ADMEof Cardiovascular Drugs

Abstract

This chapter explores the metabolism and disposition of drugs for cardiovascular therapy. The general characteristics of drug metabolizing enzymes, drug transporters, and drug–drug interactions are described in the context of cardiovascular drug disposition, as is the impact of drug metabolites, pharmacogenetics and biomarkers. The body of the chapter is a survey of cardiovascular drug classes with emphasis on primary factors involved in drug metabolism and disposition. The chapter concludes with a brief discussion on the future of cardiovascular drug metabolism.