<scp>ANGPTL</scp>4 regulates the metastatic potential of oral squamous cell carcinoma

Tanaka, Junichi; Irié, Tarou; Yamamoto, Gou; Yasuhara, Rika; Isobe, Tomohide; Hokazono, Chie; Tachikawa, Tetsuhiko; Kohno, Yohko; Mishima, Kenji

doi:10.1111/jop.12212

Cited by 29 publications

(27 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of ANGPTL4 involved in the regulation of angiogenesis remains controversial [ 15 , 22 , 23 ]. It has been demonstrated that ANGPTL4 could inhibit VEGF-induced cell proliferation, migration, and tubule formation in HUVECs and this effect was via the suppression of Raf/MEK/ERK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…The role of ANGPTL4 in lipid metabolism has been well investigated [ 16 , 18 ], however, the role of ANGPTL4 in tumor biology remains largely undefined. Some reports suggested its tumor-suppressive function [ 19 , 20 ], but others claimed its oncogenic function [ 21 – 23 ]. The controversial results drive the need of further research to address the role of ANGPLT4 in tumor progression.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

Qian

Cao

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Although emerging studies have implicated that Aiopoietin-like 4 Protein (ANGPTL4) is related to the aggressiveness and metastasis of many tumors, the role of ANGPLT4 in giant cell tumor (GCT) of bone was rarely investigated. The mechanism of ANGPLT4 in tumor-induced osteoclastogenesis still remains unclear. In this study, we first demonstrated that ANGPTL4 was highly expressed in GCT compared to normal tissues, while we showed that TGF-β2 released by osteoclasts induced bone resorption could increase the expression of ANGPTL4 in GCTSCs. By using the luciferase reporter assay, we found that two downstreams of TGF-β2, Smad3 and Smad4, could directly activate the promoter of ANGPTL4, which might explain the mechanism of TGF-β2-induced ANGPLT4 expression. Moreover, knockout of ANGPTL4 by TALENs in GCTSCs inhibited tumor growth, angiogenesis and osteoclastogenesis in GCT in vitro. By using the chick chorio-allantoic membrane (CAM) models, we further showed that inhibition of ANGPTL4 suppressed tumor growth and giant cell formation in vivo. In addition, some new pathways involved in ANGPTL4 application were identified through microarray assay, which may partly explain the mechanism of ANGPTL4 in GCT. Taken together, our study for the first time identified the role of ANGPLT4 in GCT of bone, which may provide a new target for the diagnosis and treatment of GCT.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

Qian

Cao

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…16 ANGPTL4 promotes oral squamous cell carcinoma metastasis by stimulating cell invasion. 17 ANGPTL4 induced by TGFβ via the Smad signalling pathway promotes breast cancer metastasis. 18 Recent reports indicate that the effect of ANGPTL4 on tumour metastasis may be mediated by integrin activation.…”

Section: Introductionmentioning

confidence: 99%

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

et al. 2016

View full text Add to dashboard Cite

Epidermal growth factor (EGF) is important for cancer cell proliferation, angiogenesis and metastasis in many types of cancer. However, the mechanisms involved in EGF-induced head and neck squamous cell carcinoma (HNSCC) metastasis remain largely unknown. In this study, we reveal that angiopoietin-like 4 (ANGPTL4) plays an important role in the regulation of EGF-induced cancer metastasis. We showed that EGF-induced ANGPTL4 expression promoted anoikis resistance and cancer cell migration and invasion in HNSCC. In addition, depletion of ANGPTL4 inhibited EGF-induced cancer cell invasion. Autocrine production of EGF-induced ANGPTL4 regulated the expression of matrix metalloproteinases (MMPs). The induction of MMP-1 gene expression by ANGPTL4-activated integrin β1 signalling occurred through the AP-1 binding site in the MMP-1 gene promoter. Furthermore, down-regulation of MMP-1 impeded EGF- and recombinant ANGPTL4-enhanced HNSCC cell migration and invasion. Depletion of ANGPTL4 significantly blocked EGF-primed extravasation and metastatic seeding of tumour cells and MMP-1 expression in lungs. However, no effect of ANGPTL4 on tumour growth was observed. These results suggest that EGF-induced expression and autocrine production of ANGPTL4 enhances HNSCC metastasis via the up-regulation of MMP-1 expression. Inhibition of ANGPTL4 expression may be a potential strategy for the treatment of EGFR-mediated HNSCC metastasis.

show abstract

“…The 5-year survival rate is 90% for patients without metastasis, but <40% for patients with metastasis, suggesting that the regional lymph node metastasis (RLNM) is one of the most adverse prognostic factors (4)(5)(6)(7)(8)(9)(10). However, the mechanisms of metastasis are poorly understood (11). Therefore, molecular changes in a number of oncogenes and tumor suppressor genes associated with development of OSCC may be important clues for preventing this disease, and elucidating the molecular mechanisms involved in cancer metastasis is needed (3,4).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer

Suzuki

Kasamatsu

Miyamoto

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

Abstract. Tropomodulin1 (TMOD1), which regulates the length and depolymerization of actin filaments by binding to the pointed end of the actin filament, has been reported to be a powerful diagnostic marker for ALK-negative anaplastic large-cell lymphoma; however, little is known about the relevance of TMOD1 in the behavior of oral squamous cell carcinoma (OSCC). We evaluated TMOD1 expression in OSCC-derived cell lines and primary OSCC samples (n=200) using quantitative reverse transcriptase-polymerase chain reaction, immunoblotting and semi-quantitative immunohistochemistry. We also analyzed the clinical correlation between TMOD1 expression status and clinical parameters in patients with OSCC and performed a prospective study using 40 primary OSCC samples. TMOD1 expression was upregulated significantly (p<0.05) in OSCC in vitro and in vivo compared with normal counterparts. TMOD1 expression also was correlated significantly (p= 0.0199 and p=0.0064, respectively) with regional lymph node metastasis (RLNM) and 5-year survival rates. This prospective study also showed that high TMOD1 expression was seen in 12 (75%) of 16 cases in RLNM-positive patients and 9 (37.5%) of 24 cases in RLNM-negative patients. The current data provide the first evidence that TMOD1 expression is a critical biomarker for RLNM and prognosis of patients with OSCC.

show abstract

ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma

Cited by 29 publications

References 42 publications

TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone

Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumour metastasis in head and neck squamous cell carcinoma

Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer

Contact Info

Product

Resources

About