<scp>A</scp>lterations of the circadian system in <scp>P</scp>arkinson's disease patients

Fifel, Karim

doi:10.1002/mds.26865

Cited by 53 publications

(71 citation statements)

References 135 publications

(208 reference statements)

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“…However, a relevant influence of medications, motor, and non-motor symptoms (in particular cognitive disturbances and hallucinations) has been postulated also for these findings (6). …”

Section: Circadian Rhythm Dysfunction In Ad and Pdmentioning

confidence: 99%

“…This suggests that in PD, the circadian imbalance, at least in the early phase, is not primarily due to a master clock pathology (6). This is consistent with the finding that PD patients in the early stage of the disease do not exhibit frank circadian rhythm abnormalities, such as for melatonin and other hormones (6, 83).…”

Section: Circadian Rhythm Dysfunction In Ad and Pdmentioning

confidence: 99%

“…They are both characterized by the frequent occurrence of sleep problems and circadian rhythm dysfunction (3–6). In the last decade, the role of the eye in influencing and regulating circadian rhythms has been clarified, starting from the discovery of the intrinsically photosensitive melanopsin-containing retinal ganglion cells (mRGCs) (7, 8).…”

Section: Introductionmentioning

confidence: 99%

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Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

et al. 2017

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There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The characterization of the circadian dysfunction parallels the mounting evidence that the hallmarks of neurodegeneration also affect the retina and frequently lead to loss of retinal ganglion cells (RGCs) and to different degrees of optic neuropathy. In the RGC population, there is the subgroup of cells intrinsically photosensitive and expressing the photopigment melanopsin [melanopsin-containing retinal ganglion cells (mRGCs)], which are now well known to drive the entrainment of circadian rhythms to the light–dark cycles. Thus, the correlation between the pathological changes affecting the retina and mRGCs with the circadian imbalance in these neurodegenerative diseases is now clearly emerging, pointing to the possibility that these patients might be amenable to and benefit from light therapy. Currently, this connection is better established for AD and PD, but the same scenario may apply to other neurodegenerative disorders, such as Huntington’s disease. This review highlights similarities and differences in the retinal/circadian rhythm axis in these neurodegenerative diseases posing a working frame for future studies.

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“…However, a relevant influence of medications, motor, and non-motor symptoms (in particular cognitive disturbances and hallucinations) has been postulated also for these findings (6). …”

Section: Circadian Rhythm Dysfunction In Ad and Pdmentioning

confidence: 99%

Section: Circadian Rhythm Dysfunction In Ad and Pdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

et al. 2017

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“…Melatonin reduces the toxicity of beta-amyloid and prevents the death of cells in experimental AD models, and also reduces oxidative stress in PD models [44][45][46]48].…”

Section: Melatonin Involvement In the Circadian Rhythms Regulationmentioning

confidence: 99%

“…), which is usually accompanied by the SCN lesion. On the other hand, a rhythmic change in the states of sleep and wakefulness is quite an autonomous process and persists in people deprived of external time sensors, which emphasizes the dependence of sleep on the activity of the leading pacemaker [44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Features of Circadian Rhythms in Patients with Cerebrovascular Diseases

Костенко¹,

Петрова²

2018

Circadian Rhythm - Cellular and Molecular Mechanisms

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The chapter describes in detail the pathogenetic role of desynchronosis in the development of cerebrovascular diseases (CVD). The data of domestic and foreign literature on the study of desynchronosis are presented. The role of melatonin in the regulation of circadian rhythms (CR) is shown. Pathological changes in CR affect sleep disturbance, emotional and cognitive disorders. It is demonstrated the need of the further study of the prevalence and structure of desynchronosis in patients with CVD. The search of the most significant factors of desynchronosis development in patients with vascular diseases is of great scientific and practical significance. The importance of creating and introducing diagnostic and therapeutic algorithms for chronodiagnostics and chronotherapy of CVD into everyday practical activities. The effectiveness of melatonin for the normalization of sleep and CR in patients with insomnia, acute stroke, depressive disorders is shown. Complex therapy of the patients with CVD taking into account chronobiological disorders allows to eliminate the adverse effect of sleep disorders and CR on the regulation of the cardiovascular system and improve the efficiency of rehabilitation.

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Neuropathology of Circadian Alterations in Parkinson Disease

Fifel

2019

JAMA Neurol

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To the Editor In a recent study published in JAMA Neurology, De Pablo-Fernàndez et al 1 reported what is, to our knowledge, the first detailed histological study that examined the neuropathological status of the suprachiasmatic nucleus (SCN) and pineal gland in 3 neurological conditions: Parkinson disease (PD), multiple system atrophy, and progressive supranuclear palsy. This letter will focus on PD. De Pablo-Fernàndez et al 1 stained 8-μm thick sections that were prepared from postmortem formalinfixed hypothalamic and pineal tissue for α-synuclein. 1 This protein is used as a marker for Lewy bodies and neurites that are hallmark neuropathological features for PD. 2 The authors found Lewy depositions in 9 of 13 SCN cases (69.2%) and in only 2 of 17 pineal gland samples (11.8%). Using a semiquantitative scoring system with a 5-level expression intensity scale (absent, mild, moderate, severe, or very severe), the intensity of the staining in the SCN was evaluated as mild to moderate. In the pineal gland, only mild α-synuclein depositions in the form of Lewy neurites were found in 2 patients with PD. 1 Caution should be practiced in interpreting these results. The brain tissues that were used in this study were obtained from patients with advanced PD with a mean (range) disease duration of 14.3 (7.2-20.0) years. The advanced stage of the disease was also confirmed by the Braak neuropathological stages 5 and 6 of all PD brains that were examined. 1 At such stages, available studies that examined circadian rhythms in PD have shown substantial insults to both the entrainment and the amplitude of several behavioral, physiological, and molecular circadian parameters, including melatonin rhythm. 3,4 Consequently, the mild and quasinormal phenotypes of α-synuclein depositions that were reported in this study in the SCN and pineal gland, respectively, might underestimate the extent of circadian alterations in PD. This could be associated with the weak sensitivity of Lewy depositions and α-synuclein staining to reliably inform about physiological dysfunctions in PD. 2 Supporting this interpretation is the absence of a positive correlation reported by De Pablo-Fernàndez et al 1 between SCN α-synuclein deposition and Lewy bodies pathology in the rest of the brains of patients with PD. 4 Another important finding from De Pablo-Fernàndez et al 1 is the neuropathological heterogeneity found in the SCN and pineal glands. Five of 13 SCNs (38.5%) and most pineal glands (15 of 17 cases [88.2%]) showed no signs of neuropathological changes even though patients with PD from whom tissue was Letters jamaneurology.com (Reprinted)

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Alterations of the circadian system in Parkinson's disease patients

Cited by 53 publications

References 135 publications

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Features of Circadian Rhythms in Patients with Cerebrovascular Diseases

Neuropathology of Circadian Alterations in Parkinson Disease

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