4‐PBA inhibits hypoxia‐induced lipolysis in rat adipose tissue and lipid accumulation in the liver through regulating ER stress

Abstract

Ascent to high altitude is associated with multi physiological and metabolic responses to counter with the stress of hypobaric hypoxia.White adipose tissue (WAT) is the largest reservoir of energy reserves, which stores energy in the form of triglyceride in lipid droplets. WAT plays an essential role in maintaining the whole-body lipid metabolism homeostasis and accumulated evidence has demonstrated the functional association between adipose tissue and liver (Natarajan et al., 2017;Sun et al., 2012). In our previous work, hypobaric hypoxia