2023
DOI: 10.1002/tox.23958
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Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK‐mediated endothelial ferroptosis

Yanchao Hu,
Xu Gu,
Yan Zhang
et al.

Abstract: PurposeVitamin D receptors (VDR) play important roles in cardiovascular, immune, metabolic and other functions. Activation of VDR may help improve endothelial dysfunction, atherosclerosis, vascular calcification, and cardiac hypertrophy. However, the specific target genes and mechanisms of VDR in improving Human Umbilical Vein Endothelial Cell (HUVEC) functions remain unclear. This study aims to investigate the function and mechanism of VDR in HUVECs.MethodsEndothelial dysfunction cell model was constructed by… Show more

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Cited by 5 publications
(2 citation statements)
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“…A growing body of evidence underscores the pivotal role of ferroptosis in the pathogenesis of numerous cardiovascular diseases by disrupting normal cellular functions [ 31 33 ]. For instance, oxidized low-density lipoprotein (ox-LDL) has been implicated in the induction of endothelial dysfunction and ferroptosis through the modulation of ADM transcription and the activation of the AMPK signaling cascade [ 34 ]. Furthermore, Fang et al have elucidated that ferroptosis is instrumental in the pathogenesis of DOX-induced cardiomyopathy [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…A growing body of evidence underscores the pivotal role of ferroptosis in the pathogenesis of numerous cardiovascular diseases by disrupting normal cellular functions [ 31 33 ]. For instance, oxidized low-density lipoprotein (ox-LDL) has been implicated in the induction of endothelial dysfunction and ferroptosis through the modulation of ADM transcription and the activation of the AMPK signaling cascade [ 34 ]. Furthermore, Fang et al have elucidated that ferroptosis is instrumental in the pathogenesis of DOX-induced cardiomyopathy [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, ferroptosis inducers and inactivation of dihydroorotate dehydrogenase work together to induce mitochondrial lipid peroxidation [89]. A recent study reported that vitamin D receptors inhibit ferroptosis by regulating the AMP-activated protein kinase signaling pathway and adrenomedullin transcription, thereby alleviating lipid deposition in vivo and in vitro [90].…”
mentioning
confidence: 99%