The escalating threat of easily transmitted diseases poses a huge challenge to government institutions and health systems worldwide. Advancements in information and communication technology offer a promising approach to effectively controlling infectious diseases. This article introduces a comprehensive framework for predicting and preventing zoonotic virus infections by leveraging the capabilities of artificial intelligence and the Internet of Things. The proposed framework employs IoT‐enabled smart devices for data acquisition and applies a fog‐enabled model for user authentication at the fog layer. Further, the user classification is performed using the proposed ensemble model, with cloud computing enabling efficient information analysis and sharing. The novel aspect of the proposed system involves utilizing the temporal graph matrix method to illustrate dependencies among users infected with the zoonotic flu and provide a nuanced understanding of user interactions. The implemented system demonstrates a classification accuracy of around 91% for around 5000 instances and reliability of around 93%. The presented framework not only aids uninfected citizens in avoiding regional exposure but also empowers government agencies to address the problem more effectively. Moreover, temporal mining results also reveal the efficacy of the proposed system in dealing with zoonotic cases.