<scp>B</scp>onferroni Inequalities and Intervals

Costigan, Timothy M.

doi:10.1002/0470011815.b2a15014

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…The multiple significance level across the four primary tests was set to 5% (two-sided). In order to adjust for multiple testing, the Bonferroni method [22] was applied. The primary results provide confirmatory statistical evidence.…”

Section: Methodsmentioning

confidence: 99%

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study

Bolke¹,

Schlippe²,

Gerß³

et al. 2019

Nutrients

128

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The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN ® (QUIRIS Healthcare, Gütersloh, Germany) on skin aging and skin health. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. They received either the food supplement (n = 36) or a placebo (n = 36) for twelve weeks. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. The test product significantly improved skin hydration, elasticity, roughness, and density. The differences between the verum group and the placebo group were statistically significant for all test parameters. These positive effects were substantially retained during the follow-up. The measured effects were fully consistent with the subjective assessments of the study participants. The nutraceutical was well tolerated.

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Section: Methodsmentioning

confidence: 99%

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study

Bolke¹,

Schlippe²,

Gerß³

et al. 2019

Nutrients

128

View full text Add to dashboard Cite

show abstract

“…Post hoc tests for pairwise comparisons were performed when global tests reached significance at the 5% level ( p Ͻ 0.05). The Bonferroni's correction (Costigan, 1998) was applied to pairwise tests: a difference was considered significant when the p value was Ͻ0.0167 (0.05/3). Statistical analyses were performed using the Stata software package (version 8.0; Stata, College Station, TX) by the Center for Biostatistics at the University of Connecticut Health Center.…”

Section: Methodsmentioning

confidence: 99%

Anti-GM1 Antibodies Cause Complement-Mediated Disruption of Sodium Channel Clusters in Peripheral Motor Nerve Fibers

Susuki¹,

Rasband²,

Tohyama³

et al. 2007

J. Neurosci.

341

276

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Voltage-gated Naϩ (Na v ) channels are highly concentrated at nodes of Ranvier in myelinated axons and facilitate rapid action potential conduction. Autoantibodies to gangliosides such as GM1 have been proposed to disrupt nodal Nav channels and lead to Guillain-Barré syndrome, an autoimmune neuropathy characterized by acute limb weakness. To test this hypothesis, we examined the molecular organization of nodes in a disease model caused by immunization with gangliosides. At the acute phase with progressing limb weakness, Na v channel clusters were disrupted or disappeared at abnormally lengthened nodes concomitant with deposition of IgG and complement products. Paranodal axoglial junctions, the nodal cytoskeleton, and Schwann cell microvilli, all of which stabilize Na v channel clusters, were also disrupted. The nodal molecules disappeared in lesions with complement deposition but no localization of macrophages. During recovery, complement deposition at nodes decreased, and Na v channels redistributed on both sides of affected nodes. These results suggest that Na v channel alterations occur as a consequence of complement-mediated disruption of interactions between axons and Schwann cells. Our findings support the idea that acute motor axonal neuropathy is a disease that specifically disrupts the nodes of Ranvier.

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Bonferroni Inequalities and Intervals

Cited by 2 publications

References 61 publications

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study

Anti-GM1 Antibodies Cause Complement-Mediated Disruption of Sodium Channel Clusters in Peripheral Motor Nerve Fibers

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