo.ObjectivesA Bayesian network meta‐analysis (BNMA) was conducted to map and rank the anti‐pigmenting and depigmenting efficacy of 2‐MNG 0.5% on UV daylight (UVDL)‐induced pigmentation together with 13 other reference molecules. A comparison in the kinetics of 2‐MNG 0.5% was also performed.MethodologyFourteen studies were conducted, for each, on 15–30 women of skin phototype III in Shanghai, China and Paris, France. The products were applied on mini zone, in randomized and blinded protocol, on the back, 5 days a week during 6 weeks, at a dose of 4 mg/cm2. During the second week, volunteers were exposed under to varying minimum erythemal dose of UVDL during 4 consecutive days—adapted to obtain a similar induction of skin pigmentation regardless of the population. Assessments were performed instrumentally using Chromameter®. Ascorbic acid 7% was used as a positive control for all experiments. A Bayesian network meta‐analysis was then established to map and follow the kinetics of 2‐MNG 0.5% performance with 13 reference molecules (glutathione 2%, kojic acid 1%, hydroquinone 4%, ascorbyl glucoside 2%, niacinamide 4%, etc.).Results2‐MNG 0.5% dominated the ranking at all time points with a significant high probability of strong efficacy against UVDL‐induced pigmentation. Ascorbic acid 7% ranks second after 4 days of irradiations (D12) whereas hydroquinone 4% ranks second 1 month after irradiations (D40). In the kinetics, 2‐MNG at 0.5% was effective as from the end of irradiations (D12) to the study endpoint (D40). This suggested an immediate and persistent efficacy across all timepoints evaluated.ConclusionThe BNMA revealed a rapid and lasting efficacy of 2‐MNG 0.5% on the anti‐pigmenting and depigmenting phases of the clinical protocol. 2‐MNG 0.5% ranked first, with immediate and lasting effect compared to 13 other references. This study is the first allowing comparison between reference anti‐pigmenting and depigmenting agents and will help clinicians for proposing the most effective approach for their patients.

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Section: Clinical Screening Protocolmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

Muller,

Flament,

Jouni

et al. 2024

Acad Dermatol Venereol

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2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Sextius,

Warrick,

Prévot‐Guéguiniat

et al. 2024

Pigment Cell Melanoma Res

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Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High‐throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thiopyridinone backbone and select 2‐mercaptonicotinoyl glycine (2‐MNG) as exhibiting the most favorable balance between the impact on water footprint, skin penetration potential and performance. The effectiveness of 2‐MNG was confirmed by topical application on pigmented reconstructed epidermis and human skin explants. In addition, experiments have shown that unlike most melanogenesis inhibitors on the market, this molecule is not a tyrosinase inhibitor. 2‐MNG binds to certain melanin precursors, preventing their integration into growing melanin and leading to inhibition of eumelanin and pheomelanin synthesis, without compromising the integrity of melanocytes.

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Addressing the Unmet Need in Acne Management: A Novel Dermocosmetics Guideline Tailored to Asian Patient Subgroups

Kim,

Ko,

Suh

et al. 2024

Cosmetics

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Acne, a commonly treated skin disease, requires control of one’s daily routine for an optimal outcome. As skincare products continue to advance, and with the introduction of dermocosmetics (active cosmetics, functional cosmetics, cosmeceuticals), it is necessary for clinicians to stay updated and give professional guidance. Following a literature review, a panel discussed and, using an online review process, explored the available acne dermocosmetics and convened to develop consensus statements on acne skincare incorporating patient- and treatment-related factors. Recommendations tailored to several distinct patient subgroups, namely, preadolescent acne, adolescent/adult acne, acne with comorbid atopic dermatitis, acne in pregnancy, drug-induced acne, and acne cosmetica, were generated to maximize the use of dermocosmetics in acne management. In adolescent and adult acne, products with active ingredients that mark key aspects of acne pathophysiology are called for; in atopics, agents which protect and restore the skin barrier are primarily considered; and in the preadolescent age group and pregnant and lactating women, the use of acne dermocosmetics should be prioritized as there are limited treatment options. While skincare alone is often sufficient for mild acne and for maintenance, adjunctive skincare can enhance treatment efficacy as well as patient adherence in various settings. This guideline seeks to offer insights into acne dermocosmetics and provide skincare recommendation tailored to Asian patient subgroups.

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2‐Mercaptonicotinoyl glycine prevents UV‐induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study

Cited by 3 publications

References 21 publications

A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation

2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity

Addressing the Unmet Need in Acne Management: A Novel Dermocosmetics Guideline Tailored to Asian Patient Subgroups

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