<scp>B</scp>lockade of <scp>TRPA</scp>1 with <scp>HC</scp>‐030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system

Pereira, L.M.S.; Lima-Júnior, Roberto César Pereira; Bem, A.X.C.; Teixeira, Cristina; Grassi, Luigi; Medeiros, Raul Pinheiro; Marques-Neto, Raphael D.; Callado, Rodrigo Barbosa; Aragão, Karoline S.; Wong, Deysi Viviana Tenazoa; Vale, Mariana Lima; Brito, Gerly Anne Castro; Ribeiro, Ronaldo A.

doi:10.1002/j.1532-2149.2012.00177.x

Cited by 33 publications

(29 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The acetic acid-induced writhing test is a well-established nociceptive test that is mediated by the activation of nonselective cation channels expressed at peripheral nociceptive fibers, including transient receptor potential vanilloid 1, TRPA1, and glutamate receptors [24][25][26]. In this test, administrated AE by the i.g.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

View full text Add to dashboard Cite

Background: Interest in pecan (Carya illinoensis) nut shells, a by-product of the nut industry, has increased due to its anti-inflammatory and antioxidant activities. The goal of this study was to evaluate the antinociceptive and antiedematogenic activity and the mechanisms of the pecan shell aqueous extract (AE). Methods: First, we performed fingerprinting of C. illinoensis AE. The antinociceptive and antiedematogenic effects of AE intragastric (i.g.) administration in mice (male Swiss mice 20-30 g) were evaluated using the acetic acid test or after subcutaneous (s.c.) paw injection of diverse transient receptor potential ankyrin 1 (TRPA1) agonists, including hydrogen peroxide (H2O2), allyl isothiocyanate, or cinnamaldehyde. We also observed AE antinociceptive and antiedematogenic effects after carrageenan s.c. paw injection and measured H2O2 production. Moreover, we observed the development of adverse effects after AE i.g. treatment. Results: The high-performance liquid chromatography fingerprinting of AE showed the presence of rutin. AE or rutin i.g. treatment produced antinociception in the acetic acid test and reduced the nociception and edema mediated by H2O2 s.c. hind paw injection or nociception induced by other TRPA1 agonists. Moreover, AE or rutin reduced the hyperalgesia, edema, and H2O2 production induced by carrageenan s.c. paw injection. No motor, gastric, or toxicological alterations were observed after AE administration. Conclusions: Collectively, the present results show that AE and its constituent rutin produced antinociceptive and antiedematogenic action in models of acute and persistent inflammatory nociception and it seems to be related to the inhibition of TRPA1 receptor activation.

show abstract

Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Their effect is mediated through different intracellular pathways, which culminate in the phosphorylation of the channel through PKC or PKA [70]. Furthermore, prostaglandins like PGA 1 , PGA 2 , 8-iso-PGA 2 , 15-deoxy-PGJ 2 and D12-PGJ 2 , formed by non-enzymatic dehydration of the respective PGs (PGD 2 , PGE 2 and PGE 1 ), are also TRPA1 ligands and directly gate the channel to cause acute nociception [50,71,72]. Based on the recent evidence that TRPA1 antagonists alleviate visceral nociception, the blockade of cyclopentone prostaglandin formation may represent a novel avenue for therapeutic intervention in inflammatory visceral pain [72].…”

Section: Lipid Metabolites As Modulators Of Trp Channel Functionmentioning

confidence: 99%

“…Furthermore, prostaglandins like PGA 1 , PGA 2 , 8-iso-PGA 2 , 15-deoxy-PGJ 2 and D12-PGJ 2 , formed by non-enzymatic dehydration of the respective PGs (PGD 2 , PGE 2 and PGE 1 ), are also TRPA1 ligands and directly gate the channel to cause acute nociception [50,71,72]. Based on the recent evidence that TRPA1 antagonists alleviate visceral nociception, the blockade of cyclopentone prostaglandin formation may represent a novel avenue for therapeutic intervention in inflammatory visceral pain [72]. Other prostaglandins like PGE2 activate GPCRs leading to TRPV4 channel phosphorylation and activation [73].…”

Section: Lipid Metabolites As Modulators Of Trp Channel Functionmentioning

confidence: 99%

TRP channels interaction with lipids and its implications in disease

Taberner

Fernández‐Ballester

Fernández-Carvajal

et al. 2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

View full text Add to dashboard Cite

Transient receptor potential (TRP) proteins are a family of ion channels central for sensory signaling. These receptors and, in particular, those involved in thermal sensing are also involved in pain signaling. Noteworthy, thermosensory receptors are polymodal ion channels that respond to both physical and chemical stimuli, thus integrating different environmental clues. In addition, their activity is modulated by algesic agents and lipidergic substances that are primarily released in pathological states. Lipids and lipid-like molecules have been found that can directly activate some thermosensory channels or modulate their activity by either potentiating or inhibiting it. To date, more than 50 endogenous lipids that can regulate TRP channel activity in sensory neurons have been described, thus representing the majority of known endogenous TRP channel modulators. Lipid modulators of TRP channels comprise lipids from a variety of metabolic pathways, including metabolites of the cyclooxygenase, lipoxygenase and cytochrome-P450 pathways, phospholipids and lysophospholipids. Therefore, TRP-channels are able to integrate and interpret incoming signals from the different metabolic lipid pathways. Taken together, the large number of lipids that can activate, sensitize or inhibit neuronal TRP-channels highlights the pivotal role of these molecules in sensory biology as well as in pain transduction and perception. This article is part of a Special Issue entitled: Lipid-protein interactions. Guest Editors: Amitabha Chattopadhyay and Jean-Marie Ruysschaert.

show abstract

“…Of note, in the bladder, the TRPA1 antagonist HC-030031 [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide; Fig. 10] failed to inhibit the pain reaction induced by ifosfamide (an NO donor) (Pereira et al, 2013). …”

Section: Transient Receptor Potential Channels: Acquired Diseasesmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

View full text Add to dashboard Cite

Blockade of TRPA1 with HC‐030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system

Abstract: Our findings suggest that the blockade of TRPA1 attenuates visceral nociception by a mechanism independent of the modulation of resident cells, nitric oxide and opioid pathways.

Cited by 33 publications

References 42 publications

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

TRP channels interaction with lipids and its implications in disease

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Contact Info

Product

Resources

About