<scp>ABO</scp> blood group and risk of <scp>COVID</scp>‐19 infection and complications: A systematic review and meta‐analysis

Gutiérrez-Valencia, Marta; Leache, Leire; Librero, Julián; Jericó, Carlos Rilova; Germán, Mónica Enguita; García-Erce, José Antonio

doi:10.1111/trf.16748

Cited by 32 publications

(49 citation statements)

References 32 publications

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Section: Discussionmentioning

confidence: 99%

“…Conflicting findings are present in studies that have investigated the association of the ABO blood group and COVID-19 susceptibility and severity (16,41,(52)(53)(54)(55)(56)(57)(58). Most systematic reviews and meta-analysis studies have demonstrated a decreased risk in susceptibility and severity among patients with COVID-19 in O group (10,13,28,54,59), whereas other reviews and manuscripts demonstrated no significant association (39,53,(60)(61)(62). These differences may be due to ascertainment bias, multiple confounding effects, diverse studies populations and their geographics locations, presence and adjustment to comorbidities, and case and control selection criteria.…”

Section: Discussionmentioning

confidence: 99%

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Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

et al. 2022

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Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

et al. 2022

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“…Recently published systematic reviews that investigated the relationship between the ABO blood group and the occurrence of COVID-19, found that individuals belonging to O blood group type are less susceptible to SARS-CoV-2 infection compared to those non-O group [ 2 , 3 , [5] , [6] , [7] ]. However, these syntheses were not adjusted and showed high heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Role of the AB0 blood group in COVID-19 infection and complications: A population-based study

Enguita-Germán

Librero

Leache

et al. 2022

Transfusion and Apheresis Science

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Since the beginning of the COVID-19 pandemic, the ABO blood group has been described as a possible biological marker of susceptibility for the disease. This study evaluates the role of ABO group on the risk of SARS-CoV-2 infection and related complications in a population-based cohort including 87,090 subjects from the Navarre population (Northern Spain) with no history of SARS-CoV-2 infection and with known ABO blood group, after one year of the pandemic (May 2020 – May 2021). The risk of infection, hospitalization, Intensive Care Unit (ICU) admission and death was analyzed using multivariate logistic regression, adjusting for possible confounding variables. A lower risk of infection was observed in group 0 vs non-0 groups [OR 0.94 (95%CI 0.90-0.99)], a higher risk of infection in group A vs non-A groups [OR 1.09 (95%CI 1.04-1.15)] and a higher risk of infection in group A vs group 0 [OR 1.08 (95CI 1.03-1.14)] (when the 4 groups are analyzed separately). No association was observed between blood groups and hospitalization, ICU admission, or death in SARS-CoV-2 infected subjects. Regarding the risk of SARS-CoV-2 infection, we observed a protective role of group O and a greater risk in the A group.

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“…The presence of A and B antigens has been associated with increased susceptibility to the development of infections, cardiovascular diseases, and cancer [ 8 ]. Since the beginning of the COVID-19 pandemic, several publications have reported that there was a relationship between ABO blood group type and SARS-CoV-2 infection, noting that individuals with the O blood group are least likely to be infected [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. This association between blood group and coronavirus infection had already been observed in SARS infection in 2005, where individuals with the O blood group were less likely to be infected by the virus [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between ABO Blood Group Distribution and COVID-19 Infection in Patients Admitted to the ICU: A Multicenter Observational Spanish Study

Jericó

Zalba-Marcos²,

Quintana-Díaz

et al. 2022

JCM

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Since the beginning of the COVID-19 pandemic in December 2019, a relationship between the ABO blood group type and the novel coronavirus SARS-CoV-2, the etiological agent of COVID-19, has been reported, noting that individuals with the O blood group are the least likely to be infected. Spain is one of the most badly affected countries worldwide, with high rates of patients diagnosed, hospitalized, and deceased due to COVID-19 infection. The present study aimed to analyze the possible relationship of ABO in COVID-19 patients hospitalized in different Spanish centers during the first wave of the COVID-19 pandemic, for which the ABO group was available. Physicians from the transfusion services of different Spanish hospitals, who have developed a multicenter retrospective observational study, were invited to participate voluntarily in the research and 12,115 patients with COVID-19 infection were admitted to the nine participating hospitals. The blood group was known in 1399 cases (11.5%), of which 365 (26.1%) were admitted to the ICU. Regarding the distribution of ABO blood groups, a significant increase in the non-O blood groups and reduction for the O blood group was observed in patients hospitalized due to COVID-19, compared to the reference general population. Among the patients admitted to the ICU, after multivariate analysis, adjusted for the rest of the confounding variables, patients with the O blood group presented a significantly lower risk for admission to the ICU. We conclude that an association was observed between patients with the O blood group and their lower susceptibility to SARS-CoV-2 infection, both for those admitted to the hospitalization ward and for those who required admission to the ICU.

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ABO blood group and risk of COVID‐19 infection and complications: A systematic review and meta‐analysis

Cited by 32 publications

References 32 publications

Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

Role of the AB0 blood group in COVID-19 infection and complications: A population-based study

Relationship between ABO Blood Group Distribution and COVID-19 Infection in Patients Admitted to the ICU: A Multicenter Observational Spanish Study

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