<scp>Alpha‐lipoic</scp> acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection

Barut, Elif Nur; Engin, Seçkin; Sayğın, İsmail; Kaya-Yasar, Yesim; Arici, Seyma; Sezen, Sena F.

doi:10.1002/ddr.21791

Cited by 7 publications

(4 citation statements)

References 46 publications

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“…In addition, ALA reversed MTXinduced inflammatory hints because it notably reduced the level of TNF-α, which is consistent with the earlier stated antioxidant/anti-inflammatory effects of ALA. [20] Other studies have also shown that ALA has anti-inflammatory effect by decreasing the level of TNF-α. [41,42] Furthermore, ALA reversed MTX-induced ROS-mediated damage, inflammation, and disruption in the testis as evidenced by decreasing iNOS and TNF-α immunoreactivity and histopathological improvement compared with MTX alone, which is in agreement with prior studies. [20] Here, we showed that the ALA-treated decline in NO levels was attributable to downregulation of iNOS expressions in the testis.…”

Section: Discussionsupporting

confidence: 90%

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

Armağan

Bayram

CANDAN>³

et al. 2023

Journal of Contemporary Medicine

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Aim: The toxic effects of methotrexate, a chemotherapeutic, on the testicles is an important side effect. Methotrexate impairs spermatogenesis and fertility and causes oligospermia. In this study, we aimed to minimize the testicular toxicity, those being the side effects of methotrexate, by using the probable protective effects of α-lipoic acid, a potent antioxidant. Materials and Methods: Twenty-eight male Sprague Dawley rats that we employed in this research were separated into three groups as control (0.09% PS) (n=8), methotrexate (20 mg/kg) (n= 10), and methotrexate (20 mg/kg) + α-lipoic acid (100 mg/kg) (n= 10). We performed a histochemical analysis on the testicular tissue of rats using hematoxylin-eosin and Masson’s trichrome. We performed an immunohistochemical analysis using inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) primer ab. Results: The histochemical evaluation revealed a significant decrease in the methotrexate-induced testicular toxicity in the α-lipoic acid-treated groups. On the other hand, TNF-α and iNOS immunostaining results were also observed to support these results. Conclusion: The treatment use of α-lipoic acid succeeded in protecting against methotrexate-induced testicular damage through an α-lipoic acid-mediated antioxidant and anti-inflammatory mechanisms. α-lipoic acid can be used in combination with methotrexate as a protector against side effects during anticancer therapy. In the present study, it was shown that α-lipoic acid can be used in combination with methotrexate as a protector against side effects during anticancer treatment.

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Section: Discussionsupporting

confidence: 90%

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

Armağan

Bayram

CANDAN>³

et al. 2023

Journal of Contemporary Medicine

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“…Originally, this organosulphur compound is located in the mitochondria and acts as a cofactor for pyruvate dehydrogenase/α‐ketoglutarate dehydrogenase complexes in the biological system. Recent studies have been focused on its therapeutical potentials such as nephroprotective, [2] anti‐inflammatory, [3] anti‐apoptotic, [4] and neuroprotective [5] properties. Interestingly, several clinical studies have suggested a promising ameliorative potential of α‐LA against liver diseases by improving serum adiponectin and IL‐6 levels [6] and reducing tissue oxidative damage and hypoxia [7] .…”

Section: Introductionmentioning

confidence: 99%

Alpha‐Lipoic Acid Modulates the Oxidative and Inflammatory Responses Induced by Traditional and Novel Tobacco Products in Human Liver Epithelial Cells

Reıs

Kolci

Bahcivan

et al. 2023

Chemistry & Biodiversity

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Smoking has been associated with NAFLD recently, thus might be a contributing factor for liver disease progression. In this study, we identified the modulative action of α-lipoic acid (α-LA), an organosulphur compound, towards heated tobacco product (HTP) and cigarette smoke extract (CSE)-induced oxidative stress and inflammation in human liver HepG2 cells. The cells were pre-treated with α-LA and exposed to tobacco extracts, and cytotoxicity, oxidative response (SOD, CAT activities and GSH, MDA levels), inflammation (nitrite, IL-6, AhR levels), and liver function (AST/ALT) were assessed. According to the results, a notable increase in oxidative response was observed with CSE, whereas GSH depletion and decreased SOD activity were the key toxicological events induced by HTP (p < 0.05). The oxidative and inflammatory responses were ameliorated with α-LA treatment, particularly through GSH restoration and IL-6 modulation. To conclude, these findings on α-LA might contribute to the design of novel adjuvant therapies for people exposed to tobacco smoke.

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“…However, NSAIDs have various adverse effects on the gastrointestinal tract, liver, nervous, urinary tract, blood, and cardiovascular system, especially those occurring in the stomach. These effects can lead to issues, such as gastric mucosal erosion, ulcer, hemorrhage, and perforation [ 2 ]. In recent decades, with the increasing clinical application range and dosage, the incidence rate of NSAIDs-related gastric ulcer is also on the rise [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats

et al. 2023

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The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats. The rats were divided into the following groups: normal group, model group, omeprazole group (0.02 g/kg), and WOPs groups (0.22, 0.44, and 0.88 g/kg, respectively). After receiving gavage once per day for 30 consecutive days, the rats were injected intraperitoneally with indomethacin 48 mg/kg to induce gastric ulcers. Then, the serum inflammatory cytokines and gastric prostaglandin E2 (PGE2), oxidative stress-related indicators, and the RNA expression of COX-1 and COX-2 were measured. The results revealed that WOPs confer significant gastroprotection on gastric ulcers caused by indomethacin, regulating inflammatory cytokines, oxidative stress, and prostaglandins synthesis, and enhancing the expression of COX-1 and COX-2 in gastric tissue, thus exerting its protective effect on gastric mucosa. The gastroprotective mechanism may be related to the involvement of the arachidonic acid metabolism and upregulation of tryptophan, phenylalanine, tyrosine, and alpha-Linolenic acid metabolism synthesis in vivo.

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Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection

Cited by 7 publications

References 46 publications

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

The Effect of Alpha-Lipoic Acid against Methotrexate on Testicular Damage in Rats

Alpha‐Lipoic Acid Modulates the Oxidative and Inflammatory Responses Induced by Traditional and Novel Tobacco Products in Human Liver Epithelial Cells

The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats

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